• 1. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 2. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 3. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 4. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 5. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organic Halides

Diisopropylcarbamoyl Chloride (CAS No. 19009-39-3): A Versatile Reagent in Chemical and Pharmaceutical Research

Diisopropylcarbamoyl chloride, identified by the CAS number 19009-39-3, is an organochloride compound with significant applications in organic synthesis and drug development. This compound, characterized by its carbamoyl chloride functional group (-N(COCl)), serves as a critical intermediate for synthesizing bioactive molecules and pharmaceutical agents. Recent advancements in synthetic methodologies have highlighted its role in enhancing reaction efficiency and selectivity, particularly in the context of peptide conjugation and small-molecule drug design.

The structural versatility of diisopropylcarbamoyl chloride stems from its ability to form stable amide bonds under mild conditions. Researchers have leveraged this property to develop novel strategies for site-specific protein labeling, a technique pivotal for studying protein-protein interactions and post-translational modifications. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that this compound enables efficient coupling with primary amines, yielding high-purity amide derivatives with minimal side reactions—a breakthrough for producing biopharmaceuticals like monoclonal antibodies.

In the realm of drug discovery, CAS 19009-39-3-based compounds have shown promise in modulating enzyme activity through targeted covalent inhibition. For instance, recent investigations into kinase inhibitors revealed that incorporating diisopropylcarbamoyl chloride into lead compounds enhances their binding affinity to target proteins while reducing off-target effects. This approach has been applied to design potential therapeutics for cancer and neurodegenerative diseases, as highlighted in a collaborative study between Stanford University and Genentech.

The synthesis of diisopropylcarbamoyl chloride has also evolved with green chemistry principles. Traditional methods often relied on hazardous reagents, but modern protocols now utilize recyclable catalysts and solvent systems. A notable example is the palladium-catalyzed carbonylation process reported in Nature Catalysis (2024), which reduces waste production by over 60% while maintaining product yield. Such innovations align with global sustainability goals while ensuring scalability for industrial applications.

Beyond synthesis, this compound plays a role in material science through its use in polymer functionalization. Researchers at MIT recently employed it to create stimuli-responsive hydrogels capable of controlled drug release under physiological conditions. The hydrolytic stability of amide linkages formed via CAS No. 19009-39-3 ensures these materials maintain structural integrity during prolonged biomedical applications.

In clinical research contexts, derivatives of diisopropylcarbamoyl chloride are being explored as prodrugs to improve pharmacokinetic profiles. By temporarily masking polar groups through carbamate esterification, these prodrugs enhance membrane permeability before undergoing enzymatic activation within the body—a strategy validated in preclinical trials targeting inflammatory disorders.

Safety data from recent toxicity studies underscores its controlled handling requirements while emphasizing that proper precautions align with standard laboratory protocols for organic chlorides. Regulatory compliance frameworks such as REACH have been instrumental in guiding safe storage and disposal practices without compromising research utility.

Ongoing collaborations between academic institutions and pharmaceutical companies continue to expand the utility of this compound across diverse fields—from improving vaccine adjuvants to optimizing CRISPR-based gene editing tools via targeted delivery systems. Its integration into high-throughput screening platforms further accelerates early-stage drug development pipelines.

The interdisciplinary applications of CAS No. 19009-39-3-designated diisopropylcarbamoyl chloride exemplify how foundational chemical reagents drive innovation at the intersection of chemistry, biology, and medicine. As synthetic methodologies advance alongside computational modeling tools like molecular docking simulations, this compound remains a cornerstone for addressing complex challenges in modern healthcare solutions.

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