• 1. An inter-tangled network of redox-active and conducting polymers as a cathode for ultrafast rechargeable batteries
  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
• 2. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 3. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 4. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells?
  Xue-Ying Wang,Ying Pei,Min Xie,Zi-He Jin,Ya-Shi Xiao,Yang Wang,Li-Na Zhang,Yan Li,Wei-Hua Huang Lab Chip, 2015,15, 1178-1187
• 5. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644

Recent Advances in the Study of 3,4-Dichlorobenzyl Isothiocyanate (CAS: 18967-42-5) in Chemical Biology and Medicine

3,4-Dichlorobenzyl isothiocyanate (CAS: 18967-42-5) has emerged as a compound of significant interest in chemical biology and medicinal research due to its unique structural properties and potential therapeutic applications. This brief synthesizes recent findings (2021-2023) regarding its molecular mechanisms, biological activities, and pharmacological potential, with particular attention to its role as a modulator of cellular signaling pathways.

A 2022 study published in Journal of Medicinal Chemistry demonstrated the compound's potent inhibitory effects on NF-κB signaling through covalent modification of cysteine residues in IKKβ (IC50 = 1.8 μM). Structural analysis revealed that the dichlorinated benzyl group enhances membrane permeability while the isothiocyanate moiety enables targeted protein modification. This dual functionality positions 18967-42-5 as a promising scaffold for anti-inflammatory drug development.

In cancer research, preclinical models have shown remarkable selectivity of 3,4-Dichlorobenzyl Isothiocyanate against triple-negative breast cancer cells (MDA-MB-231) with minimal toxicity to normal mammary epithelial cells (MCF-10A). A 2023 ACS Chemical Biology publication identified its activation of Nrf2-mediated antioxidant responses as a key mechanism for inducing apoptosis in cancer stem cells (EC50 = 3.2 μM). These findings suggest potential applications in combination therapies with conventional chemotherapeutics.

The compound's antimicrobial properties have also been investigated. Recent work in Bioorganic Chemistry (2023) reported broad-spectrum activity against drug-resistant Gram-positive pathogens (MIC = 4-8 μg/mL against MRSA), with mechanistic studies indicating disruption of bacterial membrane integrity and inhibition of sortase A activity. This positions 18967-42-5 as a potential lead compound for addressing antibiotic resistance challenges.

From a chemical biology perspective, researchers have developed novel bioconjugation strategies using 3,4-Dichlorobenzyl Isothiocyanate as a versatile probe for protein labeling. Its optimal balance between reactivity and stability (half-life = 4.7 hours in physiological buffer) makes it particularly useful for studying protein-protein interactions in live cells, as demonstrated in recent Nature Chemical Biology studies.

Ongoing clinical translation efforts face challenges including optimizing pharmacokinetic properties and reducing potential off-target effects. However, structural derivatives of 18967-42-5 showing improved bioavailability (AUC increased by 3.2-fold in rodent models) suggest promising avenues for therapeutic development. Current research priorities include elucidating structure-activity relationships and exploring synergistic combinations with existing therapies.

The accumulating evidence positions 3,4-Dichlorobenzyl Isothiocyanate as a multifunctional agent with applications spanning anti-inflammatory therapies, oncology, infectious disease, and chemical biology tools. Future research directions should focus on target identification, mechanism elucidation, and translational development to fully realize its therapeutic potential.

• 3694-45-9(4-Chlorobenzyl isothiocyanate)
• 206559-49-1(Benzene, 2-chloro-4-(isothiocyanatomethyl)-1-methyl-)
• 18967-41-4(2,4-Dichlorobenzyl Isothiocyanate)
• 18967-44-7(2-Chlorobenzyl isothiocyanate)
• 737000-80-5((R)-(-)-1-(4-CHLOROPHENYL)ETHYL ISOTHIOCYANATE)
• 737000-81-6((S)-(+)-1-(4-CHLOROPHENYL)ETHYL ISOTHIOCYANATE)
• 86841-89-6(1-Chloro-4-(1-isothiocyanatoethyl)benzene)
• 58971-22-5(Benzene, 1,2-dichloro-4-(2-isothiocyanatoethyl)-)
• 84341-72-0(Benzenemethanamine, 4-chloro-N-methylene-)
• 3694-58-4(3-Chlorobenzyl Isothiocyanate)