Cas no 191724-12-6 (4-(3-Trifluoromethylphenyl)phenol)

4-(3-Trifluoromethylphenyl)phenol is a fluorinated aromatic compound featuring a phenol group substituted with a 3-(trifluoromethyl)phenyl moiety. This structure imparts unique physicochemical properties, including enhanced lipophilicity and electron-withdrawing effects due to the trifluoromethyl group. The compound is valuable in organic synthesis, particularly as an intermediate in pharmaceuticals, agrochemicals, and advanced materials. Its trifluoromethyl group improves metabolic stability and bioavailability in drug development. The phenol functionality allows for further derivatization, enabling applications in cross-coupling reactions, polymer synthesis, and ligand design. High purity grades ensure consistency in research and industrial processes. Its stability under various conditions makes it suitable for demanding synthetic applications.
4-(3-Trifluoromethylphenyl)phenol structure
191724-12-6 structure
Product Name:4-(3-Trifluoromethylphenyl)phenol
CAS No:191724-12-6
MF:C13H9F3O
MW:238.205174207687
MDL:MFCD06801898
CID:1086084
PubChem ID:20099597
Update Time:2025-10-28

4-(3-Trifluoromethylphenyl)phenol Chemical and Physical Properties

Names and Identifiers

    • 3'-(Trifluoromethyl)-[1,1'-biphenyl]-4-ol
    • 4-[3-(trifluoromethyl)phenyl]phenol
    • 4-(3-TrifluoroMethylphenyl)phenol
    • DTXSID30602379
    • CS-0209449
    • 3'-(trifluoromethyl)[1,1'-biphenyl]-4-ol
    • BS-21976
    • F83035
    • [1,1'-Biphenyl]-4-ol, 3'-(trifluoromethyl)-
    • 3 inverted exclamation mark -(Trifluoromethyl)-[1,1 inverted exclamation mark -biphenyl]-4-ol
    • DB-394484
    • AKOS002678479
    • MFCD06801898
    • SCHEMBL322980
    • 191724-12-6
    • SY356255
    • 3'-(trifluoromethyl)biphenyl-4-ol
    • 4-(3-Trifluoromethylphenyl)phenol
    • MDL： MFCD06801898
    • Inchi： 1S/C13H9F3O/c14-13(15,16)11-3-1-2-10(8-11)9-4-6-12(17)7-5-9/h1-8,17H
    • InChI Key： CZUSUCKUEGOGJO-UHFFFAOYSA-N
    • SMILES： FC(C1=CC=CC(=C1)C1C=CC(=CC=1)O)(F)F

Computed Properties

  • Exact Mass: 238.06054939g/mol
  • Monoisotopic Mass: 238.06054939g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 1
  • Complexity: 244
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.1
  • Topological Polar Surface Area: 20.2?2

4-(3-Trifluoromethylphenyl)phenol Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
T900845-50mg
4-(3-Trifluoromethylphenyl)phenol
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50mg
 $ 50.00 2022-06-02
TRC
T900845-100mg
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 $ 65.00 2022-06-02
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abcr
AB318915-1 g
4-(3-Trifluoromethylphenyl)phenol, 95%; .
 191724-12-6 95%
1g
 €246.00 2023-04-26
eNovation Chemicals LLC
Y1234865-1g
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[1,1'-Biphenyl]-4-ol, 3'-(trifluoromethyl)-
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eNovation Chemicals LLC
Y1234865-250mg
[1,1'-Biphenyl]-4-ol, 3'-(trifluoromethyl)-
 191724-12-6 95%
250mg
 $125 2025-02-20
abcr
AB318915-1g
4-(3-Trifluoromethylphenyl)phenol, 95%; .
 191724-12-6 95%
1g
 €246.00 2025-02-21
1PlusChem
1P002FW6-100mg
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 191724-12-6 95%
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4-(3-Trifluoromethylphenyl)phenol Related Literature

Additional information on 4-(3-Trifluoromethylphenyl)phenol

4-(3-Trifluoromethylphenyl)phenol (CAS No. 191724-12-6): Properties, Applications, and Market Insights

4-(3-Trifluoromethylphenyl)phenol (CAS No. 191724-12-6) is a specialized organic compound with a molecular formula of C13H9F3O. This compound, also known as 3-(4-Hydroxyphenyl)-α,α,α-trifluorotoluene, is gaining attention in various industrial and research applications due to its unique chemical properties. The presence of the trifluoromethyl group (-CF3) and the phenolic hydroxyl group (-OH) makes it a versatile intermediate in organic synthesis.

The physical and chemical properties of 4-(3-Trifluoromethylphenyl)phenol include a molecular weight of 238.21 g/mol, a melting point range of 80-85°C, and moderate solubility in organic solvents like ethanol, acetone, and dichloromethane. Its thermal stability and chemical reactivity make it suitable for high-performance applications, particularly in the pharmaceutical and material science sectors.

One of the most common questions researchers ask is: "What are the key applications of 4-(3-Trifluoromethylphenyl)phenol?" This compound is widely used as a building block in the synthesis of advanced materials, including liquid crystals, polymers, and agrochemicals. Its fluorinated aromatic structure enhances the thermal and chemical resistance of final products, making it valuable in high-tech industries.

In the pharmaceutical field, 4-(3-Trifluoromethylphenyl)phenol serves as a crucial intermediate for developing bioactive molecules. Recent studies highlight its potential in designing anti-inflammatory agents and central nervous system (CNS) drugs. The trifluoromethyl group improves the metabolic stability and bioavailability of drug candidates, addressing a key challenge in modern drug discovery.

Another trending topic is the environmental impact of fluorinated compounds. While 4-(3-Trifluoromethylphenyl)phenol is not classified as hazardous, researchers are exploring sustainable synthesis methods to minimize waste and energy consumption. Green chemistry approaches, such as catalytic fluorination and solvent-free reactions, are being investigated to enhance the eco-friendliness of its production.

The market demand for 4-(3-Trifluoromethylphenyl)phenol is steadily growing, driven by its applications in electronics, coatings, and specialty chemicals. Analysts project a compound annual growth rate (CAGR) of 5-7% over the next five years, with Asia-Pacific emerging as a key production and consumption region. Companies are investing in scalable synthesis routes to meet the rising demand from end-user industries.

For researchers and manufacturers, understanding the quality standards of 4-(3-Trifluoromethylphenyl)phenol is critical. High-purity grades (>98%) are essential for pharmaceutical and electronic applications, while technical grades are sufficient for industrial uses. Analytical techniques like HPLC, GC-MS, and NMR spectroscopy are commonly employed to verify purity and structural integrity.

In summary, 4-(3-Trifluoromethylphenyl)phenol (CAS No. 191724-12-6) is a multifunctional compound with significant potential across diverse sectors. Its unique chemical structure, combined with evolving synthesis technologies, positions it as a valuable asset in modern chemistry. As industries continue to innovate, the role of this compound is expected to expand, offering new opportunities for research and commercialization.

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