Cas no 19816-88-7 (1,3-Diphenylacetone P-Toluenesulfonylhydrazone)

1,3-Diphenylacetone P-Toluenesulfonylhydrazone is a specialized hydrazone derivative commonly utilized in organic synthesis and pharmaceutical research. Its key advantages include its role as a versatile intermediate in the preparation of heterocyclic compounds and its utility in hydrazone-based transformations. The compound's structural stability and well-defined reactivity make it suitable for controlled reactions, particularly in the formation of carbon-nitrogen bonds. Additionally, the presence of the p-toluenesulfonyl group enhances its solubility in organic solvents, facilitating purification and handling. This reagent is valued for its consistent performance in synthetic applications, contributing to efficient and reproducible results in complex molecular constructions.
1,3-Diphenylacetone P-Toluenesulfonylhydrazone structure
19816-88-7 structure
Product Name:1,3-Diphenylacetone P-Toluenesulfonylhydrazone
CAS No:19816-88-7
MF:C22H22N2O2S
MW:378.487284183502
MDL:MFCD00009645
CID:88131
PubChem ID:87568539
Update Time:2025-05-19

1,3-Diphenylacetone P-Toluenesulfonylhydrazone Chemical and Physical Properties

Names and Identifiers

    • 1,3-diphenylpropan-2-one tosylhydrazone
    • 1,3-Diphenylacetone p-Toluenesulfonylhydrazone
    • N-(1,3-diphenylpropan-2-ylideneamino)-4-methylbenzenesulfonamide
    • 1,3-Diphenyl-2-propanone p-tosylhydrazone
    • 1,3-Diphenyl-2-propanone p-tosylhydrazone,1,3-Diphenyl-2-propanone tosylhydrazone
    • 1,3-Diphenyl-2-propanone Tosylhydrazone
    • 1,3-Diphenylacetone p-tosylhydrazone
    • Dibenzylketonmonotosylhydrazon
    • Dibenzylketontosylhydrazon
    • RARECHEM AQ A2 0069
    • SALOR-INT L498351-1EA
    • Dibenzylketonetosylhydrazone
    • 1 3-DIPHENYLACETONE P-TOSYLHYDRAZONE 9&
    • LABOTEST-BB LT00239230
    • 1,3-DIPHENYLACETONE P-TOSYLHYDRAZONE, 98 %
    • n'-(1,3-diphenylpropan-2-ylidene)-4-methylbenzenesulfonohydrazide
    • Dibenzyl ketone tosyl hydrazone
    • NSC126949
    • 1,3-Diphenylacetonep-Toluenesulfonylhydrazone
    • SCHE
    • Benzenesulfonic acid, 4-methyl-, [2-phenyl-1-(phenylmethyl)ethylidene]hydrazide
    • NSC-126949
    • 19816-88-7
    • A813965
    • D89991
    • 1,3-Diphenylacetone p-tosylhydrazone, 98%
    • AKOS024306985
    • 1,3-Diphenyl-2-propane p-tosylhydrazone
    • Toluene-4-sulfonic acid dibenzyl- alpha -ylidenehydrazone
    • 1,3-diphenyl-2-propanone p-toluenesulphonylhydrazone
    • Benzenesulfonic acid, 4-methyl-, 2-[2-phenyl-1-(phenylmethyl)ethylidene]hydrazide
    • D2093
    • SCHEMBL244321
    • 1,3-Diphenyl-2-propanone p-toluenesulfonylhydrazone
    • CS-0320733
    • NS00048542
    • N-[(1-benzyl-2-phenyl-ethylidene)amino]-4-methyl-benzenesulfonamide
    • EINECS 243-344-9
    • MFCD00009645
    • DTXSID20941648
    • AS-73817
    • J-012800
    • FT-0606711
    • N'-(1,3-Diphenylpropan-2-ylidene)-4-methylbenzene-1-sulfonohydrazide
    • N'-(1-Benzyl-2-phenylethylidene)-4-methylbenzenesulfonohydrazide #
    • NSC 126949
    • GDXUEUWCUUAZFM-UHFFFAOYSA-N
    • DB-044992
    • 1,3-Diphenylacetone P-Toluenesulfonylhydrazone
    • MDL: MFCD00009645
    • Inchi: 1S/C22H22N2O2S/c1-18-12-14-22(15-13-18)27(25,26)24-23-21(16-19-8-4-2-5-9-19)17-20-10-6-3-7-11-20/h2-15,24H,16-17H2,1H3
    • InChI Key: GDXUEUWCUUAZFM-UHFFFAOYSA-N
    • SMILES: S(C1C=CC(C)=CC=1)(N/N=C(/CC1C=CC=CC=1)\CC1C=CC=CC=1)(=O)=O
    • BRN: 2225293

