• 1. Concentration and basicity of histamine rotamers
  Márta Kraszni,József K?k?si,Béla Noszál J. Chem. Soc. Perkin Trans. 2 2002 914
• 2. An efficient olefination method catalysed by dibutyl telluride
  Yao-Zeng Huang,Li-Lan Shi,Sao-Wei Li,Xue-Qing Wen J. Chem. Soc. Perkin Trans. 1 1989 2397
• 3. Baker's yeast-mediated transformations of α-keto epoxides
  Otto Meth-Cohn,R. Martinus Horak,Gerda Fouché J. Chem. Soc. Perkin Trans. 1 1994 1517

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

1-Bromo-3-Methylbutan-2-One (CAS No. 19967-55-6): A Comprehensive Overview

1-Bromo-3-methylbutan-2-one, also known by its CAS number 19967-55-6, is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, pharmaceuticals, and materials science. This compound, with the molecular formula C?H?BrO, is a brominated ketone that exhibits unique chemical properties, making it a valuable intermediate in various industrial and research applications. Recent advancements in synthetic chemistry have further highlighted its potential in the development of novel compounds with tailored functionalities.

The structure of 1-bromo-3-methylbutan-2-one consists of a four-carbon chain with a ketone group at the second position and a bromine atom at the first position. The methyl group attached to the third carbon introduces steric hindrance, which can influence the reactivity of the compound in different chemical transformations. This structural feature has been exploited in numerous studies to design selective reactions, such as nucleophilic substitutions and enolate formations, which are pivotal in organic synthesis.

Recent research has focused on the use of 1-bromo-3-methylbutan-2-one as a key intermediate in the synthesis of bioactive molecules. For instance, studies have demonstrated its utility in the construction of complex natural product analogs, where its bromine atom serves as an excellent leaving group for substitution reactions. Moreover, its ketone functionality allows for further derivatization, enabling the creation of diverse chemical libraries for drug discovery.

In the context of materials science, 1-bromo-3-methylbutan-2-one has been employed as a precursor for the synthesis of advanced polymers and coatings. Its ability to undergo controlled polymerization reactions has led to the development of materials with enhanced mechanical and thermal properties. Recent breakthroughs in this area have been documented in high-profile journals, underscoring its importance as a building block for functional materials.

The synthesis of 1-bromo-3-methylbutan-2-one has also been optimized through green chemistry approaches. Traditional methods often involved multi-step procedures with hazardous reagents; however, modern techniques now favor more efficient and environmentally friendly protocols. For example, recent studies have reported the use of microwave-assisted synthesis to achieve higher yields and shorter reaction times, aligning with current trends toward sustainable chemical practices.

From an analytical perspective, 1-bromo-3-methylbutan-2-one has been extensively studied using advanced spectroscopic techniques such as NMR and IR spectroscopy. These studies have provided deeper insights into its molecular conformation and reactivity under various conditions. Additionally, computational chemistry methods have been employed to predict its electronic properties and reaction pathways, further enhancing our understanding of this compound.

In conclusion, 1-bromo-3-methylbutan-2-one (CAS No. 19967-55-6) stands out as a critical compound in contemporary chemical research. Its unique structure and reactivity make it an indispensable tool in organic synthesis, drug discovery, and materials science. As research continues to uncover new applications and optimized synthetic routes for this compound, its role in advancing chemical innovation is set to grow even further.

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