Cas no 190249-87-7 (Fmoc-aminooxy-PEG2-NH2)

Fmoc-aminooxy-PEG2-NH2 is a bifunctional PEG-based reagent featuring an Fmoc-protected aminooxy group and a terminal primary amine. The aminooxy moiety enables efficient oxime ligation with aldehydes or ketones, while the amine group facilitates further conjugation via standard coupling chemistry. The short PEG2 spacer enhances solubility and reduces steric hindrance, making it suitable for bioconjugation and peptide/protein modification. The Fmoc group provides orthogonality for selective deprotection in solid-phase synthesis. This compound is particularly useful in click chemistry, glycoconjugate synthesis, and the preparation of functionalized biomaterials, offering versatility in controlled derivatization strategies. Its stability and reactivity profile make it a valuable tool for researchers in chemical biology and drug development.
Fmoc-aminooxy-PEG2-NH2 structure
Fmoc-aminooxy-PEG2-NH2 structure
Product Name:Fmoc-aminooxy-PEG2-NH2
CAS No:190249-87-7
MF:C19H22N2O5
MW:358.3884
CID:4767198
PubChem ID:88541230
Update Time:2026-02-26

Fmoc-aminooxy-PEG2-NH2 Chemical and Physical Properties

Names and Identifiers

    • Fmoc-aminooxy-PEG2-NH2
    • CS-0144694
    • HY-131955
    • SCHEMBL9955379
    • 9H-fluoren-9-ylmethyl N-[2-(2-aminooxyethoxy)ethoxy]carbamate
    • 190249-87-7
    • F82792
    • DA-73491
    • Fmoc-NH-PEG2-NH2
    • PD171078
    • (9H-fluoren-9-yl)methyl N-{2-[2-(aminooxy)ethoxy]ethoxy}carbamate
    • MS-25635
    • Inchi： 1S/C19H22N2O5/c20-25-11-9-23-10-12-26-21-19(22)24-13-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-8,18H,9-13,20H2,(H,21,22)
    • InChI Key： PJENKAHPGFOITB-UHFFFAOYSA-N
    • SMILES： O(C(N([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])ON([H])[H])=O)C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C12

Computed Properties

  • Exact Mass: 358.15287181g/mol
  • Monoisotopic Mass: 358.15287181g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 26
  • Rotatable Bond Count: 10
  • Complexity: 414
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.1
  • Topological Polar Surface Area: 92

Fmoc-aminooxy-PEG2-NH2 Pricemore >>

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Fmoc-aminooxy-PEG2-NH2 Related Literature

Related Categories

Additional information on Fmoc-aminooxy-PEG2-NH2

Comprehensive Overview of Fmoc-aminooxy-PEG2-NH2 (CAS No. 190249-87-7): Applications and Innovations

The compound Fmoc-aminooxy-PEG2-NH2 (CAS No. 190249-87-7) is a highly versatile PEG-based linker widely utilized in bioconjugation, drug delivery, and peptide synthesis. Its unique structure combines an Fmoc-protected aminooxy group with a PEG2 spacer and a terminal primary amine, making it invaluable for researchers in pharmaceutical development and biomaterials engineering. This article delves into its properties, applications, and relevance to cutting-edge scientific trends.

One of the most searched topics in bioconjugation chemistry revolves around site-specific modification of biomolecules. Fmoc-aminooxy-PEG2-NH2 addresses this need by enabling controlled attachment of carbohydrates, proteins, or small molecules via its aminooxy group, which reacts selectively with aldehyde or ketone functionalities. The PEG2 spacer enhances solubility and reduces steric hindrance, a feature frequently queried in forums discussing linker optimization.

In the context of ADC (Antibody-Drug Conjugate) development, a trending focus in cancer therapeutics, this compound’s dual-functional design allows for sequential conjugation strategies. Researchers often search for "PEG linkers for ADCs" or "amine-to-oxime coupling"—keywords that align with the capabilities of CAS No. 190249-87-7. Its Fmoc protection further ensures compatibility with solid-phase peptide synthesis (SPPS), a technique central to peptide-based drug discovery.

The rise of click chemistry and bioorthogonal reactions has amplified interest in aminooxy-PEG derivatives. Users frequently ask about "stable PEG linkers for in vivo applications" or "Fmoc deprotection conditions." Here, Fmoc-aminooxy-PEG2-NH2 stands out due to its hydrolytic stability and ease of Fmoc removal under mild basic conditions, topics heavily debated in chemical synthesis communities.

Beyond therapeutics, this compound finds utility in diagnostic probe design, particularly for fluorescence labeling and surface immobilization. Its PEG2 unit minimizes nonspecific binding—a key concern in biosensor development. Searches like "PEG spacers for ELISA" or "amine-reactive probes" highlight its cross-disciplinary relevance.

Environmental and green chemistry trends also intersect with Fmoc-aminooxy-PEG2-NH2. With growing searches for "sustainable bioconjugation reagents," its water-soluble PEG backbone aligns with efforts to reduce organic solvent use. Moreover, its high purity (>95% by HPLC) meets stringent demands in GMP-compliant manufacturing, a hotspot in regulatory discussions.

In summary, Fmoc-aminooxy-PEG2-NH2 (CAS No. 190249-87-7) bridges multiple scientific frontiers—from targeted drug delivery to materials science. Its adaptability to trending techniques like SPPS and click chemistry, coupled with its PEG-enhanced biocompatibility, ensures its continued prominence in both academic and industrial research.

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