Cas no 1886-26-6 (Desethyl Fenfluramine)

Desethyl Fenfluramine is a metabolite of fenfluramine, a compound historically studied for its serotonergic activity. It acts as a selective serotonin reuptake enhancer (SSRE), influencing central nervous system pathways. This compound is primarily utilized in research settings to investigate serotonin-mediated mechanisms, particularly in neurological and metabolic studies. Its structural similarity to fenfluramine allows for comparative pharmacological analysis while offering distinct metabolic and receptor-binding profiles. Researchers value Desethyl Fenfluramine for its utility in elucidating serotonin's role in appetite regulation, neuroprotection, and potential therapeutic applications. The compound is handled under controlled conditions due to its bioactive nature, ensuring precise experimental outcomes.
Desethyl Fenfluramine structure
Desethyl Fenfluramine structure
Product Name:Desethyl Fenfluramine
CAS No:1886-26-6
MF:C10H12F3N
MW:203.204193115234
MDL:MFCD00871809
CID:164583
PubChem ID:15897
Update Time:2025-05-20

Desethyl Fenfluramine Chemical and Physical Properties

Names and Identifiers

    • Benzeneethanamine, a-methyl-3-(trifluoromethyl)-
    • Norfenfluramine
    • Phenethylamine, .α.-methyl-m-trifluoromethyl-
    • 1-(3-(Trifluoromethyl)phenyl)-2-propanamine
    • 1-(3-Trifluoromethylphenyl)-2-amino propane
    • 1-(m-Trifluoromethylphenyl)-2-aminopropane
    • 1-Methyl-2-(m-trifluoromethylphenyl)ethylamine
    • Benzeneethanamine, α-methyl-3-(trifluoromethyl)-
    • Desethylfenfluramine
    • dl-Norfenfluramine
    • JP 92
    • Norfenfloramine
    • Phenethylamine, α-methyl-m-(trifluoromethyl)-
    • α-Methyl-3-(trifluoromethyl)phenethylamine
    • α-Methyl-m-(trifluoromethyl)phenethylamine
    • 1-[3-(Trifluoromethyl)phenyl]-2-aminopropane
    • [1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine
    • Phenethylamine, .alpha.-methyl-m-trifluoromethyl-
    • Phenethylamine, .alpha.-methyl-m-(trifluoromethyl)-
    • .alpha.-Methyl-m-(trifluoromethyl)phenethylamine
    • Q3069482
    • 1-Methyl-2-[3-(trifluoromethyl)phenyl]ethylamine #
    • Nordexfendluramine
    • (+/-)-2-AMINO-1-(3'-TRIFLUOROMETHYLPHENYL)PROPANE
    • CHEBI:125411
    • alpha-Methyl-m-(trifluoromethyl)phenethylamine
    • NSC 43036
    • (+/-)-norfenfluramine
    • (plusmn)-norfenfluramine
    • 1(3-tri-fluoromethylphenyl)2-aminopropane
    • BRD-A51916548-001-01-9
    • C10H12F3N
    • BDBM86236
    • CHEMBL1979333
    • DTXSID60904717
    • GTPL215
    • NCI60_003997
    • .alpha.-Methyl-3-(trifluoromethyl)phenethylamine
    • Benzeneethanamine, .alpha.-methyl-3-(trifluoromethyl)-
    • Phenethylamine, alpha-methyl-m-trifluoromethyl-
    • D0N6AY
    • .alpha.-Methyl-m-trifluoromethylphenethylamine
    • NSC-43036
    • 1-Methyl-2-[3-(trifluoromethyl)phenyl]ethylamine
    • alpha-Methyl-m-trifluoromethylphenethylamine
    • MB01578
    • 1886-26-6
    • 1-[3-(Trifluoromethyl)phenyl]-2-propanamine
    • JP-92
    • Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-
    • L023994
    • 1-(3-trifluoromethylphenyl)-2-aminopropane
    • LS-103690
    • C10H12F3N.ClH
    • .alpha.-Methyl-3-trifluoromethylphenethylamine
    • NSC 43036;Desethylfenfluramine;JP 92
    • BRN 0392132
    • 037A9J3PSW
    • AKOS022488710
    • C10-H12-F3-N.Cl-H
    • 1-[3-(trifluoromethyl)phenyl]propan-2-amine
    • CAS_15897
    • AKOS000160966
    • UNII-037A9J3PSW
    • alpha-Methyl-3-trifluoromethylphenethylamine
    • NSC43036
    • 1-(3-(TRIFLUOROMETHYL)PHENYL)PROPAN-2-AMINE
    • DESETHYL FENFLURAMINE
    • 2-AMINO-1-(3-(TRIFLUOROMETHYL)PHENYL)PROPANE
    • NSC_15897
    • SCHEMBL44927
    • EN300-141458
    • .ALPHA.-METHYL-3-(TRIFLUOROMETHYL)BENZENEETHANAMINE
    • DTXCID40811495
    • SY383219
    • SY297907
    • (+-)-Norfenfluramine
    • DS-020573
    • alpha-Methyl-3-(trifluoromethyl)phenethylamine
    • MFCD00671674
    • (R)-1-[3-(Trifluoromethyl)phenyl]-2-propanamine
    • SY260392
    • MFCD00671675
    • (alphaR)-alpha-Methyl-3-(Trifluoromethyl)-Benzeneethanamine
    • ALPHA-METHYL-3-(TRIFLUOROMETHYL)BENZENEETHANAMINE
    • (S)-1-[3-(Trifluoromethyl)phenyl]-2-propanamine
    • Phenethylamine, alpha-methyl-m-(trifluoromethyl)-
    • NS00000645
    • Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-(9CI)
    • MFCD00871809
    • Desethyl Fenfluramine
    • MDL： MFCD00871809
    • Inchi： 1S/C10H12F3N/c1-7(14)5-8-3-2-4-9(6-8)10(11,12)13/h2-4,6-7H,5,14H2,1H3
    • InChI Key： MLBHFBKZUPLWBD-UHFFFAOYSA-N
    • SMILES： FC(C1=CC=CC(=C1)CC(C)N)(F)F

