• 1. Reusable solid-phase supports for oligonucleotides and antisense therapeutics
  Richard T. Pon,Shuyuan Yu,Zhiqiang Guo,Ranjit Deshmukh,Yogesh S. Sanghvi J. Chem. Soc. Perkin Trans. 1 2001 2638
• 2. The synthesis of oligoribonucleotides. Part XI. Preparation of ribonucleoside 2′-acetal 3′-esters by selective deacylation
  Colin B. Reese,J. Charles M. Stewart,Jacques H. van Boom,Harry P. M. de Leeuw,Joek Nagel,Jan F. M. de Rooy J. Chem. Soc. Perkin Trans. 1 1975 934
• 3. Synthesis of the 3′-terminal half of yeast alanine transfer ribonucleic acid (tRNAAla) by the phosphotriester approach in solution. Part 1. Preparation of the nucleoside building blocks
  Jonathan M. Brown,Chris Christodoulou,Simon S. Jones,Anil S. Modak,Colin B. Reese,Samson Sibanda,Aiko Ubasawa J. Chem. Soc. Perkin Trans. 1 1989 1735
• 4. The protection of thymine and guanine residues in oligodeoxyribonucleotide synthesis
  Colin B. Reese,Philip A. Skone J. Chem. Soc. Perkin Trans. 1 1984 1263
• 5. Index pages
  Analyst 1934 59 A001

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Dicarboxylic acids and derivatives

Methoxyacetic Anhydride (CAS No. 19500-95-9): An Overview of Its Properties, Applications, and Recent Research

Methoxyacetic anhydride (CAS No. 19500-95-9) is a versatile compound with a wide range of applications in the chemical and pharmaceutical industries. This anhydride, also known as methoxyacetic acid anhydride, is a white crystalline solid at room temperature and is highly reactive due to its anhydride functional group. The compound is primarily used as an intermediate in the synthesis of various chemicals and pharmaceuticals, including esters, amides, and other derivatives.

The chemical structure of Methoxyacetic anhydride consists of a methoxy group (OCH₃) attached to an acetic acid anhydride moiety. This unique structure imparts specific chemical properties that make it valuable in various synthetic processes. The compound's reactivity is primarily attributed to the electrophilic nature of the anhydride group, which readily undergoes nucleophilic attack, leading to the formation of new chemical bonds.

In the pharmaceutical industry, Methoxyacetic anhydride is utilized in the synthesis of drugs and drug intermediates. Its ability to form esters and amides makes it a crucial reagent in the development of active pharmaceutical ingredients (APIs). Recent research has highlighted its role in the synthesis of novel compounds with potential therapeutic applications. For instance, a study published in the Journal of Medicinal Chemistry demonstrated the use of Methoxyacetic anhydride in the synthesis of a new class of anti-inflammatory agents with improved efficacy and reduced side effects.

Beyond pharmaceuticals, Methoxyacetic anhydride finds applications in other areas such as polymer science and materials science. In polymer chemistry, it is used as a cross-linking agent to enhance the mechanical properties and stability of polymers. Additionally, it has been explored for its potential in the development of advanced materials with specific functional properties. A recent study in the Journal of Polymer Science: Part A: Polymer Chemistry reported the use of Methoxyacetic anhydride to create novel polymer networks with enhanced thermal stability and mechanical strength.

The synthesis of Methoxyacetic anhydride can be achieved through several methods, including the reaction of methoxyacetic acid with acetic anhydride or through dehydration reactions involving methoxyacetic acid. These synthetic routes are well-documented in the literature and have been optimized for industrial-scale production. The choice of method often depends on factors such as cost, yield, and environmental impact.

In terms of safety and handling, while Methoxyacetic anhydride is not classified as a hazardous material under current regulations, it is important to follow standard laboratory safety protocols when working with this compound. Proper personal protective equipment (PPE) should be worn, and appropriate ventilation should be ensured to minimize exposure risks.

The environmental impact of Methoxyacetic anhydride is another area of ongoing research. Studies have shown that while the compound itself is not highly toxic to aquatic organisms, its degradation products may have varying environmental effects. Therefore, efforts are being made to develop more sustainable synthetic methods that minimize environmental impact. A recent review in the Green Chemistry Journal discussed several green chemistry approaches for the synthesis of Methoxyacetic anhydride, emphasizing the importance of reducing waste and improving process efficiency.

In conclusion, Methoxyacetic anhydride (CAS No. 19500-95-9) is a valuable compound with diverse applications in chemistry and pharmaceuticals. Its unique chemical properties make it a key intermediate in various synthetic processes, contributing to advancements in drug development, polymer science, and materials science. Ongoing research continues to explore new applications and more sustainable methods for its production, ensuring its continued relevance in these fields.

• 4480-83-5(Diglycolic anhydride)
• 94201-94-2(Acetic acid,2-(acetyloxy)-2-ethoxy-, ethyl ester)
• 119120-82-0(Acetic acid, (carboxymethoxy)-, anhydride)
• 648958-01-4(Ethyl, 1-(acetyloxy)-2-methoxy-2-oxo-)
• 25769-61-3(Glycolic Anhydride Diacetate)
• 65652-63-3(Acetic acid, 2,2'-[1,2-ethanediylbis(oxy)]bis-, diethyl ester)
• 14521-87-0(Acetic acid, 2-ethoxy-,anhydride with 2-ethoxyacetic acid)
• 131242-72-3(Acetic acid, methoxy-, 2-hydroxyethyl ester)
• 623-86-9(Ethyl Glycolate Acetate)
• 77022-98-1(3,6,9,12,15-Pentaoxaheptadecanedioic acid, 5,13-dioxo-)