Cas no 19916-73-5 (O6-Benzylguanine)

O6-Benzylguanine (O6-BG) is a potent and selective inhibitor of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT). It is widely utilized in research to sensitize tumor cells to alkylating chemotherapeutic agents, such as temozolomide, by blocking AGT-mediated repair of O6-alkylguanine lesions. This enhances the cytotoxicity of these agents, making O6-BG a valuable tool in studying resistance mechanisms and improving cancer treatment efficacy. Its high specificity and well-characterized mechanism of action make it a critical compound in experimental oncology and DNA damage response studies. O6-Benzylguanine is typically supplied as a stable, lyophilized powder for reconstitution in aqueous or organic solvents.

O6-Benzylguanine structure

Product Name:O6-Benzylguanine

CAS No:19916-73-5

MF:C₁₂H₁₁N₅O

MW:241.248641252518

MDL:MFCD00269931

CID:51428

PubChem ID:24278259

Update Time:2025-06-08

O6-Benzylguanine Chemical and Physical Properties

Names and Identifiers

- 6-(Benzyloxy)-7H-purin-2-amine
- 6-Benzyloxy Guanine
- 2-amino-6-benzyloxypurine
- O-6-Benzylguanine
- 6-o-Benzylguanine
- 6-phenylmethoxy-7H-purin-2-amine
- O6-Benzylguanine
- : 6-O-Benzylguanine
- 2-Amino-6-(benzyloxy)purine
- 2-amino-6-(phenylmethoxy)-9H-purine
- 2-Amino-6-benzyloxy-9H-purine
- 6-(benzyloxy)guanine
- 6-(phenylmethoxy)-9H-purin-2-amine
- amino-6-(phenylmethoxy)-9H-purine
- O(6)-Benzylguanine
- O(6)-Bgua
- NSC 637037
- 6-benzylguanine
- 6-oxo -benzylguanine
- 4 6-Benzyloxyguanine
- 6-O-Benzylguanine(O6BG)
- O(sup 6)benzylguanidine
- O6-Benzylguanine ,98%
- UNII-01KC87F8FE
- Lopac0_000181
- NCGC00260866-01
- MFCD00269931
- 1H-Purin-2-amine, 6-(phenylmethoxy)-
- FT-0650712
- o6-benzyl-guanine
- NS00069977
- GLXC-25126
- NCGC00015144-01
- CS-W002585
- AKOS015963409
- HMS3260F03
- BDBM5491
- NCGC00015144-03
- BCP08777
- SR-01000075709-1
- HY-W002585
- SY008080
- CCG-204276
- B 2292
- DB11919
- O6 -benzylguanine
- KRWMERLEINMZFT-UHFFFAOYSA-N
- MLS000859930
- O6-Substituted Guanine Deriv. 31
- NCGC00093660-01
- SB17232
- MLS006010145
- Lopac-B-2292
- 19916-73-5
- O6BG
- NSC637037
- 6-(Benzyloxy)-7H-purin-2-ylamine
- KS-5281
- 0.4 CH3OH
- O6-Benzylguanine- Bio-X
- NSC-637037
- SMR000326791
- NCGC00093660-02
- SCHEMBL61740
- 6-benzyloxy-2-amino-purine
- 6-benzyloxy-9H-purin-2-amine
- Q7072275
- AM20060538
- OBG
- s3658
- 9H-Purin-2-amine, 6-(phenylmethoxy)-
- KRX-0402
- CCRIS 9383
- 6-(Phenylmethoxy)-1H-purin-2-amine
- O6-BENZYLGUANINE [WHO-DD]
- Purine, 2-amino-6-(benzyloxy)- (, )
- EU-0100181
- AKOS015919415
- DTXSID20173700
- NCGC00015144-02
- SDCCGSBI-0050169.P002
- HMS3369A16
- SR-01000075709
- NCI60_012280
- 6-(benzyloxy)-9H-purin-2-amine
- BB164163
- O6-Benzylguanine, >=98% (TLC), solid
- NCGC00015144-04
- 01KC87F8FE
- 6-(benzyloxy)-1H-purin-2-amine
- LP00181
- Purine, 8CI)
- W-201741
- Purine, 2-amino-6-(benzyloxy)-
- 1000874-21-4
- O6-BG
- Tox21_500181
- MLS001074887
- AC-1076
- 6-benzyloxy-7H-purin-2-amine
- NCGC00015144-08
- 6-Benzyloxyguanine
- CHEMBL407874
- HMS2234P23
- BRD-K92041145-001-09-5
- O(6)-Benzylguanine?
- DA-56359
- MDL： MFCD00269931
- Inchi： 1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)
- InChI Key： KRWMERLEINMZFT-UHFFFAOYSA-N
- SMILES： O(CC1C=CC=CC=1)C1=C2C(=NC(N)=N1)N=CN2

