• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 2. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 3. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 4. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 5. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119

Recent Advances in the Application of 4-[(Tert-butyldimethylsilyl)oxy]-2,6-difluorophenol (CAS: 1881327-86-1) in Chemical Biology and Pharmaceutical Research

The compound 4-[(Tert-butyldimethylsilyl)oxy]-2,6-difluorophenol (CAS: 1881327-86-1) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its unique structural properties and versatile applications. This phenol derivative, protected by a tert-butyldimethylsilyl (TBS) group, serves as a key intermediate in the synthesis of various biologically active molecules, including fluorinated pharmaceuticals and agrochemicals. Recent studies have highlighted its role in facilitating selective reactions, enhancing compound stability, and enabling the development of novel therapeutic agents.

One of the most notable applications of 4-[(Tert-butyldimethylsilyl)oxy]-2,6-difluorophenol is its use in the synthesis of fluorinated aromatic compounds, which are increasingly important in drug discovery. Fluorination often improves the pharmacokinetic properties of drug candidates, such as metabolic stability and membrane permeability. Researchers have successfully employed this compound in palladium-catalyzed cross-coupling reactions to construct complex fluorinated scaffolds, which are prevalent in many FDA-approved drugs. The TBS-protecting group ensures the stability of the phenol moiety during these transformations, allowing for high-yield and regioselective reactions.

In addition to its synthetic utility, 4-[(Tert-butyldimethylsilyl)oxy]-2,6-difluorophenol has been investigated for its potential as a building block in the development of enzyme inhibitors. Recent studies have demonstrated its incorporation into inhibitors targeting tyrosine kinases and other key enzymes involved in cancer progression. The difluorophenol moiety, in particular, has been shown to enhance binding affinity and selectivity, making it a valuable structural motif in medicinal chemistry. Furthermore, the TBS group can be selectively removed under mild conditions, enabling further functionalization of the inhibitor scaffold.

Another emerging area of research involves the use of this compound in the design of prodrugs. Prodrug strategies are widely employed to improve the bioavailability and delivery of active pharmaceutical ingredients. The TBS-protected phenol can serve as a masked hydroxyl group, which can be enzymatically or chemically cleaved in vivo to release the active drug. Recent preclinical studies have reported promising results with prodrugs derived from 4-[(Tert-butyldimethylsilyl)oxy]-2,6-difluorophenol, particularly in the context of targeted therapies for inflammatory diseases and central nervous system disorders.

Despite its promising applications, challenges remain in the large-scale synthesis and purification of 4-[(Tert-butyldimethylsilyl)oxy]-2,6-difluorophenol. Recent advancements in flow chemistry and continuous manufacturing have shown potential in addressing these issues, offering more efficient and scalable production methods. Additionally, researchers are exploring greener alternatives to traditional silylation reagents to reduce the environmental impact of its synthesis.

In conclusion, 4-[(Tert-butyldimethylsilyl)oxy]-2,6-difluorophenol (CAS: 1881327-86-1) represents a versatile and valuable tool in modern chemical biology and pharmaceutical research. Its applications span from synthetic chemistry to drug development, highlighting its importance in the discovery of next-generation therapeutics. Ongoing research efforts are expected to further expand its utility and optimize its production, solidifying its role in the advancement of the field.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)