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Comprehensive Overview of TRIS-d11 (crystalline) (CAS No. 202656-13-1): Properties, Applications, and Industry Insights

TRIS-d11 (crystalline), identified by its CAS number 202656-13-1, is a deuterated derivative of tris(hydroxymethyl)aminomethane (TRIS), a widely used buffer in biochemical and pharmaceutical research. The incorporation of deuterium atoms (d11) enhances its utility in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), making it indispensable for isotope labeling studies and metabolic research. This article delves into its molecular characteristics, applications, and relevance in contemporary scientific advancements.

The crystalline form of TRIS-d11 ensures high purity and stability, critical for sensitive experiments. Its deuterated structure minimizes proton interference in NMR analysis, enabling clearer signal detection for protein structure determination and small-molecule interaction studies. Researchers increasingly favor deuterated compounds like TRIS-d11 to address challenges in dynamic nuclear polarization (DNP) and quantitative metabolomics.

In the pharmaceutical industry, TRIS-d11 (crystalline) plays a pivotal role in drug development and formulation stability testing. Its ability to maintain pH in deuterated solvents aligns with the growing demand for deuterated APIs (active pharmaceutical ingredients) and precision medicine. A 2023 study highlighted its use in optimizing liposome-based drug delivery systems, a trending topic in nanomedicine.

Environmental scientists also leverage CAS 202656-13-1 for isotope tracing in ecological studies. As sustainability gains traction, deuterated markers help track carbon cycling and pollutant degradation pathways. This aligns with Google Trends data showing rising searches for "deuterated compounds in green chemistry" and "stable isotope applications."

From a technical perspective, TRIS-d11 exhibits a molecular weight of 127.18 g/mol and a melting point of 168-172°C. Its solubility in D2O (deuterium oxide) and organic solvents like dimethyl sulfoxide-d6 (DMSO-d6) facilitates diverse experimental setups. Storage recommendations emphasize protection from moisture to preserve its crystalline integrity—a frequent query among first-time users.

The compound's safety profile is another hot topic. Unlike non-deuterated TRIS, TRIS-d11 requires specific handling to avoid isotopic exchange, a concern raised in forums like ResearchGate. Proper disposal methods for deuterated waste are also debated, reflecting broader interest in lab sustainability practices.

Emerging applications include neutron scattering techniques, where TRIS-d11's deuterium content improves contrast in soft matter research. This connects to trending searches for "deuterated biomaterials" and "advanced structural biology tools." Manufacturers now offer customized isotopic enrichment (e.g., 98% D) to meet niche demands.

In summary, TRIS-d11 (crystalline) (202656-13-1) bridges fundamental research and cutting-edge applications. Its versatility in NMR, drug formulation, and environmental science ensures continued relevance. As AI-driven molecular modeling accelerates, the demand for high-purity deuterated standards like TRIS-d11 will likely grow, solidifying its status as a cornerstone reagent in modern laboratories.

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