Computed Properties

Exact Mass: 241.09600
Monoisotopic Mass: 241.096
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 6
Heavy Atom Count: 18
Rotatable Bond Count: 3
Complexity: 271
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: 9
XLogP3: nothing
Topological Polar Surface Area: 89.7A^2

Experimental Properties

Color/Form: White to Yellow Solid
Density: 1.4310
Melting Point: 205-210°C
Boiling Point: 621.4±63.0 °C at 760 mmHg
Flash Point: 329.6℃
Refractive Index: 1.743
Solubility: methanol: 20?mg/mL
PSA: 89.71000
LogP: 2.09530
Solubility: Soluble in methanol

O6-Benzylguanine Security Information

Symbol:
Signal Word：Warning
Hazard Statement： H315,H319,H335
Warning Statement： P261,P305+P351+P338
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Hazard Category Code： 36/37/38
Safety Instruction： S26-S36
Hazardous Material Identification：
Storage Condition：Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Safety Term：S26;S36
Risk Phrases：R36/37/38

O6-Benzylguanine Customs Data

HS CODE：2933990090
Customs Data：

China Customs Code:
2933990090

Overview:

2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

Declaration elements:

Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

Summary:

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

O6-Benzylguanine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
MedChemExpress	HY-W002585-10mM*1mLinDMSO	O6-Benzylguanine	19916-73-5	99.84%	10mM*1mLinDMSO	￥270	2023-07-26
MedChemExpress	HY-W002585-10mg	O6-Benzylguanine	19916-73-5	99.84%	10mg	￥240	2023-08-31
MedChemExpress	HY-W002585-25mg	O6-Benzylguanine	19916-73-5	99.84%	25mg	￥448	2024-07-20
MedChemExpress	HY-W002585-50mg	O6-Benzylguanine	19916-73-5	99.84%	50mg	￥720	2024-07-20
MedChemExpress	HY-W002585-100mg	O6-Benzylguanine	19916-73-5	99.84%	100mg	￥1159	2024-07-20
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	B101579-5g	O6-Benzylguanine	19916-73-5	98%	5g	￥53.90	2023-09-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	B101579-100g	O6-Benzylguanine	19916-73-5	98%	100g	￥387.90	2023-09-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	B101579-100mg	O6-Benzylguanine	19916-73-5	98%	100mg	￥29.90	2023-09-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	B101579-1g	O6-Benzylguanine	19916-73-5	98%	1g	￥31.90	2023-09-04
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	B101579-25g	O6-Benzylguanine	19916-73-5	98%	25g	￥121.90	2023-09-04

O6-Benzylguanine Suppliers

Suzhou Senfeida Chemical Co., Ltd

Gold Member

Audited Supplier

(CAS:19916-73-5)6-O-Benzylguanine

Order Number:sfd20749;1635863

Stock Status:in Stock

Quantity:200kg/Company Customization

Purity:99.9%/98%

Pricing Information Last Updated:Friday, 19 July 2024 14:38

Price ($):discuss personally

Email:[email protected]

Product Official Link

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:19916-73-5)O-6-芐基鳥(niǎo)嘌呤

Order Number:LE1635863

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:30

Price ($):discuss personally

Email:[email protected]

O6-Benzylguanine Related Literature

1. Nano-p–n junction heterostructure TiO2 nanobelts for the electrochemical detection of anticancer drug and biointeractions with cancer cells

