• 1. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 2. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 3. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977

Introduction to cis-3-fluorocyclopentan-1-amine hydrochloride (CAS No. 1956377-21-1)

cis-3-fluorocyclopentan-1-amine hydrochloride, identified by the chemical abstracts service number (CAS No. 1956377-21-1), is a significant compound in the field of pharmaceutical chemistry. This compound belongs to the class of fluorinated cycloalkyl amines, which have garnered considerable attention due to their diverse biological activities and potential applications in drug development. The presence of a fluorine atom at the 3-position of the cyclopentane ring introduces unique electronic and steric properties, making this molecule a promising candidate for further exploration in medicinal chemistry.

The hydrochloride salt form of this compound enhances its solubility in aqueous solutions, facilitating its use in various biochemical assays and pharmaceutical formulations. This property is particularly advantageous for drug delivery systems where bioavailability and stability are critical factors. The structural motif of cis-3-fluorocyclopentan-1-amine suggests potential interactions with biological targets, such as enzymes and receptors, which are often modulated by fluorinated aromatic or heterocyclic compounds.

Recent advancements in computational chemistry and molecular modeling have enabled researchers to predict the binding affinity and mechanism of action of cis-3-fluorocyclopentan-1-amine hydrochloride with high precision. Studies indicate that the fluorine atom at the 3-position exerts a strong influence on the electronic distribution within the molecule, thereby modulating its reactivity and interaction with biological targets. This has opened up new avenues for designing drugs with enhanced potency and selectivity.

In the realm of drug discovery, fluorinated compounds are increasingly recognized for their ability to improve pharmacokinetic properties such as metabolic stability, lipophilicity, and binding affinity. The fluorocyclopentanamine scaffold has been explored in several therapeutic areas, including oncology, inflammation, and central nervous system disorders. Preliminary studies on cis-3-fluorocyclopentan-1-amine hydrochloride have shown promising results in preclinical models, suggesting its potential as a lead compound for further development.

The synthesis of cis-3-fluorocyclopentan-1-amine hydrochloride involves multi-step organic transformations that require careful optimization to ensure high yield and purity. Advanced synthetic methodologies, such as transition metal-catalyzed cross-coupling reactions and asymmetric hydrogenation, have been employed to construct the desired stereochemical configuration. The stereochemistry of the cis-isomer is crucial for its biological activity, as it determines the spatial arrangement of functional groups and their interaction with biological targets.

One of the most intriguing aspects of cis-3-fluorocyclopentan-1-amine hydrochloride is its potential role as a building block for more complex pharmacophores. By modifying the substituents on the cyclopentane ring or introducing additional functional groups, researchers can generate novel derivatives with tailored biological properties. Such derivatives may exhibit improved efficacy or reduced side effects compared to existing drugs.

The pharmaceutical industry has shown great interest in developing fluorinated amines due to their broad spectrum of biological activities. For instance, fluorinated amine derivatives have been investigated for their antimicrobial properties, where the fluorine atom enhances antibacterial activity by interfering with bacterial enzymes and cell wall synthesis. Similarly, in oncology research, fluorinated amines have been explored as inhibitors of kinases and other enzymes involved in cancer cell proliferation.

Regulatory agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have stringent guidelines for evaluating the safety and efficacy of new drug candidates. The development pipeline for cis-3-fluorocyclopentan-1-amine hydrochloride is currently undergoing rigorous preclinical testing to assess its pharmacological profile. These studies aim to gather comprehensive data on its absorption, distribution, metabolism, excretion (ADME), toxicity (TOX), and mechanism of action.

The integration of high-throughput screening (HTS) technologies has accelerated the identification of hits from large compound libraries, including those containing fluorinated cycloalkyl amines like cis-3-fluorocyclopentan-1-amine hydrochloride. HTS allows researchers to rapidly test thousands of compounds for their ability to modulate specific biological pathways or target proteins. This approach has been instrumental in identifying novel drug candidates that would otherwise remain undiscovered through traditional screening methods.

The role of computational tools in drug discovery cannot be overstated. Molecular docking simulations have been used to predict how cis-3-fluorocyclopentan-1-amine hydrochloride interacts with potential target proteins at an atomic level. These simulations provide insights into binding modes, affinity scores, and key interactions that contribute to its biological activity. Such information is invaluable for designing optimized analogs with improved pharmacological properties.

In conclusion,cis-3-fluorocyclopentan-1-amine hydrochloride represents a fascinating compound with significant potential in pharmaceutical research. Its unique structural features, combined with promising preclinical results, make it an attractive candidate for further development into a therapeutic agent. As research in this field continues to evolve,cis-isomers, like those derived from this compound,will likely play an increasingly important role in addressing unmet medical needs across various therapeutic areas.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)