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• 3. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Comprehensive Overview of (S)-Benzyl 3-Hydroxy-1-(methylamino)-1-oxopropan-2-ylcarbamate (CAS No. 19647-68-8)

(S)-Benzyl 3-Hydroxy-1-(methylamino)-1-oxopropan-2-ylcarbamate (CAS No. 19647-68-8) is a chiral organic compound widely recognized for its applications in pharmaceutical synthesis and biochemical research. This compound, often abbreviated as (S)-Benzyl carbamate derivative, features a unique stereochemical configuration that makes it valuable for asymmetric synthesis and enzyme inhibition studies. Its molecular structure includes a benzyl group, a hydroxypropane backbone, and a methylamino carbonyl moiety, contributing to its versatility in drug design.

In recent years, the demand for chiral intermediates like (S)-Benzyl 3-Hydroxy-1-(methylamino)-1-oxopropan-2-ylcarbamate has surged due to their role in developing targeted therapies and precision medicine. Researchers frequently search for "CAS 19647-68-8 suppliers" or "(S)-Benzyl carbamate synthesis" to source high-purity materials for peptide modification and protease inhibitor studies. The compound’s enantiomeric purity is critical for ensuring reproducibility in biocatalysis and kinetic resolution experiments.

From an industrial perspective, 19647-68-8 is often utilized in the production of bioactive molecules and pharmaceutical intermediates. Its carbamate-protected amine group enables selective reactions, making it a preferred choice for solid-phase peptide synthesis (SPPS). Laboratories focusing on drug discovery frequently explore its potential in structure-activity relationship (SAR) studies, particularly for G-protein-coupled receptor (GPCR) ligands.

The compound’s solubility profile (soluble in polar solvents like DMSO and methanol) and stability under inert conditions are frequently discussed in forums and scientific literature. Queries such as "how to store CAS 19647-68-8" or "(S)-Benzyl derivative reaction conditions" reflect user interest in optimizing its handling. Proper storage at -20°C in anhydrous environments is recommended to prevent degradation.

Emerging trends in green chemistry have also spotlighted (S)-Benzyl 3-Hydroxy-1-(methylamino)-1-oxopropan-2-ylcarbamate as a candidate for sustainable synthesis. Researchers are investigating catalytic asymmetric routes to reduce waste and improve atom economy. This aligns with the broader industry shift toward environmentally friendly protocols, a topic gaining traction in academic searches and conference presentations.

In summary, CAS No. 19647-68-8 represents a critical building block in modern organic and medicinal chemistry. Its applications span from peptide-based therapeutics to catalysis research, driven by its stereospecificity and functional group compatibility. As the scientific community continues to explore its potential, this compound remains a focal point for innovation in drug development and biochemical engineering.

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