Jingjie Cui,Yakun Ge,Shaowei Chen,Hongshi Zhao,Hong Liu,Zhen Huang,Huaidong Jiang,Jing Chen J. Mater. Chem. B 2013 1 2072
2. Nano-p–n junction heterostructure TiO2 nanobelts for the electrochemical detection of anticancer drug and biointeractions with cancer cells

Jingjie Cui,Yakun Ge,Shaowei Chen,Hongshi Zhao,Hong Liu,Zhen Huang,Huaidong Jiang,Jing Chen J. Mater. Chem. B 2013 1 2072
3. Nano-p–n junction heterostructure TiO2 nanobelts for the electrochemical detection of anticancer drug and biointeractions with cancer cells

Jingjie Cui,Yakun Ge,Shaowei Chen,Hongshi Zhao,Hong Liu,Zhen Huang,Huaidong Jiang,Jing Chen J. Mater. Chem. B 2013 1 2072
4. Nano-p–n junction heterostructure TiO2 nanobelts for the electrochemical detection of anticancer drug and biointeractions with cancer cells

Jingjie Cui,Yakun Ge,Shaowei Chen,Hongshi Zhao,Hong Liu,Zhen Huang,Huaidong Jiang,Jing Chen J. Mater. Chem. B 2013 1 2072
5. Correction: Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation

Zongren Zhao,Jiawei Shen,Long Zhang,Lansheng Wang,Haoyue Xu,Yuhan Han,Jun Jia,Yang Lu,Rutong Yu,Hongmei Liu Biomater. Sci. 2021 9 1466

Additional information on O6-Benzylguanine

O6-Benzylguanine: A Comprehensive Overview

O6-Benzylguanine, with the CAS number 19916-73-5, is a compound of significant interest in the fields of chemistry and biology. This compound has garnered attention due to its unique properties and potential applications in various scientific domains. In this article, we will delve into the structure, biological activity, and recent advancements related to O6-Benzylguanine.

The O6-Benzylguanine molecule is characterized by its guanine derivative structure, where a benzyl group is attached at the O6 position. This structural modification imparts distinct chemical and biological properties to the compound. Recent studies have highlighted its role as a DNA repair inhibitor, which makes it a valuable tool in cancer research and drug development.

One of the most notable aspects of O6-Benzylguanine is its ability to interact with specific proteins involved in DNA repair mechanisms. For instance, it has been shown to inhibit the activity of proteins such as O6-methylguanine-DNA methyltransferase (MGMT), which plays a critical role in repairing DNA damage. This property has led researchers to explore its potential as an adjunct therapy in combination with alkylating agents used in chemotherapy.

Recent advancements in O6-Benzylguanine research have focused on understanding its mechanism of action at a molecular level. Scientists have employed advanced techniques such as X-ray crystallography and computational modeling to elucidate how this compound binds to target proteins. These studies have provided valuable insights into the design of more effective inhibitors for therapeutic applications.

In addition to its role in cancer research, O6-Benzylguanine has also been investigated for its potential in other areas of medicine. For example, it has been studied as a tool for modulating immune responses and enhancing the efficacy of immunotherapies. These findings underscore the versatility of this compound and its potential impact on multiple therapeutic areas.

The synthesis and characterization of O6-Benzylguanine have also been subjects of extensive research. Chemists have developed novel synthetic routes to produce this compound with high purity and yield. These methods not only facilitate further experimental studies but also pave the way for large-scale production if it were to be commercialized as a drug candidate.

From an environmental perspective, understanding the degradation pathways and toxicity profile of O6-Benzylguanine is crucial for ensuring its safe use in research and potential clinical applications. Studies have been conducted to assess its biodegradability and environmental impact, providing essential information for regulatory compliance and risk assessment.

In conclusion, O6-Benzylguanine (CAS No: 19916-73-5) is a compound with promising applications in medicine and biology. Its role as a DNA repair inhibitor, combined with recent advancements in understanding its molecular mechanisms, positions it as a valuable tool in drug discovery and development. As research continues to unfold, this compound holds the potential to contribute significantly to advancements in cancer therapy and beyond.

19916-73-5 (O6-Benzylguanine) Related Products

Recommended suppliers