• 1. 167. Synthetic antimalarials. Part XVII. Some aminoalkylaminoquinoline derivatives
  F. H. S. Curd,C. G. Raison,F. L. Rose J. Chem. Soc. 1947 899
• 2. 269. Cyanine dyes derived from 2-methylindolo(3′ : 2′-3 : 4)quinoline
  Frederick G. Mann,A. F. Prior J. Chem. Soc. 1956 1331
• 3. Quinolines and uracils from reactions of isocyanates with aliphatic aldehydes
  Iwao Yamamoto,Takeshi Furukawa,Hiroshi Nakajima,Haruo Gotoh J. Chem. Soc. Perkin Trans. 1 1976 1597
• 4. Organic chemistry
  J. Chem. Soc. Abstr. 1898 74 A613
• 5. Reaction behaviour of arylamines with nitroalkenes in the presence of bismuth(iii) triflate: an easy access to 2,3-dialkylquinolines
  Saghir Ali,Radhakrishna Gattu,Varun Singh,Santa Mondal,Abu T. Khan,Gurudutt Dubey,P. V. Bharatam Org. Biomol. Chem. 2020 18 1785

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinolines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives

Research Brief on 3-Ethylquinoline (CAS: 1873-54-7) in Chemical Biology and Pharmaceutical Applications

3-Ethylquinoline (CAS: 1873-54-7) is a heterocyclic organic compound that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This research brief synthesizes the latest findings on the synthesis, biological activity, and potential therapeutic applications of 3-Ethylquinoline, providing a comprehensive overview for professionals in the field.

Recent studies have highlighted the role of 3-Ethylquinoline as a key intermediate in the synthesis of bioactive molecules. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in the development of novel kinase inhibitors, showcasing its potential in targeting cancer-related pathways. The compound's unique structural features, including its quinoline core and ethyl substitution, contribute to its ability to modulate protein-protein interactions and enzyme activity.

In addition to its role in drug discovery, 3-Ethylquinoline has been investigated for its antimicrobial properties. A 2022 study in Bioorganic & Medicinal Chemistry Letters reported that derivatives of 3-Ethylquinoline exhibited potent activity against multidrug-resistant bacterial strains, suggesting its potential as a scaffold for developing new antibiotics. The study also emphasized the importance of the ethyl group in enhancing the compound's bioavailability and target specificity.

Advancements in synthetic methodologies have further expanded the applications of 3-Ethylquinoline. A recent publication in Organic Letters (2023) described a novel catalytic system for the efficient synthesis of 3-Ethylquinoline derivatives, enabling the exploration of its chemical space with greater precision. This breakthrough is expected to accelerate the discovery of new lead compounds in drug development.

Despite these promising developments, challenges remain in optimizing the pharmacokinetic and safety profiles of 3-Ethylquinoline-based therapeutics. Ongoing research aims to address these limitations through structural modifications and formulation strategies. Future directions include the integration of computational modeling and high-throughput screening to identify optimal derivatives for specific therapeutic targets.

In conclusion, 3-Ethylquinoline (CAS: 1873-54-7) represents a valuable scaffold in chemical biology and pharmaceutical research, with demonstrated potential in drug discovery and antimicrobial applications. Continued exploration of its chemical and biological properties is likely to yield innovative therapeutic agents, underscoring its importance in the field.

• 107921-93-7(1,10-Phenanthroline, 3-ethyl-)
• 116529-83-0(Quinoline, 3-ethyl-7-methyl-)
• 89836-49-7(Quinoline, 6-methyl-3-(phenylmethyl)-)
• 89816-39-7(Quinoline, 6-methyl-3-[(4-methylphenyl)methyl]-)
• 6457-30-3(8-(propan-2-yl)quinoline)
• 105688-74-2(Quinoline, 3-ethyl-6-methyl-)
• 37045-16-2(Quinoline,3-(phenylmethyl)-)
• 20668-43-3(Quinoline, 3-propyl-)
• 19655-56-2(8-Ethylquinoline)
• 17692-04-5(Quinoline, 3-pentyl-)