• 1. A regioselective synthesis of 1-haloisoquinolines via ruthenium-catalyzed cyclization of O-methylbenzohydroximoyl halides with alkynes
  Ravi Kiran Chinnagolla,Sandeep Pimparkar,Masilamani Jeganmohan Chem. Commun. 2013 49 3703
• 2. 157. Synthetic antimalarials. Part XXVII. Some derivatives of phthalazine, quinoxaline, and isoquinoline
  Robert D. Haworth,Stanley Robinson J. Chem. Soc. 1948 777
• 3. A comparison of some pyrolysis reactions of benzotriazoles, benzisoxazolones and benzisothiazolones
  Wit K. Janowski,Rolf H. Prager,Jason A. Smith J. Chem. Soc. Perkin Trans. 1 2000 3212
• 4. 419. Cyanine dyes containing an isoquinoline nucleus
  Nellie I. Fisher,Frances M. Hamer J. Chem. Soc. 1934 1905
• 5. Synthesis and structures of complexes with axially chiral isoquinolinyl-naphtholate ligands
  Ruth H. Howard,Carlos Alonso-Moreno,Lewis M. Broomfield,David L. Hughes,Joseph A. Wright,Manfred Bochmann Dalton Trans. 2009 8667

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoquinolines and derivatives Isoquinolines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoquinolines and derivatives

Comprehensive Overview of 1-Chloroisoquinoline (CAS No. 19493-44-8): Properties, Applications, and Industry Insights

1-Chloroisoquinoline (CAS No. 19493-44-8) is a halogenated heterocyclic compound widely recognized for its versatility in organic synthesis and pharmaceutical research. This isoquinoline derivative features a chlorine atom at the 1-position, enhancing its reactivity in cross-coupling reactions and serving as a key intermediate for drug discovery. With the growing demand for small molecule therapeutics and catalysts, this compound has gained significant attention in academic and industrial laboratories.

The molecular structure of 1-Chloroisoquinoline enables diverse functionalization, making it valuable for constructing nitrogen-containing scaffolds—a hotspot in medicinal chemistry. Researchers frequently explore its role in synthesizing kinase inhibitors and antimicrobial agents, aligning with trends in targeted cancer therapy and antibiotic development. Its CAS No. 19493-44-8 is often searched in conjunction with "synthetic routes" and "safety data sheets," reflecting user interest in both innovation and regulatory compliance.

From a technical perspective, 1-Chloroisoquinoline exhibits a melting point of 45–48°C and a boiling point of 280°C under standard conditions. Its solubility in organic solvents like dichloromethane and tetrahydrofuran facilitates its use in palladium-catalyzed reactions, a topic frequently queried in AI-driven chemistry databases. Recent publications highlight its utility in Suzuki-Miyaura couplings, addressing the demand for green chemistry and atom-efficient protocols.

Market analytics reveal rising searches for "1-Chloroisoquinoline suppliers" and "CAS 19493-44-8 price," driven by expansion in contract research organizations (CROs). Quality benchmarks, such as HPLC purity (>98%) and storage conditions (2–8°C), are critical for buyers—a detail often emphasized in SEO-optimized product descriptions. The compound’s stability under inert atmospheres further supports its logistics-friendly profile.

Emerging applications include material science, where 1-Chloroisoquinoline derivatives contribute to organic semiconductors and light-emitting diodes (OLEDs). This aligns with global interest in sustainable electronics, a trending topic in Google Scholar and patent filings. Environmental considerations also spur studies on biodegradable intermediates, positioning this compound as a subject of life cycle assessment (LCA) research.

In summary, 1-Chloroisoquinoline (CAS No. 19493-44-8) bridges multiple scientific disciplines, from pharmaceutical manufacturing to advanced materials. Its structure-activity relationships and process scalability continue to inspire innovations, answering frequent search queries like "how to purify 1-Chloroisoquinoline" and "alternative halogenated isoquinolines." As industries prioritize high-value intermediates, this compound remains a cornerstone of modern synthetic chemistry.

• 21902-41-0(1,3,7-Trichloroisoquinoline)
• 15679-03-5(6-Chlorophenanthridine)
• 70810-23-0(1,5-Dichloroisoquinoline)
• 70810-24-1(1,7-Dichloroisoquinoline)
• 69042-30-4(1-Chloro-2,7-naphthyridine)
• 19493-45-9(3-Chloroisoquinoline)
• 7742-73-6(1,3-Dichloroisoquinoline)
• 32081-28-0(Benz[f]isoquinoline,4-chloro-)
• 52463-33-9(2,6-NAPHTHYRIDINE, 3-CHLORO-)
• 630421-73-7(1,6-Dichloroisoquinoline)