• 1. Synthesis and in vitro enzyme activity of peptide derivatives of bacterial cell wall biosynthesis inhibitors
  Russell J. Cox,Helen Jenkins,James A. Schouten,Rosie A. Stentiford,Katrina J. Wareing J. Chem. Soc. Perkin Trans. 1 2000 2023

N-Acetyl-L-Alanine: A Comprehensive Overview

N-Acetyl-L-Alanine (CAS No. 19245-87-5) is a biologically significant compound that has garnered attention in various fields, including biochemistry, pharmacology, and nutrition. This compound, also known as N-acetyl-L-alanyl, is a derivative of the amino acid L-alanine, with an acetyl group attached to the nitrogen atom. Its unique structure and functional properties make it a valuable molecule in both research and industrial applications.

N-Acetyl-L-Alanine is notable for its role in peptide synthesis and as a precursor in various biochemical pathways. Recent studies have highlighted its potential in enhancing cellular energy production and supporting metabolic processes. For instance, research published in the *Journal of Medicinal Chemistry* has demonstrated that N-acetyl-L-alanyl derivatives can act as efficient substrates for enzymes involved in energy metabolism, particularly in conditions such as mitochondrial dysfunction.

The synthesis of N-Acetyl-L-Alanine involves the acetylation of L-alanine using acetic anhydride or other suitable acylating agents. This process is typically carried out under controlled conditions to ensure high purity and stability of the final product. The compound's physical properties, such as its solubility in water and organic solvents, make it suitable for various applications in pharmaceutical formulations and nutraceuticals.

In the field of nutrition, N-Acetyl-L-Alanine has been explored as a functional ingredient in sports nutrition products. It is believed to enhance muscle recovery and reduce fatigue by modulating amino acid metabolism. A study conducted by researchers at the University of California revealed that supplementation with N-acetyl-L-alanyl can improve exercise performance by increasing intracellular levels of key metabolites involved in energy production.

Moreover, N-Acetyl-L-Alanine has shown promise in the development of novel therapeutic agents. Its ability to penetrate cellular membranes efficiently makes it a potential carrier for drug delivery systems. Recent advancements in nanotechnology have enabled the use of N-acetyl-L-alanyl as a component in lipid nanoparticles, enhancing the bioavailability of encapsulated drugs.

From a structural perspective, N-Acetyl-L-Alanine consists of an acetyl group attached to the amino nitrogen of L-alanine. This modification imparts unique chemical properties, such as increased lipophilicity, which enhances its bioavailability when administered orally. The compound's stereochemistry is also critical, with the L-form being biologically active and predominant in natural systems.

Recent research has also focused on the antioxidant properties of N-Acetyl-L-Alanine. Studies have shown that it can scavenge reactive oxygen species (ROS) and protect cells from oxidative damage. This property makes it a potential candidate for use in skincare products aimed at combating oxidative stress-induced aging.

In conclusion, N-Acetyl-L-Alanine (CAS No. 19245-87-5) is a versatile compound with diverse applications across multiple disciplines. Its role as a building block in peptide synthesis, its potential in drug delivery systems, and its antioxidant properties highlight its significance in both academic research and industrial development. As ongoing studies continue to uncover new insights into its functionality, N-acetyl-L-alanyl is poised to play an even greater role in advancing healthcare and nutrition.

• 820962-06-9(L-Alanine, glycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl- (9CI))
• 6745-19-3(D-Alanine,L-alanyl-L-alanyl-)
• 820962-03-6(L-Alanine,glycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-)
• 820962-02-5(L-Alanine,glycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-)
• 820962-07-0(L-Alanine, glycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-)
• 820962-05-8(L-Alanine, glycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl- (9CI))
• 820962-04-7(L-Alanine,glycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-L-alanylglycyl-)
• 6491-25-4(H-GLY-ALA-ALA-OH)
• 62074-99-1(Alanine, N-acetylalanyl-)
• 926-79-4(L-Alanyl-L-Alanyl-L-Alanyl-L-Alanine)