Cas no 188723-58-2 ((5-Chloro-2-fluorophenyl)methanol)

(5-Chloro-2-fluorophenyl)methanol is a fluorinated and chlorinated aromatic alcohol with the molecular formula C?H?ClFO. This compound serves as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. Its distinct substitution pattern—featuring both chloro and fluoro groups—enhances reactivity and selectivity in cross-coupling and derivatization reactions. The hydroxyl group allows for further functionalization, enabling the synthesis of esters, ethers, or other derivatives. The compound exhibits high purity and stability under standard storage conditions, making it suitable for precision applications. Its structural features contribute to its utility in designing bioactive molecules with tailored properties.
(5-Chloro-2-fluorophenyl)methanol structure
188723-58-2 structure
Product Name:(5-Chloro-2-fluorophenyl)methanol
CAS No:188723-58-2
MF:C7H6ClFO
MW:160.573344707489
MDL:MFCD01631436
CID:139276
PubChem ID:2773613
Update Time:2025-10-21

(5-Chloro-2-fluorophenyl)methanol Chemical and Physical Properties

Names and Identifiers

    • (5-Chloro-2-fluorophenyl)methanol
    • 5-chloro-2-fluoro-Benzenemethanol
    • 5-CHLORO-2-FLUOROBENZYL ALCOHOL
    • Benzenemethanol,5-chloro-2-fluoro-
    • RARECHEM AL BD 1329
    • 5-Chloro-2-fluorobenzylalcohol97%
    • DTXSID00378594
    • 188723-58-2
    • SCHEMBL92920
    • CK2452
    • 5-chloro-2-fluorobenzyl alcohol, AldrichCPR
    • PS-8775
    • EN300-1984992
    • Benzenemethanol, 5-chloro-2-fluoro-
    • AKOS009158380
    • 2-fluoro-5-chlorobenzyl alcohol
    • MFCD01631436
    • CS-0207066
    • GTHWNKHWLSRSNW-UHFFFAOYSA-N
    • 5-chloro-2-fluorobenzylalcohol
    • SY063145
    • MDL: MFCD01631436
    • Inchi: 1S/C7H6ClFO/c8-6-1-2-7(9)5(3-6)4-10/h1-3,10H,4H2
    • InChI Key: GTHWNKHWLSRSNW-UHFFFAOYSA-N
    • SMILES: ClC1=CC=C(C(=C1)CO)F

Computed Properties

  • Exact Mass: 160.00900
  • Monoisotopic Mass: 160.009
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1
  • Complexity: 110
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.3
  • Topological Polar Surface Area: 20.2A^2

Experimental Properties

  • Density: 1.344
  • Boiling Point: 233 oC
  • Flash Point: 95 oC
  • Refractive Index: 1.542
  • PSA: 20.23000
  • LogP: 1.97140

(5-Chloro-2-fluorophenyl)methanol Customs Data

  • HS CODE:2906299090
  • Customs Data:

    China Customs Code:

    2906299090

    Overview:

    2906299090 Other aromatic alcohols. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2906299090 other aromatic alcohols.Supervision conditions:None.VAT:17.0%.Tax rebate rate:9.0%.MFN tariff:5.5%.General tariff:30.0%

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Additional information on (5-Chloro-2-fluorophenyl)methanol

Comprehensive Overview of (5-Chloro-2-fluorophenyl)methanol (CAS No. 188723-58-2): Properties, Applications, and Industry Insights

(5-Chloro-2-fluorophenyl)methanol (CAS No. 188723-58-2) is a fluorinated aromatic alcohol with significant relevance in pharmaceutical and agrochemical research. This compound, characterized by its chloro-fluorophenyl backbone, serves as a versatile intermediate in synthetic chemistry. Its molecular structure, featuring both halogen substituents and a hydroxyl group, enables diverse functionalization, making it a focal point for drug discovery and material science applications.

Recent trends highlight growing interest in fluorinated building blocks like (5-Chloro-2-fluorophenyl)methanol, driven by their enhanced metabolic stability and bioavailability in drug design. Searches for "fluorophenyl derivatives in medicinal chemistry" or "CAS 188723-58-2 suppliers" reflect industry demand. The compound’s role in synthesizing kinase inhibitors and antiviral agents aligns with current research on targeted therapies, addressing queries such as "how to optimize halogenated intermediates" in peer-reviewed forums.

From a technical perspective, 188723-58-2 exhibits a melting point range of 80–85°C and solubility in polar organic solvents, critical for reaction scalability. Analytical techniques like HPLC and NMR confirm its high purity (>98%), a key concern for users searching "quality control for fluorinated intermediates." Environmental and regulatory compliance—often queried as "green synthesis of halogenated alcohols"—is addressed through solvent-free protocols, reducing waste generation.

Innovative applications of (5-Chloro-2-fluorophenyl)methanol extend to liquid crystal materials and OLED precursors, resonating with searches for "halogenated aromatics in electronics." Its stability under mild conditions also supports catalytic asymmetric synthesis, a hotspot in academic publications. Suppliers emphasizing "custom synthesis of CAS 188723-58-2" cater to niche markets, while patents highlight its utility in proteolysis-targeting chimeras (PROTACs).

In conclusion, 188723-58-2 exemplifies the intersection of structural modularity and industrial utility. As demand for tailor-made fluorophores and bioactive scaffolds grows, this compound remains pivotal—answering FAQs like "safety handling of fluorophenyl alcohols" with documented protocols. Its adaptability ensures sustained relevance across R&D sectors, from small-molecule APIs to advanced materials.

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