• 1. 107. Quinazolines. Part IV. Covalent hydration in the cations of substituted quinazolines
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Comprehensive Overview of 4,6,8-Trichloroquinazoline (CAS No. 19815-21-5): Properties, Applications, and Industry Insights

4,6,8-Trichloroquinazoline (CAS No. 19815-21-5) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. With its unique trichlorinated quinazoline structure, this compound serves as a versatile intermediate for synthesizing biologically active molecules. Researchers and industry professionals frequently search for terms like "4,6,8-Trichloroquinazoline synthesis", "CAS 19815-21-5 applications", and "quinazoline derivatives in drug discovery", reflecting its relevance in modern chemistry.

The molecular formula of 4,6,8-Trichloroquinazoline (C₈H₃Cl₃N₂) highlights its electron-deficient aromatic system, making it highly reactive in nucleophilic substitution reactions. This property aligns with current trends in green chemistry, where efficient halogenated intermediates reduce waste in multi-step syntheses. Recent publications emphasize its role in constructing EGFR kinase inhibitors and antifungal agents, addressing the growing demand for precision therapeutics.

From a commercial perspective, CAS 19815-21-5 is often discussed alongside high-value pharmaceutical intermediates and custom synthesis solutions. Analytical data shows rising searches for "quinazoline scaffold optimization" and "chlorinated heterocycles safety profiles", indicating balanced interest between innovation and regulatory compliance. The compound's crystalline form (typically white to off-white powder) and moderate solubility in organic solvents make it suitable for controlled reactions under GMP conditions.

Emerging applications of 4,6,8-Trichloroquinazoline include its use in photoactive materials and catalysis research, particularly in cross-coupling reactions. This connects to broader scientific discussions about sustainable synthetic methods and atom-economical processes. Laboratories handling this compound should note its stability under inert atmospheres and compatibility with common protecting group strategies, as frequently queried in "quinazoline handling protocols".

Quality specifications for CAS 19815-21-5 typically require ≥98% purity (HPLC), with strict control of residual solvents. Industry forums reveal increasing inquiries about "scale-up challenges for halogenated quinazolines" and "regioselective functionalization techniques", pointing to its expanding manufacturing footprint. The compound's melting point (210–215°C) and spectral characteristics (distinctive ¹H-NMR patterns) are critical for quality verification.

Environmental considerations regarding chlorinated compounds have led to improved synthetic routes for 4,6,8-Trichloroquinazoline, with recent patents describing catalytic chlorination methods that minimize byproducts. These advancements respond to search trends like "eco-friendly heterocycle synthesis" and "reducing halogen waste in APIs". Proper storage recommendations (desiccated, 2–8°C) and handling precautions are essential knowledge for users, as indicated by safety-related search queries.

The future outlook for 4,6,8-Trichloroquinazoline remains promising, particularly in targeted drug delivery systems and material science innovations. Its structural features enable diverse modifications, making it a subject of ongoing research—evidenced by rising academic citations and patent filings. For sourcing this compound, verified suppliers provide comprehensive COA documentation and stability studies, addressing procurement-related search intents such as "reliable CAS 19815-21-5 suppliers".

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