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Comprehensive Guide to Ethyl 2-(4-nitrophenoxy)acetate (CAS No. 19076-89-2): Properties, Applications, and Market Insights

Ethyl 2-(4-nitrophenoxy)acetate (CAS No. 19076-89-2) is a specialized organic compound widely recognized in the fields of pharmaceutical intermediates, agrochemical synthesis, and specialty chemicals. This ester derivative, featuring a 4-nitrophenoxy group, has garnered significant attention due to its versatile reactivity and applications in fine chemical manufacturing. Researchers and industry professionals frequently search for "Ethyl 2-(4-nitrophenoxy)acetate uses" or "CAS 19076-89-2 synthesis," reflecting its importance in synthetic chemistry.

The molecular structure of Ethyl 2-(4-nitrophenoxy)acetate combines an ethyl ester moiety with a nitrophenoxy substituent, making it valuable for nucleophilic substitution reactions. Its chemical formula, C₁₀H₁₁NO₅, and molecular weight of 225.20 g/mol are critical identifiers for laboratory and industrial applications. Recent trends show growing interest in "green synthesis of nitrophenoxy derivatives" and "sustainable esterification methods," aligning with global demands for eco-friendly chemical processes.

In pharmaceutical research, Ethyl 2-(4-nitrophenoxy)acetate serves as a key intermediate for designing drug candidates, particularly in antimicrobial and anti-inflammatory agents. Its nitro-aromatic component enhances binding affinity in target molecules, a topic often explored in queries like "nitrophenoxy compounds in drug discovery." Additionally, agrochemical manufacturers utilize this compound to develop novel pesticides with improved efficacy, addressing the rising demand for "crop protection chemicals" in precision agriculture.

The compound's physical properties include a pale-yellow crystalline appearance, melting point range of 45–50°C, and solubility in organic solvents like ethanol and acetone. These characteristics are frequently searched under terms such as "Ethyl 2-(4-nitrophenoxy)acetate solubility" or "CAS 19076-89-2 specifications," highlighting its practical handling requirements. Analytical techniques like HPLC and GC-MS are commonly employed for purity verification, ensuring compliance with industry standards.

Market analyses reveal increasing procurement of Ethyl 2-(4-nitrophenoxy)acetate by Asian and European chemical suppliers, driven by expansions in pharmaceutical R&D and agrochemical production. Searches for "bulk suppliers of nitrophenoxy acetates" or "19076-89-2 price trends" reflect its commercial significance. Regulatory compliance, particularly concerning REACH and FDA guidelines, remains a critical discussion point for global trade.

Innovative applications of Ethyl 2-(4-nitrophenoxy)acetate extend to material science, where it acts as a monomer for synthesizing specialty polymers with UV-stabilizing properties. This aligns with trending searches for "high-performance polymer additives" and "nitro-functionalized materials." Environmental studies also explore its biodegradation pathways, responding to queries about "eco-friendly degradation of aromatic esters."

Handling and storage recommendations emphasize protection from moisture and light, with searches like "stable storage conditions for nitrophenoxy esters" being prevalent. The compound's compatibility with common reagents such as Grignard compounds and reducing agents makes it a staple in synthetic toolkits, as seen in technical forums discussing "ester functional group transformations."

Future research directions for Ethyl 2-(4-nitrophenoxy)acetate include catalytic asymmetric synthesis and flow chemistry adaptations, topics gaining traction under "continuous flow nitrophenoxy reactions." Collaborative studies between academia and industry continue to uncover novel derivatives, reinforcing its role in advancing molecular innovation while adhering to safety and sustainability benchmarks.

• 138563-69-6(Acetic acid, (3-nitrophenoxy)-, 1,1-dimethylethyl ester)
• 31252-86-5(Acetic acid, methoxy-, 4-nitrophenyl ester)
• 556038-14-3(Acetic acid, 2,2'-[1,3-phenylenebis(oxy)]bis-, bis(4-nitrophenyl) ester)
• 59820-64-3(Acetic acid, (4-amino-3-nitrophenoxy)-, ethyl ester)
• 1798-11-4(4-Nitrophenoxyacetic Acid)
• 6941-80-6( )
• 5544-77-4((3-nitrophenoxy) acetic acid ethyl ester)
• 128438-79-9(Acetic acid, (4-methoxyphenoxy)-, 4-nitrophenyl ester)
• 19786-48-2(Methyl 4-Nitrophenoxyacetate)
• 62171-64-6(Acetic acid, phenoxy-, 4-nitrophenyl ester)