• 1. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 2. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 3. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 4. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 5. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084

3-Bromo-4-Methylbenzene-1-Sulfonyl Fluoride: A Comprehensive Overview

3-Bromo-4-Methylbenzene-1-Sulfonyl Fluoride, also known by its CAS No. 1934861-95-6, is a versatile organic compound with significant applications in various fields of chemistry. This compound belongs to the family of sulfonyl fluorides, which are widely used as intermediates in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. The structure of this compound comprises a benzene ring substituted with a bromine atom at the 3-position, a methyl group at the 4-position, and a sulfonyl fluoride group at the 1-position. This unique combination of substituents imparts distinctive chemical properties to the molecule, making it highly valuable in modern chemical research and industry.

The synthesis of 3-Bromo-4-Methylbenzene-1-Sulfonyl Fluoride typically involves multi-step processes that require precise control over reaction conditions. Recent advancements in synthetic methodologies have enabled chemists to optimize the production of this compound, ensuring higher yields and improved purity. For instance, researchers have explored the use of microwave-assisted synthesis and catalytic systems to streamline the reaction pathways. These innovations not only enhance the efficiency of the synthesis but also reduce environmental impact by minimizing waste generation.

One of the most notable applications of 3-Bromo-4-Methylbenzene-1-Sulfonyl Fluoride is in drug discovery. The sulfonyl fluoride group is a common motif in bioactive molecules due to its ability to act as a leaving group in substitution reactions. This property makes it an ideal precursor for constructing sulfonamide derivatives, which are extensively studied for their potential therapeutic effects. Recent studies have highlighted its role in developing inhibitors for kinases and other enzyme targets, underscoring its importance in modern pharmacology.

In addition to its role in drug development, 3-Bromo-4-Methylbenzene-1-Sulfonyl Fluoride is also utilized in materials science. The bromine and methyl substituents on the benzene ring contribute to its electronic and steric properties, making it suitable for applications in polymer chemistry and nanotechnology. Researchers have explored its use as a building block for constructing functional polymers with tailored properties, such as high thermal stability or conductivity.

The physical and chemical properties of 3-Bromo-4-Methylbenzene-1-Sulfonyl Fluoride have been extensively characterized using advanced analytical techniques. For example, nuclear magnetic resonance (NMR) spectroscopy has provided insights into its molecular structure, while mass spectrometry has confirmed its molecular weight and composition. These studies have not only validated the compound's identity but also provided critical data for its safe handling and storage.

In terms of safety considerations, proper handling of 3-Bromo-4-Methylbenzene-1-Sulfonyl Fluoride is essential due to its reactive nature. It is recommended to handle this compound under inert atmospheres and to use appropriate personal protective equipment (PPE) such as gloves and goggles. Storage should be in tightly sealed containers away from moisture and heat sources to prevent degradation or accidental exposure.

The demand for 3-Bromo-4-Methylbenzene-1-Sulfonyl Fluoride continues to grow as researchers uncover new applications across diverse disciplines. Its unique combination of substituents makes it a valuable tool for advancing chemical research and industrial processes. As technology evolves, we can expect further innovations that will expand the utility of this compound even further.

• 1935075-89-0(2-bromo-3-methylbenzene-1-sulfonyl fluoride)
• 1934815-12-9(2,5-dibromo-4-methylbenzene-1-sulfonyl fluoride)
• 1934412-10-8(3-Bromo-4-cyanobenzene-1-sulfonyl fluoride)
• 498-83-9(4-Bromobenzenesulfonyl fluoride)
• 2302146-38-7(5-bromo-2,4-dimethylbenzene-1-sulfonyl fluoride)
• 1186204-62-5(3-bromo-2-methylbenzene-1-sulfonyl fluoride)
• 1934392-03-6(3-bromo-5-methylbenzene-1-sulfonyl fluoride)
• 1030832-29-1(4-bromo-3-methylbenzene-1-sulfonyl fluoride)
• 2137643-42-4(4-Bromo-2,5-dimethylbenzenesulfonyl fluoride)
• 454-65-9(3-Bromobenzenesulfonyl fluoride)