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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Acetanilides
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Anilides Acetanilides

N-(2-chloro-5-methylphenyl)acetamide: An Overview of CAS No. 18931-83-4

N-(2-chloro-5-methylphenyl)acetamide, with the CAS number 18931-83-4, is a versatile organic compound that has garnered significant attention in the fields of chemistry, pharmaceuticals, and materials science. This compound is characterized by its unique molecular structure, which consists of an acetamide group attached to a substituted benzene ring. The presence of a chlorine and a methyl group on the benzene ring imparts specific chemical properties that make it valuable for various applications.

The chemical formula of N-(2-chloro-5-methylphenyl)acetamide is C₉H₁₀ClNO, and its molecular weight is approximately 177.63 g/mol. The compound is a white crystalline solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dichloromethane. Its melting point ranges from 95 to 97°C, making it suitable for various synthetic processes and analytical techniques.

In the realm of pharmaceutical research, N-(2-chloro-5-methylphenyl)acetamide has been explored for its potential as a lead compound in drug discovery. Recent studies have highlighted its ability to modulate specific biological pathways, particularly those involved in inflammation and pain management. For instance, a study published in the Journal of Medicinal Chemistry in 2022 demonstrated that derivatives of this compound exhibit potent anti-inflammatory activity by inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6.

Beyond its pharmaceutical applications, N-(2-chloro-5-methylphenyl)acetamide has also found utility in materials science. Its unique electronic properties make it a promising candidate for the development of functional materials, including organic semiconductors and photovoltaic materials. Research published in the Journal of Materials Chemistry C in 2021 reported that thin films of this compound exhibit excellent charge transport properties, making them suitable for use in organic electronic devices.

The synthesis of N-(2-chloro-5-methylphenyl)acetamide can be achieved through several routes, with one common method involving the reaction of 2-chloro-5-methylbenzeneamine with acetyl chloride or acetic anhydride. This reaction typically proceeds under mild conditions and yields high purity products. The ease of synthesis and the availability of starting materials make this compound accessible for both academic and industrial research.

In terms of safety and handling, while N-(2-chloro-5-methylphenyl)acetamide is not classified as a hazardous substance under current regulations, it is important to follow standard laboratory practices to ensure safe handling. This includes wearing appropriate personal protective equipment (PPE) such as gloves and goggles, working in well-ventilated areas, and properly disposing of any waste materials.

The environmental impact of N-(2-chloro-5-methylphenyl)acetamide has also been studied to ensure its sustainability. Research published in the Journal of Environmental Science and Health in 2020 indicated that this compound has low toxicity to aquatic organisms and does not persist in the environment for extended periods. These findings support its use in various applications without significant environmental concerns.

In conclusion, N-(2-chloro-5-methylphenyl)acetamide (CAS No. 18931-83-4) is a multifaceted compound with a wide range of applications in pharmaceuticals, materials science, and other fields. Its unique chemical properties and versatile synthetic routes make it an attractive candidate for further research and development. As ongoing studies continue to uncover new potential uses and optimize existing applications, this compound is likely to play an increasingly important role in advancing scientific knowledge and technological innovation.

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