Cas no 189064-06-0 (Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt)
Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt Chemical and Physical Properties
Names and Identifiers
-
- L-Phenylalaninamide,N2-acetyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl- (9CI)
- (2S)-2-acetamido-N-[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl
- Ac-Amyloid [beta]-Protein (15-20) amide
- Acetyl-Amyloid β -Protein (15-20) amide
- Acetyl-Amyloid
- AC-GLN-LYS-LEU-VAL-PHE-PHE- NH2
- Ac-QKLVFF-NH2
- Ac-QKLVFF-NH2,amyloid blocker
- amyloid blocker
- A-Protein Fragment 15-20 Amide
- AC-QKLVFF
- BETA-AMYLOID LIGAND
- ACETYL-BETA-AMYLOID (15-20)
- AC-GLN-LYS-LEU-VAL-PHE-PHE-OH
- Acetyl-Amyloid β-Protein (15-20)
- Ac-Amyloid β-Protein (15-20) amide
- AC-AMYLOID BETA-PROTEIN (15-20) AMIDE
- AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2
- CS-0900520
- DTXSID80746717
- N~2~-Acetyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalaninamide
- 189064-06-0
- A Amyloid(15-20), Amide
- HY-P5967
- Acetly-
- (2S)-2-acetamido-N-[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]pentanediamide
- Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt
-
- MDL： MFCD17215285
- Inchi： 1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1
- InChI Key： DDXTVYDSGCHGAN-PITCCTKHSA-N
- SMILES： O=C([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC(C)=O)=O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC1C=CC=CC=1)=O)CC1C=CC=CC=1)=O)C(C)C
Computed Properties
- Exact Mass: 822.46400
- Monoisotopic Mass: 821.47996000g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 9
- Hydrogen Bond Acceptor Count: 9
- Heavy Atom Count: 59
- Rotatable Bond Count: 26
- Complexity: 1400
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 6
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.8
- Topological Polar Surface Area: 287?2
Experimental Properties
- PSA: 281.01000
- LogP: 4.32770
Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt Security Information
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Storage Condition：?20°C
Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | A297970-10mg |
Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt |
189064-06-0 | 10mg |
$ 360.00 | 2022-06-08 | ||
| TRC | A297970-25mg |
Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt |
189064-06-0 | 25mg |
$ 745.00 | 2022-06-08 | ||
| TRC | A297970-50mg |
Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt |
189064-06-0 | 50mg |
$ 1185.00 | 2022-06-08 | ||
| AAPPTec | P001079-5mg |
Ac-Amyloid beta-Protein (15-20) amide |
189064-06-0 | 5mg |
$85.00 | 2024-07-20 | ||
| AAPPTec | P001079-10mg |
Ac-Amyloid beta-Protein (15-20) amide |
189064-06-0 | 10mg |
$140.00 | 2024-07-20 | ||
| AAPPTec | P001079-25mg |
Ac-Amyloid beta-Protein (15-20) amide |
189064-06-0 | 25mg |
$280.00 | 2024-07-20 | ||
| A2B Chem LLC | AE99189-5mg |
AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2 |
189064-06-0 | 5mg |
$200.00 | 2024-04-20 | ||
| A2B Chem LLC | AE99189-10mg |
AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2 |
189064-06-0 | 10mg |
$265.00 | 2024-04-20 | ||
| A2B Chem LLC | AE99189-25mg |
AC-GLN-LYS-LEU-VAL-PHE-PHE-NH2 |
189064-06-0 | 25mg |
$430.00 | 2024-04-20 |
Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt Related Literature
-
Pengfan Gao,Yuqing Wu,Lixin Wu Soft Matter 2016 12 8464
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Héctor Soria-Carrera,Elena Atrián-Blasco,Rafael Martín-Rapún,Scott G. Mitchell Chem. Sci. 2023 14 10
Additional information on Acetyl-Amyloid b-Protein (15-20) amide trifluoroacetate salt
Comprehensive Overview of Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt (CAS No. 189064-06-0)
Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt is a synthetic peptide derivative that has garnered significant attention in neuroscience and biochemical research. With the CAS number 189064-06-0, this compound is widely used in studies related to Alzheimer's disease, amyloid aggregation, and neurodegenerative disorders. Researchers are particularly interested in its role in mimicking the behavior of amyloid-beta peptides, which are key players in the pathogenesis of Alzheimer's.
The Acetyl-Amyloid β-Protein (15-20) amide sequence corresponds to a fragment of the larger amyloid-beta protein, specifically residues 15 to 20. The trifluoroacetate salt form enhances its solubility and stability, making it suitable for various experimental applications. This peptide is often utilized in in vitro assays, cell culture studies, and animal models to investigate mechanisms of amyloid plaque formation and potential therapeutic interventions.
One of the most pressing hot topics in biomedical research today is the search for effective treatments for Alzheimer's disease. Given the rising global prevalence of neurodegenerative conditions, compounds like Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt are critical tools for understanding disease mechanisms. Researchers frequently search for terms such as "amyloid-beta inhibitors", "Alzheimer's peptide models", and "neuroprotective compounds", highlighting the relevance of this peptide in contemporary studies.
From a structural perspective, the Acetyl-Amyloid β-Protein (15-20) amide fragment includes key amino acids that contribute to the aggregation propensity of amyloid-beta. The acetyl group at the N-terminus and the amide modification at the C-terminus further stabilize the peptide, ensuring consistent performance in experimental settings. The trifluoroacetate counterion aids in purification and handling, making this compound a reliable choice for high-throughput screening and detailed biochemical analyses.
In addition to its research applications, Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt is also valuable in drug discovery programs. Pharmaceutical companies and academic labs use this peptide to screen potential amyloid aggregation inhibitors or to validate the efficacy of novel therapeutic candidates. The growing interest in precision medicine and targeted therapies for neurodegenerative diseases underscores the importance of such specialized research reagents.
Another area of interest is the peptide's role in biomarker development. Scientists are exploring whether fragments like Acetyl-Amyloid β-Protein (15-20) amide can serve as early indicators of amyloid pathology in cerebrospinal fluid or blood samples. This aligns with the increasing demand for non-invasive diagnostic tools in Alzheimer's research and clinical trials.
Handling and storage of Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt require adherence to standard laboratory protocols. The peptide should be stored at -20°C in a dry environment to maintain stability. Researchers are advised to reconstitute the compound in appropriate buffers, such as phosphate-buffered saline (PBS) or dimethyl sulfoxide (DMSO), depending on the experimental requirements.
The market for research peptides, including Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt, has expanded significantly in recent years. This growth is driven by advancements in peptide synthesis technologies, increased funding for neurodegenerative disease research, and collaborations between academia and industry. As the scientific community continues to unravel the complexities of amyloid-beta toxicity, the demand for high-quality peptide reagents is expected to rise.
In summary, Acetyl-Amyloid β-Protein (15-20) amide trifluoroacetate salt (CAS No. 189064-06-0) is a vital tool for researchers investigating Alzheimer's disease and related neurodegenerative disorders. Its well-defined structure, stability, and relevance to current biomedical research trends make it an indispensable component of modern neuroscience studies. Whether used in basic research, drug development, or diagnostic applications, this peptide continues to contribute to our understanding of amyloid pathology and potential therapeutic strategies.
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