• 1. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
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• 2. Fate of single walled carbon nanotubes in wetland ecosystems?
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• 3. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 4. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
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• 5. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoquinolines and derivatives Isoquinolines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoquinolines and derivatives

3,7-Dibromoisoquinoline (CAS No. 1935586-13-2): A Versatile Building Block in Organic Synthesis

3,7-Dibromoisoquinoline (CAS No. 1935586-13-2) is a highly valuable heterocyclic compound that has gained significant attention in the field of organic chemistry and pharmaceutical research. As a brominated isoquinoline derivative, this compound serves as a crucial intermediate in the synthesis of various biologically active molecules and functional materials. The presence of two bromine atoms at the 3 and 7 positions of the isoquinoline ring makes it an excellent substrate for further functionalization through cross-coupling reactions, nucleophilic substitutions, and other modern synthetic transformations.

The growing interest in 3,7-dibromoisoquinoline applications stems from its unique structural features that allow for diverse chemical modifications. Researchers frequently search for "3,7-dibromoisoquinoline synthesis" and "1935586-13-2 properties" as this compound plays a pivotal role in developing novel drug candidates, particularly in the areas of kinase inhibitors and antimicrobial agents. Its rigid aromatic system with two strategically placed halogen atoms enables efficient construction of complex molecular architectures through palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig couplings.

In recent years, the demand for high purity 3,7-dibromoisoquinoline has increased substantially due to its applications in material science. The compound's ability to participate in the formation of conjugated systems makes it valuable for creating organic semiconductors and luminescent materials. Many researchers investigating "isoquinoline derivatives in OLEDs" or "heterocyclic building blocks for electronic materials" have found this brominated derivative particularly useful. The electron-withdrawing nature of the bromine atoms also enhances its utility in designing charge-transport materials for optoelectronic devices.

The physicochemical properties of 3,7-dibromoisoquinoline contribute to its widespread use in medicinal chemistry. With a molecular weight of 286.96 g/mol and characteristic solubility in common organic solvents, this compound offers excellent handling properties for laboratory applications. Analytical data including "3,7-dibromoisoquinoline NMR spectrum" and "1935586-13-2 HPLC purity" are frequently requested by quality control departments in pharmaceutical companies, highlighting its importance in drug discovery pipelines.

From a synthetic chemistry perspective, 3,7-dibromoisoquinoline serves as a key precursor for numerous nitrogen-containing heterocycles. The compound's reactivity pattern allows for selective functionalization at either bromine position, enabling the construction of diverse molecular libraries. Recent publications exploring "metal-catalyzed reactions of dibromoisoquinolines" demonstrate how this scaffold can be transformed into various pharmacophores through innovative synthetic strategies. Its stability under various reaction conditions makes it particularly attractive for multistep syntheses.

The commercial availability of 3,7-dibromoisoquinoline has improved significantly in response to growing market demand. Suppliers now offer this compound with various purity grades, from standard laboratory quality to ultra-high purity for sensitive applications. Customers often inquire about "3,7-dibromoisoquinoline price" and "bulk quantities of CAS 1935586-13-2," reflecting its transition from a specialty chemical to a more mainstream research reagent. Proper storage conditions typically recommend protection from light and moisture to maintain long-term stability.

In the context of green chemistry initiatives, researchers have developed more sustainable approaches to 3,7-dibromoisoquinoline preparation. Modern synthetic routes focus on reducing hazardous byproducts and improving atom economy while maintaining high yields. These advancements align with the pharmaceutical industry's increasing emphasis on "environmentally friendly heterocycle synthesis" and "green chemistry in drug development." The compound's versatility continues to inspire new methodologies that balance efficiency with environmental considerations.

Quality control aspects of 3,7-dibromoisoquinoline remain crucial for its successful application. Standard characterization includes comprehensive spectroscopic analysis (1H NMR, 13C NMR, mass spectrometry) and chromatographic purity assessment. The scientific community values detailed "3,7-dibromoisoquinoline characterization data" to ensure reproducibility in research applications. Many suppliers now provide extensive analytical certificates with each batch, including residual solvent analysis and heavy metal content verification.

The future outlook for 3,7-dibromoisoquinoline (CAS 1935586-13-2) appears promising as new applications continue to emerge. Its role in developing kinase inhibitors for cancer therapy and antimicrobial agents positions it as a valuable tool in addressing global health challenges. Additionally, its potential in materials science for organic electronics and energy storage devices suggests expanding utility beyond traditional pharmaceutical applications. As synthetic methodologies advance and demand grows, this compound will likely maintain its status as an essential building block in modern chemical research and development.

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