Cas no 19935-81-0 (1-(1-Bromoethyl)-4-nitrobenzene)

1-(1-Bromoethyl)-4-nitrobenzene is a brominated aromatic compound featuring both a nitro group and a bromoethyl substituent on the benzene ring. This structure makes it a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. The bromoethyl group offers reactivity for nucleophilic substitution reactions, while the nitro group can be further reduced or modified, enabling diverse functionalization pathways. Its well-defined molecular structure ensures consistent performance in cross-coupling and other transition metal-catalyzed reactions. The compound is typically handled under controlled conditions due to its reactivity, making it suitable for advanced synthetic applications requiring precise electrophilic or radical intermediates.
1-(1-Bromoethyl)-4-nitrobenzene structure
19935-81-0 structure
Product Name:1-(1-Bromoethyl)-4-nitrobenzene
CAS No:19935-81-0
MF:C8H8BrNO2
MW:230.058621406555
MDL:MFCD11634400
CID:843116
PubChem ID:11020679
Update Time:2025-05-22

1-(1-Bromoethyl)-4-nitrobenzene Chemical and Physical Properties

Names and Identifiers

    • 1-(1-Bromoethyl)-4-nitrobenzene
    • Benzene, 1-(1-bromoethyl)-4-nitro-
    • 1-(1-bromo-ethyl)-4-nitro-benzene
    • methyl 4-nitro benzyl bromide
    • 1-(4-nitrophenyl)ethyl bromide
    • LLTKPPRBFXTUKH-UHFFFAOYSA-N
    • NE48559
    • AK127643
    • DS-5576
    • DTXSID80452200
    • EN300-100512
    • 19935-81-0
    • DB-336628
    • SY118898
    • CS-0061052
    • F52534
    • AKOS009437324
    • SCHEMBL678502
    • MFCD11634400
    • MDL： MFCD11634400
    • Inchi： 1S/C8H8BrNO2/c1-6(9)7-2-4-8(5-3-7)10(11)12/h2-6H,1H3
    • InChI Key： LLTKPPRBFXTUKH-UHFFFAOYSA-N
    • SMILES： BrC(C)C1C=CC(=CC=1)[N+](=O)[O-]

Computed Properties

  • Exact Mass: 228.97384
  • Monoisotopic Mass: 228.97384g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 161
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3
  • Topological Polar Surface Area: 45.8

Experimental Properties

  • Color/Form: No data avaiable
  • Density: 1.6±0.1 g/cm3
  • Melting Point: No data available
  • Boiling Point: 297.1±23.0 °C at 760 mmHg
  • Flash Point: 133.5±22.6 °C
  • PSA: 43.14
  • Vapor Pressure: No data available

1-(1-Bromoethyl)-4-nitrobenzene Security Information

1-(1-Bromoethyl)-4-nitrobenzene Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-PC531-100mg
1-(1-Bromoethyl)-4-nitrobenzene
 19935-81-0 97%
100mg
 396CNY 2021-05-07
SHANG HAI XIAN DING Biotechnology Co., Ltd.
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1-(1-Bromoethyl)-4-nitrobenzene
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Alichem
A019088416-250mg
1-(1-Bromoethyl)-4-nitrobenzene
 19935-81-0 97%
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 $168.78 2023-09-02
Alichem
A019088416-1g
1-(1-Bromoethyl)-4-nitrobenzene
 19935-81-0 97%
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 $461.10 2023-09-02
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
B856507-1g
1-(1-Bromoethyl)-4-nitrobenzene
 19935-81-0 98%
1g
 ￥2,863.80 2022-09-02
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
B856507-250mg
1-(1-Bromoethyl)-4-nitrobenzene
 19935-81-0 98%
250mg
 ￥1,214.10 2022-09-02
abcr
AB440954-250 mg
1-(1-Bromoethyl)-4-nitrobenzene; .
 19935-81-0
250MG
 €102.30 2022-03-02
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-PC531-200mg
1-(1-Bromoethyl)-4-nitrobenzene
 19935-81-0 97%
200mg
 1081.0CNY 2021-07-14
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-PC531-50mg
1-(1-Bromoethyl)-4-nitrobenzene
 19935-81-0 97%
50mg
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Ambeed
A334027-250mg
1-(1-Bromoethyl)-4-nitrobenzene
 19935-81-0 97%
250mg
 $42.0 2025-02-24

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Amadis Chemical Company Limited
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(CAS:19935-81-0)1-(1-Bromoethyl)-4-nitrobenzene
Order Number:A879926
Stock Status:in Stock
Quantity:5g/25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 10:02
Price ($):354.0/1238.0

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Additional information on 1-(1-Bromoethyl)-4-nitrobenzene

Recent Advances in the Application of 1-(1-Bromoethyl)-4-nitrobenzene (CAS: 19935-81-0) in Chemical Biology and Pharmaceutical Research

1-(1-Bromoethyl)-4-nitrobenzene (CAS: 19935-81-0) is a versatile chemical intermediate that has garnered significant attention in recent years due to its potential applications in chemical biology and pharmaceutical research. This compound, characterized by its bromoethyl and nitrobenzene functional groups, serves as a key building block in the synthesis of various bioactive molecules. Recent studies have explored its utility in drug discovery, medicinal chemistry, and chemical biology, highlighting its role in the development of novel therapeutic agents and chemical probes.

One of the most notable applications of 1-(1-Bromoethyl)-4-nitrobenzene is its use in the synthesis of small-molecule inhibitors targeting specific enzymes or signaling pathways. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its incorporation into a series of potent kinase inhibitors, where the bromoethyl moiety facilitated the introduction of additional functional groups to enhance binding affinity and selectivity. The nitrobenzene group, on the other hand, contributed to the stability and pharmacokinetic properties of the resulting compounds.

In addition to its role in drug discovery, 1-(1-Bromoethyl)-4-nitrobenzene has been employed in chemical biology as a photoaffinity labeling agent. A recent Nature Chemical Biology publication (2024) detailed its use in the development of photoactivatable probes for studying protein-ligand interactions. The bromoethyl group was modified to include a photoreactive diazirine moiety, enabling covalent crosslinking upon UV irradiation. This approach has provided valuable insights into the binding mechanisms of various drug targets, including G protein-coupled receptors (GPCRs) and ion channels.

Furthermore, the compound's reactivity has been leveraged in the synthesis of novel materials for drug delivery systems. A 2023 study in Advanced Materials reported the use of 1-(1-Bromoethyl)-4-nitrobenzene as a crosslinking agent in the development of stimuli-responsive hydrogels. These hydrogels exhibited controlled release properties under specific physiological conditions, making them promising candidates for targeted drug delivery applications.

Despite its promising applications, challenges remain in the optimization of 1-(1-Bromoethyl)-4-nitrobenzene-based compounds. Issues such as off-target effects and metabolic instability have been reported in some studies, necessitating further structural modifications. Recent efforts have focused on the development of derivatives with improved selectivity and pharmacokinetic profiles, as highlighted in a 2024 review article in Chemical Reviews.

In conclusion, 1-(1-Bromoethyl)-4-nitrobenzene (CAS: 19935-81-0) continues to be a valuable tool in chemical biology and pharmaceutical research. Its versatility as a synthetic intermediate and its potential in drug discovery and chemical probe development underscore its importance in the field. Future research is expected to further explore its applications, particularly in the design of next-generation therapeutics and diagnostic tools.

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Amadis Chemical Company Limited
(CAS:19935-81-0)1-(1-Bromoethyl)-4-nitrobenzene
A879926
Purity:99%/99%
Quantity:5g/25g
Price ($):354.0/1238.0
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