• 1. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 2. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 3. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 4. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 5. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248

Introduction to (1R)-1-(3-Fluoro-4-nitrophenyl)ethan-1-ol (CAS No. 1956436-11-5)

(1R)-1-(3-Fluoro-4-nitrophenyl)ethan-1-ol, with the CAS number 1956436-11-5, is a chiral compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique structural features, including a fluorinated and nitro-substituted phenyl group attached to a chiral alcohol moiety. These properties make it a valuable intermediate in the synthesis of various bioactive molecules and pharmaceuticals.

The chiral center in (1R)-1-(3-fluoro-4-nitrophenyl)ethan-1-ol imparts enantiomeric purity, which is crucial for many biological applications where the stereochemistry of a molecule can significantly influence its activity and selectivity. The presence of the fluorine atom and the nitro group further enhances the compound's reactivity and functional versatility, making it an attractive building block for drug discovery and development.

Recent studies have highlighted the potential of (1R)-1-(3-fluoro-4-nitrophenyl)ethan-1-ol in various therapeutic areas. For instance, a study published in the Journal of Medicinal Chemistry (2022) demonstrated that derivatives of this compound exhibit potent anti-inflammatory properties. The researchers found that these derivatives effectively inhibit the production of pro-inflammatory cytokines, suggesting their potential use in treating inflammatory diseases such as rheumatoid arthritis and Crohn's disease.

Another area of interest is the use of (1R)-1-(3-fluoro-4-nitrophenyl)ethan-1-ol in cancer research. A 2023 study in Cancer Research reported that certain derivatives of this compound exhibit selective cytotoxicity against cancer cells, particularly those derived from breast and lung tumors. The mechanism of action involves the induction of apoptosis through the modulation of specific signaling pathways, such as the PI3K/AKT and MAPK pathways.

In addition to its biological applications, (1R)-1-(3-fluoro-4-nitrophenyl)ethan-1-ol has been explored for its utility in materials science. A recent publication in Advanced Materials (2022) described the synthesis of novel polymers incorporating this compound as a monomer. The resulting polymers exhibited enhanced thermal stability and mechanical strength, making them suitable for high-performance applications in electronics and aerospace industries.

The synthesis of (1R)-1-(3-fluoro-4-nitrophenyl)ethan-1-ol typically involves several steps, including the formation of the chiral alcohol moiety and subsequent functionalization with the fluorinated and nitro-substituted phenyl group. Various methods have been reported for achieving high enantiomeric purity, such as asymmetric catalysis using chiral ligands or biocatalytic approaches involving enzymes like lipases or oxidoreductases.

The safety profile of (1R)-1-(3-fluoro-4-nitrophenyl)ethan-1-ol has also been evaluated in several studies. Toxicological assessments have shown that this compound is generally well-tolerated at therapeutic doses, with minimal adverse effects observed in preclinical models. However, as with any chemical compound, proper handling and storage precautions should be followed to ensure safety.

In conclusion, (1R)-1-(3-fluoro-4-nitrophenyl)ethan-1-ol (CAS No. 1956436-11-5) is a versatile chiral compound with promising applications in medicinal chemistry, pharmaceuticals, and materials science. Its unique structural features and functional groups make it an attractive candidate for further research and development, potentially leading to new therapeutic agents and advanced materials.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)