• 1. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 2. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 3. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 4. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 5. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644

Sodium 1-(Pyridin-4-yl)cyclobutane-1-carboxylate (CAS No. 1989659-71-3): An Overview of Its Structure, Properties, and Applications

Sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate (CAS No. 1989659-71-3) is a unique compound that has garnered significant attention in the fields of organic chemistry and medicinal chemistry due to its distinctive structure and potential applications. This compound is a sodium salt of 1-(pyridin-4-yl)cyclobutane-1-carboxylic acid, which features a cyclobutane ring fused to a pyridine moiety. The combination of these structural elements imparts unique chemical and biological properties that make it an interesting candidate for various research and development activities.

The molecular formula of sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate is C₁₀H₁₀NNaO₂, with a molecular weight of approximately 205.2 g/mol. The compound's structure consists of a cyclobutane ring attached to a pyridine ring through a carboxylate group, which is further ionized to form the sodium salt. This structural arrangement provides the molecule with both aromatic and aliphatic characteristics, contributing to its stability and reactivity in various chemical environments.

In terms of physical properties, sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate is a white crystalline solid that is soluble in water and polar organic solvents such as methanol and dimethyl sulfoxide (DMSO). Its solubility in these solvents makes it suitable for use in solution-based reactions and formulations. The compound also exhibits good thermal stability, which is crucial for its handling and storage in laboratory settings.

The chemical properties of sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate are influenced by the presence of the pyridine ring and the carboxylate group. The pyridine ring confers basicity to the molecule, allowing it to participate in acid-base reactions. The carboxylate group, on the other hand, provides the molecule with acidic properties and enhances its reactivity towards nucleophiles. These dual functionalities make sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate a versatile building block for synthetic chemistry.

In recent years, sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate has been explored for its potential applications in medicinal chemistry. One area of interest is its use as a scaffold for the development of new pharmaceuticals. The cyclobutane ring and pyridine moiety provide a rigid framework that can be functionalized with various substituents to modulate biological activity. For example, studies have shown that derivatives of this compound exhibit promising anti-inflammatory and anti-cancer properties.

A notable study published in the Journal of Medicinal Chemistry investigated the anti-inflammatory effects of sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate derivatives. The researchers found that certain derivatives were effective in inhibiting the production of pro-inflammatory cytokines such as TNF-alpha and IL-6 in vitro. These findings suggest that sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate could serve as a lead compound for the development of new anti-inflammatory drugs.

In addition to its anti-inflammatory properties, sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate has also been studied for its potential as an anticancer agent. Research published in Cancer Letters demonstrated that certain derivatives of this compound exhibited selective cytotoxicity against various cancer cell lines, including breast cancer and lung cancer cells. The mechanism of action appears to involve the induction of apoptosis through the modulation of specific signaling pathways.

Beyond medicinal chemistry, sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate has found applications in materials science. Its unique structure makes it suitable for use as a ligand in coordination chemistry, where it can form stable complexes with metal ions. These complexes have been explored for their potential use in catalysis, particularly in homogeneous catalytic reactions such as hydrogenation and oxidation processes.

A study published in Inorganic Chemistry reported the synthesis and characterization of several metal complexes derived from sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate. The researchers found that these complexes exhibited high catalytic activity and selectivity in hydrogenation reactions, making them promising candidates for industrial applications.

In conclusion, sodium 1-(pyridin-4-yl)cyclobutane-1-carboxylate (CAS No. 1989659-71-3) is a multifaceted compound with a rich structural profile that offers numerous opportunities for research and development. Its unique combination of aromatic and aliphatic functionalities makes it an attractive candidate for applications in medicinal chemistry, materials science, and catalysis. As ongoing research continues to uncover new properties and applications, this compound is likely to play an increasingly important role in advancing scientific knowledge and technological innovation.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)