• 1. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 3. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 4. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 5. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577

Introduction to 6-Ethoxy-2,3,4-trifluorobenzoic acid (CAS No. 1980050-06-3)

6-Ethoxy-2,3,4-trifluorobenzoic acid (CAS No. 1980050-06-3) is a multifunctional organic compound that has garnered significant attention in recent years due to its unique chemical structure and potential applications in various fields, including pharmaceuticals, materials science, and chemical synthesis. This compound is characterized by its ethoxy and trifluoromethyl substituents on the benzene ring, which confer it with distinct physical and chemical properties.

The molecular formula of 6-Ethoxy-2,3,4-trifluorobenzoic acid is C₉H₆F₃O₃, and its molecular weight is approximately 219.14 g/mol. The presence of the trifluoromethyl group imparts strong electron-withdrawing properties, making this compound highly reactive in various chemical reactions. Additionally, the ethoxy group enhances its solubility in polar solvents and contributes to its stability under different conditions.

In the realm of pharmaceutical research, 6-Ethoxy-2,3,4-trifluorobenzoic acid has shown promise as a potential lead compound for the development of new drugs. Recent studies have explored its use as an intermediate in the synthesis of novel anti-inflammatory agents and anticancer drugs. For instance, a study published in the Journal of Medicinal Chemistry highlighted the role of this compound in enhancing the bioavailability and efficacy of certain drug candidates.

The unique combination of functional groups in 6-Ethoxy-2,3,4-trifluorobenzoic acid also makes it an attractive candidate for use in materials science. Researchers have investigated its potential as a building block for the synthesis of advanced polymers and coatings with enhanced thermal stability and mechanical strength. A notable example is its application in the development of high-performance polymer electrolytes for use in lithium-ion batteries.

In terms of chemical synthesis, 6-Ethoxy-2,3,4-trifluorobenzoic acid serves as a versatile starting material for a wide range of organic transformations. Its reactivity can be harnessed to introduce various functional groups onto the benzene ring, thereby expanding its utility in synthetic chemistry. For instance, it can be used as a precursor for the synthesis of fluorinated aromatic compounds with applications in agrochemicals and fine chemicals.

The synthesis of 6-Ethoxy-2,3,4-trifluorobenzoic acid typically involves multistep processes that include fluorination reactions and esterification steps. One common synthetic route involves the fluorination of 6-hydroxybenzoic acid followed by alkylation with ethyl iodide to introduce the ethoxy group. The resulting compound is then subjected to further functionalization to achieve the desired structure.

Safety and handling considerations are crucial when working with 6-Ethoxy-2,3,4-trifluorobenzoic acid. While it is not classified as a hazardous material under current regulations, proper precautions should be taken to ensure safe handling and storage. This includes using appropriate personal protective equipment (PPE) such as gloves and goggles, as well as working in well-ventilated areas to minimize exposure.

In conclusion, 6-Ethoxy-2,3,4-trifluorobenzoic acid (CAS No. 1980050-06-3) is a versatile compound with a wide range of potential applications in pharmaceuticals, materials science, and chemical synthesis. Its unique chemical structure and reactivity make it an important molecule for researchers and chemists working in these fields. Ongoing research continues to uncover new uses and properties of this compound, further solidifying its importance in modern chemistry.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)