• 1. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 3. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 4. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 5. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives

Comprehensive Guide to 6-Methoxypyridine-3-carbonyl chloride (CAS No. 193538-78-2): Properties, Applications, and Market Insights

6-Methoxypyridine-3-carbonyl chloride (CAS No. 193538-78-2) is a specialized heterocyclic compound widely used in pharmaceutical and agrochemical research. This carbonyl chloride derivative is gaining attention due to its versatile reactivity, making it a valuable intermediate in organic synthesis. With the increasing demand for pyridine-based compounds in drug discovery, understanding the properties and applications of this chemical is essential for researchers and industry professionals.

The molecular structure of 6-Methoxypyridine-3-carbonyl chloride features a methoxy group at the 6-position and a reactive carbonyl chloride moiety at the 3-position of the pyridine ring. This unique arrangement allows it to participate in various nucleophilic acyl substitution reactions, making it a key building block for synthesizing more complex molecules. Recent studies highlight its role in developing kinase inhibitors and antiviral agents, aligning with current trends in targeted drug therapies.

One of the most searched questions about 6-Methoxypyridine-3-carbonyl chloride is its stability and handling. While it is sensitive to moisture, proper storage under inert conditions ensures its longevity. Researchers often inquire about its solubility profile—it is soluble in common organic solvents like dichloromethane and THF, but insoluble in water. These properties are critical when planning multi-step synthetic routes in medicinal chemistry projects.

In the pharmaceutical industry, 193538-78-2 is frequently employed to construct biologically active pyridine derivatives. For example, it serves as a precursor for 6-methoxynicotinic acid, a scaffold found in several experimental drugs targeting inflammatory diseases. The compound’s relevance has surged with the growing interest in small-molecule therapeutics, particularly those addressing protein-protein interactions—a hot topic in recent drug development conferences.

Beyond pharmaceuticals, 6-Methoxypyridine-3-carbonyl chloride finds applications in material science, where its electron-rich pyridine core contributes to designing organic semiconductors and ligands for catalysis. Its compatibility with cross-coupling reactions (e.g., Suzuki-Miyaura) makes it attractive for creating conjugated polymers used in OLED technologies. This dual utility in life sciences and advanced materials underscores its interdisciplinary importance.

Market analysts note a steady rise in demand for high-purity 193538-78-2, driven by R&D investments in precision medicine and green chemistry. Suppliers are increasingly offering customized batch synthesis services to meet diverse research needs. Environmental considerations also prompt innovations in solvent-free activation methods for this compound, reflecting broader industry shifts toward sustainable practices.

For researchers troubleshooting synthesis protocols, a common challenge involves optimizing yield of 6-Methoxypyridine-3-carbonyl chloride while minimizing byproducts. Recent publications suggest that controlling reaction temperature and using anhydrous conditions significantly improve efficiency. These practical insights are often sought in organic chemistry forums and patent literature.

In summary, 6-Methoxypyridine-3-carbonyl chloride (CAS No. 193538-78-2) represents a critical tool for modern chemical innovation. Its adaptability across drug discovery, materials engineering, and sustainable chemistry positions it at the forefront of applied heterocyclic chemistry. As AI-assisted molecule design gains traction, compounds like this will continue to bridge computational predictions with laboratory reality.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)