• 1. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 3. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 4. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 5. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

Professional Introduction to 3-Fluoro-4-methylbenzyl alcohol (CAS No. 192702-79-7)

3-Fluoro-4-methylbenzyl alcohol, identified by its Chemical Abstracts Service (CAS) number 192702-79-7, is a significant compound in the realm of pharmaceutical and chemical research. This compound, featuring a benzyl alcohol moiety with both fluoro and methyl substituents, has garnered attention due to its versatile applications in synthetic chemistry and drug development. The unique structural attributes of this molecule make it a valuable intermediate in the synthesis of various pharmacologically active agents.

The benzyl alcohol backbone in 3-fluoro-4-methylbenzyl alcohol contributes to its solubility and reactivity, making it a preferred choice for organic synthesis. The presence of a fluoro group at the 3-position and a methyl group at the 4-position introduces specific electronic and steric effects that can influence the compound's interactions with biological targets. These features have been exploited in recent research to develop novel therapeutic agents with enhanced efficacy and selectivity.

In recent years, there has been a growing interest in fluorinated aromatic compounds due to their ability to modulate metabolic stability and binding affinity. The fluoro group in 3-fluoro-4-methylbenzyl alcohol, for instance, has been shown to improve the bioavailability of certain drugs by reducing their susceptibility to metabolic degradation. This property has made it a valuable building block in the design of next-generation pharmaceuticals.

One of the most compelling applications of 3-fluoro-4-methylbenzyl alcohol is in the synthesis of kinase inhibitors. Kinases are enzymes that play a crucial role in many cellular processes, and their dysregulation is often associated with various diseases, including cancer. By incorporating this compound into drug candidates, researchers have been able to develop inhibitors that target specific kinases with high precision. For example, derivatives of 3-fluoro-4-methylbenzyl alcohol have been investigated as potential treatments for tyrosine kinases, which are overactive in many forms of cancer.

Another area where 3-fluoro-4-methylbenzyl alcohol has shown promise is in the development of antiviral agents. The fluoro group's ability to enhance binding affinity has been leveraged to create compounds that can inhibit viral replication. In particular, research has focused on using this compound as a precursor for synthesizing inhibitors of viral proteases and polymerases. These inhibitors are essential for disrupting the life cycle of viruses, thereby providing new avenues for antiviral therapy.

The synthetic pathways involving 3-fluoro-4-methylbenzyl alcohol are also noteworthy. The compound can be readily prepared through various methods, including Friedel-Crafts alkylation followed by reduction and fluorination. These synthetic routes are well-documented and have been optimized for high yield and purity. The ease with which this compound can be synthesized makes it an attractive choice for both academic research and industrial applications.

In conclusion, 3-fluoro-4-methylbenzyl alcohol (CAS No. 192702-79-7) is a multifaceted compound with significant potential in pharmaceutical research. Its unique structural features make it an invaluable intermediate for synthesizing drugs targeting various diseases, including cancer and viral infections. As research continues to uncover new applications for this compound, its importance in the chemical and pharmaceutical industries is likely to grow even further.

• 75853-18-8(2,3-Difluorobenzyl alcohol)
• 75853-20-2((2,5-difluorophenyl)methanol)
• 430431-55-3(Methanediol, (3-fluoro-4-methylphenyl)- (9CI))
• 26583-82-4(Benzenemethanol,3-fluoro-2,4-dimethyl-)
• 252004-32-3((2,6-Difluoro-4-methyl-phenyl)-methanol)
• 307975-03-7(2-Fluoro-3-methylbenzyl alcohol)
• 252004-43-6((2,5-Difluoro-4-methylphenyl)methanol)
• 500912-13-0(3-Fluoro-2-methylbenzyl alcohol)
• 446-51-5(2-Fluorobenzyl Alcohol)
• 261951-66-0((4-Fluoro-3-methylphenyl)methanol)