Cas no 189307-15-1 (Mogroside VI)

Mogroside VI structure
Mogroside VI structure
Product Name:Mogroside VI
CAS No:189307-15-1
MF:C66H112O34
MW:1449.59
CID:222594
PubChem ID:101552120
Update Time:2025-05-26

Mogroside VI Chemical and Physical Properties

Names and Identifiers

    • b-D-Glucopyranoside, (3b,9b,10a,11a,24R)-11,25-dihydroxy-9-methyl-19-norlanost-5-ene-3,24-diylbis[O-b-D-glucopyranosyl-(1?2)-O-[b-D-glucopyranosyl-(1?6)]- (9CI)
    • Neomogroside
    • (3beta,9beta,10alpha,11alpha,24R)-11,25-Dihydroxy-9-methyl-19-norlanost-5-ene-3,24-diyl bis[O-beta-D-glucopyranosyl-(1→2)-O-[beta-D-glucopyranosyl-(1→6)]-beta-D-glucopyranoside
    • Mogroside VI
    • DTXSID601317961
    • AKOS040760562
    • 189307-15-1
    • Inchi： InChI=1S/C66H112O34/c1-24(9-13-37(63(4,5)88)98-61-55(100-59-53(87)47(81)41(75)31(21-70)94-59)49(83)43(77)33(96-61)23-90-57-51(85)45(79)39(73)29(19-68)92-57)25-15-16-64(6)34-12-10-26-27(66(34,8)35(71)17-65(25,64)7)11-14-36(62(26,2)3)97-60-54(99-58-52(86)46(80)40(74)30(20-69)93-58)48(82)42(76)32(95-60)22-89-56-50(84)44(78)38(72)28(18-67)91-56/h10,24-25,27-61,67-88H,9,11-23H2,1-8H3/t24-,25-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36+,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47+,48+,49+,50-,51-,52-,53-,54-,55-,56-,57-,58+,59+,60+,61+,64+,65-,66+/m1/s1
    • InChI Key： LTDANPHZAHSOBN-QYTMKXBISA-N
    • SMILES： C1C[C@@]2([H])[C@]3(C)[C@H](O)C[C@]4(C)[C@@H]([C@@H](CC[C@@H](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)O5)C(O)(C)C)C)CC[C@@]4(C)[C@@]3([H])CC=C2C(C)(C)[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)O1

Computed Properties

  • Exact Mass: 1448.7035006g/mol
  • Monoisotopic Mass: 1448.7035006g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 22
  • Hydrogen Bond Acceptor Count: 34
  • Heavy Atom Count: 100
  • Rotatable Bond Count: 23
  • Complexity: 2690
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 40
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -5.3
  • Topological Polar Surface Area: 556?2

Experimental Properties

  • Density: 1.55±0.1 g/cm3 (20 oC 760 Torr),
  • Solubility: Insuluble (1.4E-3 g/L) (25 oC),

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Mogroside VI Related Literature

Related Categories

Additional information on Mogroside VI

Recent Advances in Mogroside VI (189307-15-1) Research: A Comprehensive Review

Mogroside VI (CAS: 189307-15-1), a bioactive compound derived from Siraitia grosvenorii (monk fruit), has garnered significant attention in the chemical, biological, and pharmaceutical fields due to its potential therapeutic applications. Recent studies have focused on its structural properties, biosynthesis pathways, and pharmacological effects, particularly its role as a natural sweetener with anti-diabetic, anti-inflammatory, and anti-oxidative properties. This research brief synthesizes the latest findings to provide a comprehensive overview of Mogroside VI's current research landscape.

Structural analysis of Mogroside VI reveals a unique triterpenoid saponin configuration, which contributes to its high sweetness intensity (approximately 250-300 times sweeter than sucrose) and low caloric content. Advances in chromatographic techniques, such as HPLC-MS and NMR spectroscopy, have enabled precise quantification and purity assessment of Mogroside VI in complex matrices. Recent publications in journals like Journal of Agricultural and Food Chemistry highlight optimized extraction methods using ultrasonic-assisted ethanol extraction, yielding higher purity and efficiency.

Pharmacological studies have demonstrated Mogroside VI's potential in managing metabolic disorders. A 2023 study published in Phytomedicine reported its ability to enhance insulin sensitivity in vitro by activating AMPK pathways in adipocytes. Additionally, its anti-inflammatory effects were validated in a murine model of colitis, where Mogroside VI reduced pro-inflammatory cytokines (TNF-α, IL-6) by modulating NF-κB signaling. These findings underscore its dual utility as a sweetener and therapeutic agent.

Industrial applications of Mogroside VI are expanding, with patents filed for its use in functional foods and nutraceuticals. A 2024 market analysis by Grand View Research projects a 12.3% CAGR for mogrosides in the global sweetener market, driven by demand for natural sugar alternatives. Challenges remain in scaling biosynthesis via microbial fermentation, though recent CRISPR-based engineering of Yarrowia lipolytica strains shows promise for cost-effective production.

In conclusion, Mogroside VI represents a multifaceted compound bridging food science and biomedicine. Ongoing clinical trials (e.g., NCT05678984 evaluating its anti-diabetic efficacy) may further validate its therapeutic potential. Future research should address bioavailability optimization and structure-activity relationships of derivatives to expand its applications.

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