• 1. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 4. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 5. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids Phenylpropanoic acids
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids

Comprehensive Overview of 2-(3-hydroxyphenyl)butanedioic acid (CAS No. 196195-42-3): Properties, Applications, and Research Insights

2-(3-hydroxyphenyl)butanedioic acid (CAS No. 196195-42-3) is a specialized organic compound with a growing presence in pharmaceutical and biochemical research. This hydroxyphenyl derivative is structurally characterized by a phenyl ring substituted with a hydroxyl group at the meta-position, coupled with a butanedioic acid (succinic acid) side chain. Its unique molecular architecture makes it a valuable intermediate in synthesizing bioactive molecules, particularly in drug discovery and metabolic pathway studies.

Recent trends in green chemistry and sustainable synthesis have amplified interest in compounds like 2-(3-hydroxyphenyl)butanedioic acid. Researchers are exploring its potential as a biobased building block for eco-friendly polymers and pharmaceutical excipients. The compound's carboxylic acid and phenolic hydroxyl functionalities enable diverse chemical modifications, aligning with the demand for multifunctional intermediates in precision medicine.

In analytical chemistry, CAS No. 196195-42-3 has gained attention for its role in HPLC method development and mass spectrometry calibration. Its UV-active aromatic moiety and ionizable groups make it suitable for chromatographic standards. A 2023 study in the Journal of Pharmaceutical Analysis highlighted its utility as a reference material for quantifying phenolic acids in plant extracts, addressing the booming market for natural product standardization.

The compound's structure-activity relationship (SAR) has been investigated in neuroprotective agent development. Molecular docking studies suggest its potential to interact with enzyme active sites involved in oxidative stress regulation. This aligns with current research priorities in neurodegenerative disease therapeutics, where phenolic acids are being evaluated for their antioxidant capacity and blood-brain barrier permeability.

From a regulatory perspective, 2-(3-hydroxyphenyl)butanedioic acid complies with major pharmacopeial standards for impurity profiling. Its well-defined spectroscopic fingerprints (FTIR, NMR) facilitate quality control in GMP manufacturing. The compound's logP value and aqueous solubility data are frequently requested in ADMET prediction queries, reflecting industry needs for computational chemistry inputs.

Emerging applications include its use in metal-chelating formulations for nutritional supplements and as a precursor for bioactive coatings in medical devices. Patent analyses reveal increasing filings incorporating CAS 196195-42-3 in controlled-release systems, particularly for gastrointestinal-targeted delivery of anti-inflammatory compounds.

Ongoing research is exploring the compound's microbial transformation potential using engineered enzymes, a hot topic in white biotechnology. Recent conferences have featured discussions on its role in cascade reactions for chiral synthesis, addressing the pharmaceutical industry's need for stereoselective methodologies.

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