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  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
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  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
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  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
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  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
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Recent Advances in the Study of Coenzyme A,S-(9Z)-9-octadecenoate, monolithium salt (9CI) and Its Implications in Chemical Biology and Medicine

The compound with CAS number 188824-37-5, known as Coenzyme A,S-(9Z)-9-octadecenoate, monolithium salt (9CI), has recently garnered significant attention in the field of chemical biology and medicinal research. This molecule, a derivative of coenzyme A (CoA) conjugated with oleic acid, plays a crucial role in lipid metabolism and cellular signaling pathways. Recent studies have explored its potential applications in metabolic disorders, cancer therapy, and neurodegenerative diseases, making it a focal point for interdisciplinary research.

One of the key findings in recent literature is the role of Coenzyme A,S-(9Z)-9-octadecenoate in modulating fatty acid oxidation and energy homeostasis. A 2023 study published in the Journal of Biological Chemistry demonstrated that this compound enhances mitochondrial function by promoting the β-oxidation of fatty acids, thereby offering a potential therapeutic avenue for metabolic syndromes such as obesity and type 2 diabetes. The study utilized advanced mass spectrometry techniques to track the metabolic fate of the compound in murine models, revealing its rapid incorporation into cellular lipid pools.

In the context of cancer research, Coenzyme A,S-(9Z)-9-octadecenoate has shown promise as a modulator of tumor cell metabolism. A recent preprint from BioRxiv highlighted its ability to inhibit the Warburg effect—a hallmark of cancer cell metabolism???by redirecting energy production towards oxidative phosphorylation. This effect was particularly pronounced in triple-negative breast cancer cells, where the compound induced apoptosis and reduced tumor growth in xenograft models. These findings suggest its potential as an adjunct therapy in combination with existing chemotherapeutic agents.

Another groundbreaking study, published in Nature Chemical Biology in early 2024, explored the neuroprotective effects of Coenzyme A,S-(9Z)-9-octadecenoate. Researchers found that the compound mitigates oxidative stress in neuronal cells by upregulating endogenous antioxidant defenses, such as glutathione peroxidase. This property was leveraged in a mouse model of Parkinson’s disease, where administration of the compound significantly improved motor function and reduced dopaminergic neuron loss. The study also identified the monolithium salt form as particularly bioavailable, enhancing its therapeutic potential.

From a synthetic chemistry perspective, advancements in the scalable production of Coenzyme A,S-(9Z)-9-octadecenoate, monolithium salt (9CI) have been reported. A 2023 paper in Organic Process Research & Development detailed a novel enzymatic synthesis route that improves yield and purity while reducing environmental impact. This method employs immobilized acyl-CoA synthetase, enabling continuous production and easier downstream purification. Such innovations are critical for facilitating further preclinical and clinical studies.

In summary, the latest research on Coenzyme A,S-(9Z)-9-octadecenoate, monolithium salt (9CI) underscores its multifaceted roles in metabolism, oncology, and neuroprotection. Its unique chemical properties and biological activities position it as a promising candidate for therapeutic development. Future studies should focus on elucidating its pharmacokinetics and pharmacodynamics in humans, as well as exploring its interactions with other biomolecules in diverse pathological contexts.

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• 1264-52-4(Octanoyl Coenzyme A)
• 1763-10-6(Coenzyme A, S-hexadecanoate)
• 1716-06-9(Coenzyme A, S-(9Z)-9-octadecenoate)
• 187100-75-0(Coenzyme A,S-tetradecanoate, lithium salt (9CI))
• 108347-97-3(Succinyl Coenzyme A Sodium)
• 85-61-0(Coenzyme A)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
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• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)