• 1. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 2. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 3. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 5. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Aminophenyl ethers
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Introduction to 3-Methoxy-2-methylaniline (CAS No. 19500-02-8)

3-Methoxy-2-methylaniline, identified by its Chemical Abstracts Service (CAS) number 19500-02-8, is a significant organic compound with a rich history in pharmaceutical and chemical research. This aromatic amine derivative belongs to the class of methoxy-substituted anilines, which have garnered considerable attention due to their diverse applications in medicinal chemistry and material science. The structural features of 3-Methoxy-2-methylaniline, including its methoxy and methyl substituents on the benzene ring, contribute to its unique reactivity and utility in synthetic pathways.

The compound’s molecular structure consists of a benzene ring substituted at the 3-position with a methoxy group (-OCH?) and at the 2-position with a methyl group (-CH?). This arrangement imparts specific electronic and steric properties, making it a valuable intermediate in the synthesis of more complex molecules. The presence of both electron-donating methoxy and electron-withdrawing methyl groups allows for selective functionalization, enabling chemists to tailor its reactivity for various synthetic purposes.

In recent years, 3-Methoxy-2-methylaniline has been extensively studied for its potential applications in drug development. Its structural motif is reminiscent of several bioactive molecules, suggesting that it could serve as a precursor or scaffold for novel therapeutic agents. For instance, researchers have explored its utility in synthesizing derivatives with antimicrobial, anti-inflammatory, or even anticancer properties. The methoxy group, in particular, is known to enhance lipophilicity and metabolic stability, which are critical factors in drug design.

One of the most compelling aspects of 3-Methoxy-2-methylaniline is its role in the development of advanced materials. The compound’s aromatic nature and substituent pattern make it an excellent candidate for creating liquid crystals, organic semiconductors, and even components for organic light-emitting diodes (OLEDs). These applications leverage the compound’s ability to form stable π-stacking interactions, which are essential for the performance of many modern electronic devices.

Recent advancements in computational chemistry have further highlighted the importance of 3-Methoxy-2-methylaniline. Molecular modeling studies indicate that this compound can act as a key intermediate in multi-step synthetic routes, offering a more efficient pathway to complex molecules compared to traditional methods. Such insights have accelerated the discovery process in both academic and industrial research settings.

The pharmaceutical industry has also taken note of 3-Methoxy-2-methylaniline due to its potential as a building block for bioactive scaffolds. Researchers are particularly interested in its ability to undergo cross-coupling reactions, such as Suzuki or Buchwald-Hartwig couplings, which are pivotal in constructing biaryl structures found in many drugs. These reactions allow for the introduction of additional functional groups at precise positions on the aromatic ring, enabling fine-tuning of biological activity.

Another area where 3-Methoxy-2-methylaniline has shown promise is in the synthesis of agrochemicals. Its structural framework can be modified to produce herbicides or pesticides with improved efficacy and environmental safety. The methoxy group plays a crucial role here by influencing solubility and target specificity, making it an attractive feature for crop protection applications.

The chemical synthesis of 3-Methoxy-2-methylaniline itself has been optimized over time to achieve higher yields and purities. Modern synthetic protocols often employ catalytic methods that minimize waste and energy consumption, aligning with green chemistry principles. These advancements ensure that researchers have access to high-quality starting materials without compromising environmental standards.

In conclusion, 3-Methoxy-2-methylaniline (CAS No. 19500-02-8) is a versatile compound with broad applications across multiple scientific disciplines. Its unique structural features make it indispensable in pharmaceutical research, material science, and agrochemical development. As computational tools continue to refine synthetic strategies and new methodologies emerge, the importance of this compound is likely to grow even further.

• 34874-88-9(Benzenamine, 3-methoxy-2,4,6-trimethyl-)
• 946664-42-2(2-Methyl-4-(2-methylphenoxy)aniline)
• 857195-15-4(2-Methyl-3-Methoxyaniline Hydrochloride)
• 117174-70-6(4-Methoxy-2,5-dimethylaniline)
• 16452-01-0(3-Methoxy-4-methylaniline)
• 50868-72-9(5-Methoxy-2-methylaniline)
• 807262-85-7(Benzenamine,2,4,6-trimethyl-3-phenoxy-)
• 830321-17-0(Benzenamine, 4-(2,6-dimethylphenoxy)-2-methyl-)
• 223437-16-9(Phenol,3-amino-6-methoxy-2-methyl-)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)