• 1. Rational design of selective inhibitors of PARP4
  Ilsa T. Kirby,Ashley Person,Michael Cohen RSC Med. Chem. 2021 12 1950

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

Introduction to (4-Chloropyridin-3-yl)methanol (CAS No. 189449-41-0)

The compound (4-Chloropyridin-3-yl)methanol, identified by the CAS number 189449-41-0, is a versatile organic compound with significant applications in various fields, including pharmaceuticals, agrochemicals, and materials science. This compound is characterized by its unique structure, which combines a pyridine ring substituted with a chlorine atom at the 4-position and a hydroxymethyl group at the 3-position. The presence of these functional groups makes it highly reactive and amenable to a wide range of chemical transformations.

Recent advancements in synthetic chemistry have enabled the efficient synthesis of (4-Chloropyridin-3-yl)methanol. Researchers have explored various methodologies, including nucleophilic aromatic substitution and catalytic hydrogenation, to optimize the production process. These studies have not only improved yield but also reduced the environmental footprint of manufacturing this compound. The ability to synthesize this compound in large quantities has further expanded its potential applications.

In the pharmaceutical industry, (4-Chloropyridin-3-yl)methanol has shown promise as an intermediate in drug discovery programs. Its structure provides a scaffold for developing bioactive molecules with potential therapeutic effects. For instance, studies have demonstrated that derivatives of this compound exhibit anti-inflammatory and antioxidant properties, making them valuable candidates for treating chronic diseases such as neurodegenerative disorders and cardiovascular conditions.

Beyond pharmaceuticals, this compound has also found applications in agrochemicals. Its ability to interact with biological systems makes it a potential candidate for developing pesticides and herbicides. Recent research has focused on understanding its mechanism of action in pest control, particularly its role in disrupting insect nervous systems. These findings highlight its potential as an eco-friendly alternative to traditional chemical pesticides.

The material science community has also taken interest in (4-Chloropyridin-3-yl)methanol due to its unique electronic properties. Studies have shown that derivatives of this compound can be used as building blocks for advanced materials, such as conductive polymers and organic semiconductors. These materials hold great promise for applications in flexible electronics and optoelectronic devices.

In conclusion, (4-Chloropyridin-3-yl)methanol (CAS No. 189449-41-0) is a multifaceted compound with diverse applications across various industries. Its structural features, combined with recent advancements in synthesis and application development, position it as a key player in modern chemical research. As ongoing studies continue to uncover new properties and uses, this compound is likely to play an increasingly important role in shaping future innovations.

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