• 1. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 2. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 3. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 4. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
• 5. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Dicarboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Potassium Ethoxy(oxo)acetate (CAS No. 1906-57-6): A Comprehensive Overview

Potassium Ethoxy(oxo)acetate (CAS No. 1906-57-6) is a versatile compound with significant applications in various fields, including organic synthesis, pharmaceuticals, and materials science. This compound, also known as potassium ethyl oxalate or potassium ethyl oxamate, is a white crystalline solid that is highly soluble in water and ethanol. Its unique chemical structure and properties make it an essential reagent in many synthetic pathways and industrial processes.

The molecular formula of Potassium Ethoxy(oxo)acetate is C₄H₇KO₄, and its molecular weight is approximately 164.20 g/mol. The compound consists of a potassium ion (K⁺) and the ethoxy(oxo)acetate anion (C₄H₆O₄^-). The ethoxy(oxo)acetate anion features a central carbon atom bonded to an oxygen atom, an ethoxy group (OCH₂CH₃), and a carboxyl group (COO^-). This structural arrangement confers the compound with unique reactivity and solubility characteristics.

In organic synthesis, Potassium Ethoxy(oxo)acetate is widely used as a versatile reagent for the preparation of various organic compounds. It serves as an excellent nucleophile in substitution reactions, particularly in the synthesis of esters and amides. Recent studies have highlighted its role in the development of novel synthetic methods for the preparation of complex organic molecules. For instance, a study published in the Journal of Organic Chemistry demonstrated the use of Potassium Ethoxy(oxo)acetate in the efficient synthesis of substituted pyridines, which are important intermediates in pharmaceutical research.

In the pharmaceutical industry, Potassium Ethoxy(oxo)acetate has gained attention for its potential applications in drug discovery and development. Its ability to participate in various chemical reactions makes it a valuable tool for the synthesis of drug candidates. Research has shown that this compound can be used to synthesize prodrugs, which are biologically inactive derivatives that are converted into active drugs within the body. This approach can improve the pharmacokinetic properties of drugs, such as their solubility and bioavailability.

Beyond its use in organic synthesis and pharmaceuticals, Potassium Ethoxy(oxo)acetate has also found applications in materials science. It is used as a precursor for the synthesis of metal-organic frameworks (MOFs), which are highly porous materials with potential applications in gas storage, catalysis, and drug delivery. A recent study published in Advanced Materials reported the successful synthesis of MOFs using Potassium Ethoxy(oxo)acetate, demonstrating its utility in creating materials with tailored properties.

The safety and handling of Potassium Ethoxy(oxo)acetate are important considerations for its use in laboratory and industrial settings. While it is generally considered safe when handled properly, it is important to follow standard safety protocols to avoid exposure to skin or eyes and to ensure proper ventilation during use. The compound should be stored in a cool, dry place away from incompatible materials.

In conclusion, Potassium Ethoxy(oxo)acetate (CAS No. 1906-57-6) is a multifaceted compound with a wide range of applications in organic synthesis, pharmaceuticals, and materials science. Its unique chemical properties make it an indispensable reagent in various synthetic pathways and industrial processes. Ongoing research continues to uncover new uses and potential applications for this versatile compound, further solidifying its importance in the scientific community.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)