Cas no 194288-97-6 (4-(2-Fluorobenzyl)piperidine)
4-(2-Fluorobenzyl)piperidine is a fluorinated piperidine derivative widely used as a key intermediate in pharmaceutical and agrochemical synthesis. Its structure features a piperidine ring substituted with a 2-fluorobenzyl group, offering unique electronic and steric properties that enhance reactivity and selectivity in chemical transformations. The fluorine atom at the ortho position of the benzyl group improves metabolic stability and binding affinity in bioactive molecules, making it valuable for drug discovery. This compound is particularly useful in the development of CNS-targeting agents, enzyme inhibitors, and receptor modulators. High purity grades (≥98%) are available for research and industrial applications, ensuring reproducibility in synthetic processes. Its versatility and well-characterized reactivity profile make it a preferred building block in medicinal chemistry.
4-(2-Fluorobenzyl)piperidine structure
Product Name:4-(2-Fluorobenzyl)piperidine
CAS No:194288-97-6
MF:C12H16FN
MW:193.260546684265
CID:869409
PubChem ID:10775780
Update Time:2025-07-02
4-(2-Fluorobenzyl)piperidine Chemical and Physical Properties
Names and Identifiers
-
- 4-(2-Fluorobenzyl)piperidine
- 4-[(2-fluorophenyl)methyl]Piperidine
- RW2619
- DB-003938
- SCHEMBL3965587
- EN300-73658
- DTXSID50444758
- SB41923
- 194288-97-6
- AKOS011791284
- F8889-5912
- MFCD09756527
- HPTZGYXMDTTYBG-UHFFFAOYSA-N
- 4-[(2-fluorophenyl)-methyl]-piperidine
-
- MDL： MFCD09756527
- Inchi： 1S/C12H16FN/c13-12-4-2-1-3-11(12)9-10-5-7-14-8-6-10/h1-4,10,14H,5-9H2
- InChI Key： HPTZGYXMDTTYBG-UHFFFAOYSA-N
- SMILES： FC1C=CC=CC=1CC1CCNCC1
Computed Properties
- Exact Mass: 193.12700
- Monoisotopic Mass: 193.126677677g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 1
- Heavy Atom Count: 14
- Rotatable Bond Count: 2
- Complexity: 166
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.6
- Topological Polar Surface Area: 12?2
Experimental Properties
- Density: 1.044±0.06 g/cm3 (20 oC 760 Torr),
- Boiling Point: 281.0±20.0 oC (760 Torr),
- Flash Point: 123.7±21.8 oC,
- Solubility: Very slightly soluble (0.72 g/l) (25 o C),
- PSA: 12.03000
- LogP: 2.69660
4-(2-Fluorobenzyl)piperidine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM179209-1g |
4-(2-fluorobenzyl)piperidine |
194288-97-6 | 95% | 1g |
$408 | 2021-08-05 | |
| Chemenu | CM179209-1g |
4-(2-fluorobenzyl)piperidine |
194288-97-6 | 95% | 1g |
$398 | 2023-01-09 | |
| Alichem | A129004799-1g |
4-(2-Fluorobenzyl)piperidine |
194288-97-6 | 95% | 1g |
$369.60 | 2023-09-02 | |
| Enamine | EN300-73658-0.05g |
4-[(2-fluorophenyl)methyl]piperidine |
194288-97-6 | 95.0% | 0.05g |
$19.0 | 2025-03-21 | |
| Enamine | EN300-73658-0.1g |
4-[(2-fluorophenyl)methyl]piperidine |
194288-97-6 | 95.0% | 0.1g |
$26.0 | 2025-03-21 | |
| Enamine | EN300-73658-0.25g |
4-[(2-fluorophenyl)methyl]piperidine |
194288-97-6 | 95.0% | 0.25g |
$38.0 | 2025-03-21 | |
| Enamine | EN300-73658-0.5g |
4-[(2-fluorophenyl)methyl]piperidine |
194288-97-6 | 95.0% | 0.5g |
$60.0 | 2025-03-21 | |
| Enamine | EN300-73658-1.0g |
4-[(2-fluorophenyl)methyl]piperidine |
194288-97-6 | 95.0% | 1.0g |
$77.0 | 2025-03-21 | |
| Enamine | EN300-73658-2.5g |
4-[(2-fluorophenyl)methyl]piperidine |
194288-97-6 | 95.0% | 2.5g |
$147.0 | 2025-03-21 | |
| Enamine | EN300-73658-5.0g |
4-[(2-fluorophenyl)methyl]piperidine |
194288-97-6 | 95.0% | 5.0g |
$264.0 | 2025-03-21 |
4-(2-Fluorobenzyl)piperidine Related Literature
-
Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
-
Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
-
Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
-
Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
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