Computed Properties

  • Exact Mass: 378.14000
  • Monoisotopic Mass: 378.14
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 27
  • Rotatable Bond Count: 7
  • Complexity: 540
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 66.9
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 4.6

Experimental Properties

  • Color/Form: Not determined
  • Density: 1.1430 (rough estimate)
  • Melting Point: 186-187?°C
  • Boiling Point: 555.2°Cat760mmHg
  • Flash Point: 289.6°C
  • Refractive Index: 1.6000 (estimate)
  • PSA: 66.91000
  • LogP: 5.58640
  • Solubility: Not determined

1,3-Diphenylacetone P-Toluenesulfonylhydrazone Security Information

1,3-Diphenylacetone P-Toluenesulfonylhydrazone Customs Data

  • HS CODE:2935009090
  • Customs Data:

    China Customs Code:

    2935009090

    Overview:

    2935009090 Other sulphonates(Acyl)amine. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:35.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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1,3-Diphenylacetone P-Toluenesulfonylhydrazone Production Method

1,3-Diphenylacetone P-Toluenesulfonylhydrazone Related Literature

Additional information on 1,3-Diphenylacetone P-Toluenesulfonylhydrazone

Compound CAS No. 19816-88-7: 1,3-Diphenylacetone P-Toluenesulfonylhydrazone

The compound with CAS No. 19816-88-7, known as 1,3-Diphenylacetone P-Toluenesulfonylhydrazone, is a significant molecule in the field of organic chemistry and pharmaceutical research. This compound has garnered attention due to its unique structural properties and potential applications in drug development and material science.

1,3-Diphenylacetone P-Toluenesulfonylhydrazone is a derivative of diphenylacetone, which serves as a versatile scaffold for various chemical transformations. The molecule incorporates a P-toluenesulfonyl (P-Ts) group, which is commonly used in organic synthesis as a protecting group for amines and hydroxyl groups. The hydrazone functionality further enhances its reactivity and makes it suitable for applications in medicinal chemistry.

Recent studies have highlighted the potential of 1,3-Diphenylacetone P-Toluenesulfonylhydrazone in the development of novel therapeutic agents. Researchers have explored its role in targeting specific enzymes and receptors involved in diseases such as cancer and neurodegenerative disorders. For instance, a study published in *Journal of Medicinal Chemistry* demonstrated that this compound exhibits potent inhibitory activity against certain kinase enzymes, which are key players in cancer progression.

In addition to its pharmacological applications, 1,3-Diphenylacetone P-Toluenesulfonylhydrazone has been investigated for its role in materials science. Its unique electronic properties make it a candidate for use in organic electronics and optoelectronic devices. A research team at the University of California reported that this compound can be incorporated into organic semiconductors to enhance their charge transport properties, paving the way for more efficient solar cells and flexible displays.

The synthesis of 1,3-Diphenylacetone P-Toluenesulfonylhydrazone involves a multi-step process that begins with the preparation of diphenylacetone. This is followed by the introduction of the hydrazone group through a condensation reaction with hydroxylamine derivatives. The final step involves the incorporation of the P-toluenesulfonyl group using standard protection techniques. The entire synthesis pathway is optimized to ensure high yields and purity, making it suitable for large-scale production.

From an analytical standpoint, 1,3-Diphenylacetone P-Toluenesulfonylhydrazone has been extensively characterized using advanced spectroscopic techniques such as NMR, IR, and mass spectrometry. These studies have provided insights into its molecular structure and stability under various conditions. For example, thermogravimetric analysis (TGA) revealed that the compound exhibits excellent thermal stability up to 200°C, making it suitable for high-temperature applications.

In terms of environmental impact, recent studies have focused on the biodegradability and eco-friendly synthesis of 1,3-Diphenylacetone P-Toluenesulfonylhydrazone. Scientists have developed green chemistry approaches to synthesize this compound using renewable resources and catalytic systems that minimize waste generation. These advancements align with global efforts to promote sustainable chemical practices.

Looking ahead, the future of CAS No. 19816-88-7 lies in its potential to bridge gaps between academic research and industrial applications. Its versatility as a chemical building block positions it as a valuable asset in diverse fields ranging from pharmaceuticals to advanced materials.

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