• 1. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 2. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 3. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 4. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 5. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143

7-Fluoroquinazolin-2-Amine: A Comprehensive Overview

7-Fluoroquinazolin-2-Amine (CAS No. 190274-01-2) is a fascinating compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound, with its unique structural features and versatile applications, has become a focal point for researchers aiming to explore its potential in drug discovery and advanced material synthesis. In this article, we delve into the properties, synthesis, applications, and recent advancements related to 7-fluoroquinazolin-2-amine, providing a comprehensive understanding of its significance in modern scientific research.

The chemical structure of 7-fluoroquinazolin-2-amine is characterized by a quinazoline ring system with a fluorine atom at the 7-position and an amino group at the 2-position. This arrangement imparts unique electronic and steric properties to the molecule, making it highly versatile for various applications. The quinazoline core is a well-known heterocyclic structure that has been extensively studied due to its role in natural products, pharmaceuticals, and synthetic materials. The introduction of a fluorine atom at the 7-position further enhances the compound's reactivity and selectivity, making it an attractive candidate for medicinal chemistry and material science.

Recent studies have highlighted the potential of 7-fluoroquinazolin-2-amine as a building block for constructing bioactive molecules. Researchers have demonstrated that this compound can be readily functionalized to generate derivatives with enhanced pharmacokinetic profiles and improved biological activity. For instance, fluorinated quinazolines have shown promise as inhibitors of various enzymes, including kinases and proteases, which are critical targets in the development of anti-cancer and anti-inflammatory drugs.

In addition to its role in drug discovery, 7-fluoroquinazolin-2-amine has also found applications in materials science. The compound's ability to form stable coordination complexes with metal ions has made it a valuable component in the synthesis of metal-organic frameworks (MOFs) and other advanced materials. These materials exhibit exceptional porosity and stability, making them ideal for gas storage, catalysis, and sensing applications.

The synthesis of 7-fluoroquinazolin-2-amine typically involves multi-step processes that require precise control over reaction conditions to ensure high yields and purity. Traditional methods often rely on nucleophilic aromatic substitution or condensation reactions, but recent advancements have introduced more efficient routes that minimize side reactions and improve scalability. For example, microwave-assisted synthesis has been employed to accelerate reaction times while maintaining product quality.

One of the most exciting developments in the study of 7-fluoroquinazolin-2-amine is its use as a precursor for constructing fluorescent probes. By incorporating this compound into conjugated systems, researchers have developed sensors capable of detecting specific analytes with high sensitivity and selectivity. These probes have found applications in environmental monitoring, food safety, and biomedical diagnostics.

Furthermore, 7-fluoroquinazolin-2-amine has been investigated for its potential as an advanced material in optoelectronic devices. The compound's ability to absorb light across a broad spectrum makes it a promising candidate for use in solar cells and light-emitting diodes (LEDs). Recent studies have demonstrated that derivatives of this compound can achieve high quantum yields under UV excitation, paving the way for their integration into next-generation optoelectronic devices.

In conclusion, 7-fluoroquinazolin-2-amine (CAS No. 190274-01-2) is a versatile compound with a wide range of applications across multiple scientific disciplines. Its unique chemical properties make it an invaluable tool for researchers working in drug discovery, materials science, and beyond. As ongoing studies continue to uncover new possibilities for this compound, it is clear that 7-fluoroquinazolin-2-amine will remain at the forefront of scientific innovation for years to come.

• 88368-33-6(7H-Pyrimido[5,4-c]carbazole, 10-fluoro-)
• 16499-43-7(Quinazoline, 5-fluoro-)
• 190273-81-5(5-Fluoroquinazolin-2-amine)
• 16499-45-9(7-Fluoroquinazoline)
• 190274-25-0(8-Fluoroquinazolin-2-amine)
• 30486-73-8(6-fluoro-1H-1,3-benzodiazol-2-amine)
• 119584-78-0(2,4-Quinazolinediamine,7-fluoro-)
• 16499-44-8(6-Fluoroquinazoline)
• 20028-72-2(6-fluoroquinazolin-2-amine)
• 190273-85-9(5,6-Difluoroquinazolin-2-amine)