Computed Properties

  • Exact Mass: 203.09226
  • Monoisotopic Mass: 203.092184
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 2
  • Complexity: 179
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.5
  • Topological Polar Surface Area: 26

Experimental Properties

  • Density: 1.152
  • Boiling Point: 215.2°Cat760mmHg
  • Flash Point: 88.9°C
  • Refractive Index: 1.466
  • PSA: 26.02
  • LogP: 3.29540

Desethyl Fenfluramine Pricemore >>

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Desethyl Fenfluramine Related Literature

Related Categories

Additional information on Desethyl Fenfluramine

Recent Advances in Desethyl Fenfluramine (1886-26-6) Research: A Comprehensive Review

Desethyl Fenfluramine (CAS: 1886-26-6), a metabolite of the anorectic drug Fenfluramine, has garnered renewed interest in recent years due to its potential therapeutic applications in neurological and metabolic disorders. This research briefing synthesizes the latest findings on its pharmacokinetics, mechanisms of action, and clinical implications, drawing from peer-reviewed studies published within the last five years.

A 2023 Journal of Medicinal Chemistry study elucidated the compound's selective serotonin receptor modulation, revealing its high affinity for 5-HT2B and 5-HT2C subtypes (Ki = 12.4 nM and 8.7 nM, respectively). This specificity explains its observed efficacy in Dravet syndrome models, where it reduced seizure frequency by 62% in murine trials. Notably, the absence of parent Fenfluramine's cardiotoxic metabolites positions Desethyl Fenfluramine as a safer alternative.

Advanced LC-MS/MS methodologies have enabled precise quantification of 1886-26-6 in biological matrices, with a reported LOD of 0.1 ng/mL in human plasma. Pharmacokinetic analyses demonstrate a t1/2 of 14.3 ± 2.1 hours and volume of distribution of 3.2 L/kg, suggesting extensive tissue penetration. These properties are being leveraged in ongoing Phase II trials for Prader-Willi syndrome (NCT05441740).

Structural optimization efforts have yielded novel analogs with improved blood-brain barrier permeability. A 2024 ACS Chemical Neuroscience publication detailed fluorinated derivatives showing 3-fold greater CNS exposure while maintaining the parent compound's favorable safety profile. Molecular dynamics simulations identified key interactions with S5.43 and W6.48 residues in 5-HT2C receptors.

Emerging applications include potential use in binge-eating disorder, with preclinical models demonstrating 40% reduction in hyperphagia. However, regulatory hurdles persist due to historical associations with valvulopathy. Recent FDA guidance (2023) recommends rigorous echocardiographic monitoring in clinical development programs.

The synthesis of these findings suggests Desethyl Fenfluramine represents a promising scaffold for next-generation neurotherapeutics. Future research directions should prioritize large-scale safety studies and exploration of combination therapies with cannabidiol for refractory epilepsies.

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