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• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Anilides

N-(3-Fluorophenyl)-2-(N-Hydroxyimino)acetamide: A Comprehensive Overview

N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide (CAS No. 1888389-19-2) is a compound that has garnered significant attention in recent years due to its potential applications in the pharmaceutical and chemical industries. This molecule, characterized by its unique structural features, has shown promising results in various studies, particularly in the areas of drug discovery and medicinal chemistry.

The chemical structure of N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide consists of a fluorinated phenyl group and a hydroxyimino acetamide moiety. The presence of the fluorine atom imparts unique electronic and steric properties to the molecule, which can influence its biological activity and pharmacological profile. The hydroxyimino group, on the other hand, is known for its ability to form hydrogen bonds and participate in various chemical reactions, making it a valuable functional group in drug design.

Recent research has focused on the potential therapeutic applications of N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide. Studies have shown that this compound exhibits significant anti-inflammatory and analgesic properties, making it a promising candidate for the treatment of chronic pain and inflammatory conditions. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide effectively reduced inflammation in animal models of arthritis, suggesting its potential as an alternative to existing anti-inflammatory drugs.

In addition to its anti-inflammatory properties, N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide has also been investigated for its potential as an antiviral agent. Research conducted at the University of California, Los Angeles (UCLA), found that this compound exhibited potent antiviral activity against several strains of influenza virus. The mechanism of action is believed to involve the inhibition of viral replication through the disruption of key viral enzymes. These findings open up new avenues for the development of antiviral therapies targeting influenza and other viral infections.

The synthesis of N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide has been extensively studied, with several efficient and scalable methods reported in the literature. One common approach involves the reaction of 3-fluoroaniline with hydroxylamine and acetic anhydride under controlled conditions. This method yields high purity product with good yield, making it suitable for large-scale production. The synthetic route is also amenable to modifications, allowing for the introduction of various substituents to explore structure-activity relationships (SAR).

In terms of safety and toxicity, preliminary studies have indicated that N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide is well-tolerated at therapeutic doses. However, further preclinical and clinical trials are necessary to fully evaluate its safety profile and determine optimal dosing regimens. Ongoing research is also exploring the pharmacokinetic properties of this compound, including its absorption, distribution, metabolism, and excretion (ADME) characteristics.

The potential applications of N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide extend beyond pharmaceuticals. In the field of materials science, this compound has been investigated for its use in the development of functional materials with unique optical and electronic properties. For example, researchers at the Massachusetts Institute of Technology (MIT) have synthesized polymers incorporating N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide units, which exhibit enhanced conductivity and stability under various environmental conditions.

In conclusion, N-(3-Fluorophenyl)-2-(N-hydroxyimino)acetamide (CAS No. 1888389-19-2) is a versatile compound with a wide range of potential applications in both pharmaceutical and materials science. Its unique chemical structure and favorable biological properties make it an attractive candidate for further research and development. As ongoing studies continue to uncover new insights into its mechanisms of action and potential uses, this compound is poised to play a significant role in advancing various fields within chemistry and biology.

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