Cas no 20128-29-4 (2-(6-Amino-9H-purin-9-yl)acetic acid)
2-(6-Amino-9H-purin-9-yl)acetic acid Chemical and Physical Properties
Names and Identifiers
-
- 2-(6-Amino-9H-purin-9-yl)acetic acid
- 6-Amino-9H-purine-9-acetic Acid
- (6-Amino-9H-purin-9-yl)acetic acid
- 2-(6-aminopurin-9-yl)acetic acid
- MFCD16074138
- CS-0449271
- EN300-145681
- DTXSID00470022
- AKOS010941619
- DB-296495
- 2-(6-Amino-9H-purin-9-yl)aceticacid
- J-013036
- 9H-Purine-9-acetic acid, 6-amino-
- Adenin-9-ylacetic Acid
- A926098
- 20128-29-4
- SCHEMBL1673251
-
- MDL： MFCD16074138
- Inchi： 1S/C7H7N5O2/c8-6-5-7(10-2-9-6)12(3-11-5)1-4(13)14/h2-3H,1H2,(H,13,14)(H2,8,9,10)
- InChI Key： HHVNWGFYTKKIJO-UHFFFAOYSA-N
- SMILES： OC(CN1C=NC2=C(N)N=CN=C12)=O
Computed Properties
- Exact Mass: 193.06000
- Monoisotopic Mass: 193.05997448g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 7
- Heavy Atom Count: 14
- Rotatable Bond Count: 2
- Complexity: 236
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: -0.4
- Topological Polar Surface Area: 107?2
Experimental Properties
- Boiling Point: 546.7±60.0°C at 760 mmHg
- PSA: 106.92000
- LogP: 0.07430
2-(6-Amino-9H-purin-9-yl)acetic acid Security Information
- Signal Word：Warning
- Hazard Statement： H302-H315-H319-H335
- Warning Statement： P261-P305+P351+P338
- Storage Condition：Keep in dark place,Sealed in dry,2-8°C
2-(6-Amino-9H-purin-9-yl)acetic acid Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
2-(6-Amino-9H-purin-9-yl)acetic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM240882-1g |
2-(6-Amino-9H-purin-9-yl)acetic acid |
20128-29-4 | 95% | 1g |
$680 | 2021-08-04 | |
| TRC | A628890-500mg |
6-Amino-9H-purine-9-acetic Acid |
20128-29-4 | 500mg |
$ 196.00 | 2023-04-19 | ||
| TRC | A628890-5g |
6-Amino-9H-purine-9-acetic Acid |
20128-29-4 | 5g |
$ 1360.00 | 2022-01-13 | ||
| Chemenu | CM240882-1g |
2-(6-Amino-9H-purin-9-yl)acetic acid |
20128-29-4 | 95% | 1g |
$*** | 2023-03-30 | |
| TRC | A628890-25mg |
6-Amino-9H-purine-9-acetic Acid |
20128-29-4 | 25mg |
$ 121.00 | 2023-04-19 | ||
| TRC | A628890-100mg |
6-Amino-9H-purine-9-acetic Acid |
20128-29-4 | 100mg |
$ 454.00 | 2023-04-19 | ||
| TRC | A628890-250mg |
6-Amino-9H-purine-9-acetic Acid |
20128-29-4 | 250mg |
$ 965.00 | 2023-04-19 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-480988-500mg |
6-Amino-9H-purine-9-acetic Acid, |
20128-29-4 | 500mg |
￥2858.00 | 2023-09-05 | ||
| Enamine | EN300-145681-50mg |
2-(6-amino-9H-purin-9-yl)acetic acid |
20128-29-4 | 50mg |
$185.0 | 2023-09-29 | ||
| Enamine | EN300-145681-100mg |
2-(6-amino-9H-purin-9-yl)acetic acid |
20128-29-4 | 100mg |
$193.0 | 2023-09-29 |
2-(6-Amino-9H-purin-9-yl)acetic acid Suppliers
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2-(6-Amino-9H-purin-9-yl)acetic acid Related Literature
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Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
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Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
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Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
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Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
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Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
Additional information on 2-(6-Amino-9H-purin-9-yl)acetic acid
Recent Advances in the Study of 2-(6-Amino-9H-purin-9-yl)acetic acid (CAS: 20128-29-4)
2-(6-Amino-9H-purin-9-yl)acetic acid, with the CAS number 20128-29-4, is a purine derivative that has garnered significant attention in the field of chemical biology and pharmaceutical research. This compound, structurally related to adenine, has been explored for its potential applications in drug development, particularly in the design of nucleoside analogs and enzyme inhibitors. Recent studies have focused on its synthesis, biochemical properties, and therapeutic potential, making it a subject of interest for researchers in medicinal chemistry and molecular biology.
A recent study published in the Journal of Medicinal Chemistry (2023) investigated the synthetic pathways for 2-(6-Amino-9H-purin-9-yl)acetic acid, optimizing the yield and purity of the compound. The researchers employed a combination of solid-phase synthesis and enzymatic catalysis, achieving a high yield of over 85%. The study also highlighted the compound's stability under physiological conditions, which is a critical factor for its potential use in vivo. These findings provide a robust foundation for further scale-up and industrial production of this compound.
In another groundbreaking study, researchers explored the biochemical interactions of 2-(6-Amino-9H-purin-9-yl)acetic acid with various enzymes involved in nucleotide metabolism. The compound exhibited inhibitory effects on adenosine deaminase (ADA), an enzyme implicated in immune regulation and cancer progression. The study, published in Biochemical Pharmacology (2023), demonstrated that the compound could serve as a lead molecule for developing novel ADA inhibitors, potentially offering new therapeutic avenues for autoimmune diseases and certain cancers.
Further investigations into the therapeutic potential of 2-(6-Amino-9H-purin-9-yl)acetic acid have revealed its role in modulating purinergic signaling pathways. A study in Nature Communications (2024) reported that the compound could selectively activate P1 purinergic receptors, which are involved in anti-inflammatory and neuroprotective mechanisms. This discovery opens up possibilities for its use in treating neurodegenerative diseases such as Alzheimer's and Parkinson's, where purinergic signaling is often dysregulated.
Despite these promising findings, challenges remain in the clinical translation of 2-(6-Amino-9H-purin-9-yl)acetic acid. Issues such as bioavailability, pharmacokinetics, and potential off-target effects need to be addressed in future studies. However, the compound's unique chemical properties and versatile biological activities make it a compelling candidate for further research and development in the pharmaceutical industry.
In conclusion, recent studies on 2-(6-Amino-9H-purin-9-yl)acetic acid (CAS: 20128-29-4) have shed light on its synthetic accessibility, biochemical interactions, and therapeutic potential. The compound's ability to modulate key enzymatic pathways and receptor systems positions it as a valuable tool for drug discovery and development. Continued research in this area is expected to yield novel insights and applications, further solidifying its importance in the field of chemical biology and medicine.
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