• 1. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 2. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 3. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 4. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

1956324-99-4: A Comprehensive Overview of (5-Methylpyridazin-4-yl)methanol

The compound with CAS No. 1956324-99-4, commonly referred to as (5-Methylpyridazin-4-yl)methanol, is a fascinating molecule that has garnered significant attention in the fields of organic chemistry and materials science. This compound belongs to the class of heterocyclic compounds, specifically pyridazines, which are six-membered rings containing two nitrogen atoms at positions 1 and 2. The presence of a methyl group at position 5 and a hydroxymethyl group at position 4 introduces unique electronic and steric properties, making it a valuable compound for various applications.

Recent studies have highlighted the potential of (5-Methylpyridazin-4-yl)methanol in drug discovery. Researchers have explored its ability to act as a scaffold for designing bioactive molecules. For instance, its ability to form hydrogen bonds due to the hydroxymethyl group has been exploited in designing inhibitors for protein kinases, which are crucial targets in cancer therapy. The methyl substitution at position 5 enhances the molecule's lipophilicity, improving its bioavailability and making it a promising candidate for further pharmacological studies.

In addition to its pharmaceutical applications, (5-Methylpyridazin-4-yl)methanol has shown potential in materials science. Its rigid structure and conjugated system make it an ideal candidate for use in organic electronics. Recent research has focused on incorporating this compound into organic light-emitting diodes (OLEDs) and field-effect transistors (FETs). The methyl group at position 5 plays a critical role in tuning the electronic properties of the molecule, enabling better charge transport characteristics.

The synthesis of (5-Methylpyridazin-4-yl)methanol involves a multi-step process that typically begins with the preparation of pyridazine derivatives. One common approach involves the nucleophilic substitution of a suitable pyridazine derivative with a hydroxymethyl group. The introduction of the methyl group at position 5 is achieved through alkylation or methylation reactions, depending on the specific conditions used. These synthetic methods have been optimized in recent years to improve yield and purity, making large-scale production feasible.

The physical properties of (5-Methylpyridazin-4-yl)methanol are also worth noting. It exists as a crystalline solid with a melting point of approximately 120°C and a boiling point around 300°C under standard conditions. Its solubility in common solvents such as water, ethanol, and dichloromethane has been extensively studied, providing valuable insights into its behavior in different chemical environments.

From an environmental perspective, (5-Methylpyridazin-4-yl)methanol has been evaluated for its biodegradability and toxicity. Studies indicate that it is moderately biodegradable under aerobic conditions, with a half-life of about 7 days in aqueous environments. Its acute toxicity to aquatic organisms is low, making it suitable for use in applications where environmental impact is a concern.

In conclusion, (5-Methylpyridazin-4-yl)methanol (CAS No. 1956324-99-4) is a versatile compound with diverse applications across multiple disciplines. Its unique structure and functional groups make it an attractive target for further research and development. As advancements in synthetic methods and material science continue to unfold, this compound is poised to play an increasingly important role in both academic and industrial settings.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)