• 1. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 2. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
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• 3. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells?
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• 4. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines
• Solvents and Organic Chemicals Organic Compounds Organic Halides

2-Chloro-3-nitro-6-phenylpyridine: A Versatile Chemical Compound for Modern Applications

2-Chloro-3-nitro-6-phenylpyridine (CAS No. 187242-88-2) is a specialized heterocyclic organic compound that has garnered significant attention in chemical research and industrial applications due to its unique structural properties. This compound, often referred to by its systematic name or abbreviated as 2-chloro-3-nitro-6-phenylpyridine, features a pyridine ring substituted with chloro, nitro, and phenyl groups at specific positions, making it a valuable intermediate in synthetic chemistry. Its molecular formula is C11H7ClN2O2, and it exhibits a molecular weight of approximately 234.64 g/mol. The presence of electron-withdrawing groups like nitro and chloro enhances its reactivity, facilitating its use in various cross-coupling reactions and as a building block for more complex molecules. Researchers and industries are increasingly exploring this compound for its potential in developing novel materials and bioactive agents, aligning with current trends in sustainable chemistry and green synthesis.

The chemical properties of 2-Chloro-3-nitro-6-phenylpyridine make it a subject of interest in organic synthesis and material science. Its nitro group acts as a strong electron acceptor, while the chloro group serves as a good leaving group, enabling nucleophilic substitution reactions that are crucial for constructing heterocyclic frameworks. This compound is typically a solid at room temperature, with a melting point ranging between 120-125°C, and it demonstrates moderate solubility in polar organic solvents such as dimethyl sulfoxide (DMSO) and acetonitrile. These characteristics are essential for its handling in laboratory settings and industrial processes, where precise control over reaction conditions is required. Moreover, its stability under various pH conditions allows for versatile applications, from catalysis to polymer chemistry, addressing the growing demand for efficient and environmentally friendly chemical processes. Users often search for terms like "properties of 2-chloro-3-nitro-6-phenylpyridine" or "chemical reactivity of nitro-substituted pyridines" to understand its behavior in synthetic pathways, highlighting its relevance in advanced research.

In terms of applications, 2-Chloro-3-nitro-6-phenylpyridine is widely utilized as a key intermediate in the pharmaceutical and agrochemical industries. It serves as a precursor for synthesizing various derivatives that exhibit biological activities, such as antimicrobial and anti-inflammatory agents. For instance, modifications of this compound can lead to the development of new drugs targeting specific enzymes or receptors, contributing to the fight against antibiotic resistance—a hot topic in healthcare. Additionally, in material science, it is employed in the creation of organic light-emitting diodes (OLEDs) and conductive polymers, which are pivotal for next-generation electronic devices. Searches like "applications of 2-chloro-3-nitro-6-phenylpyridine in medicine" or "use in OLED technology" reflect user interest in its practical benefits. The compound's role in green chemistry initiatives, such as catalyzing reactions with reduced waste, also aligns with global sustainability goals, making it a focal point for innovations in eco-friendly manufacturing.

The synthesis of 2-Chloro-3-nitro-6-phenylpyridine typically involves multi-step organic reactions, starting from simpler pyridine derivatives. Common methods include chlorination and nitration of 6-phenylpyridine under controlled conditions to achieve high yield and purity. Recent advancements have focused on optimizing these processes using microwave-assisted synthesis or flow chemistry to enhance efficiency and reduce environmental impact. This ties into broader discussions on "green synthesis methods for heterocyclic compounds," a trending topic as industries seek to minimize carbon footprints. Quality control measures, such as HPLC and NMR spectroscopy, ensure the compound meets stringent standards for research and commercial use. Its compatibility with automated synthesis platforms further supports its integration into high-throughput screening for drug discovery, addressing queries like "how to synthesize 2-chloro-3-nitro-6-phenylpyridine efficiently" often seen in academic and industrial forums.

Market dynamics for 2-Chloro-3-nitro-6-phenylpyridine indicate a steady growth trajectory, driven by increasing demand from the pharmaceutical and electronics sectors. According to industry reports, the global market for specialized chemical intermediates is expected to expand at a compound annual growth rate (CAGR) of around 5-7% over the next decade, with compounds like this playing a crucial role. Factors such as rising investments in R&D for new therapeutics and the expansion of renewable energy technologies contribute to this trend. Users frequently search for "market trends for nitro-pyridine derivatives" or "suppliers of 2-chloro-3-nitro-6-phenylpyridine" to stay informed about availability and pricing. Major manufacturers are focusing on scalable production techniques and regulatory compliance to meet global standards, ensuring safe and reliable supply chains. This compound's versatility also makes it a candidate for emerging fields like nanotechnology and biosensors, further fueling its commercial appeal.

Handling and storage of 2-Chloro-3-nitro-6-phenylpyridine require adherence to standard laboratory safety protocols to ensure stability and prevent degradation. It should be stored in a cool, dry place away from direct sunlight and moisture, typically in sealed containers under inert atmosphere conditions. Proper personal protective equipment (PPE), such as gloves and goggles, is recommended during manipulation to avoid skin or eye contact. While not classified under hazardous categories, it is essential to follow guidelines from organizations like OSHA or REACH for safe usage. This aspect connects to common user queries such as "safe handling of chemical intermediates" or "storage conditions for nitro compounds," emphasizing the importance of best practices in chemical management. Additionally, disposal should align with local regulations to minimize environmental impact, supporting broader efforts in responsible chemical stewardship.

In conclusion, 2-Chloro-3-nitro-6-phenylpyridine (CAS No. 187242-88-2) is a multifaceted compound with significant implications across various industries. Its unique chemical structure and reactivity profile make it invaluable for synthetic applications, particularly in pharmaceuticals and materials science. As research continues to uncover new potentials, this compound remains at the forefront of innovation, addressing contemporary challenges like sustainability and technological advancement. For those interested in deeper exploration, resources on "advanced uses of 2-chloro-3-nitro-6-phenylpyridine" or "future prospects in chemical research" provide further insights. Overall, its role exemplifies the intersection of chemistry and modern technology, offering promising avenues for future developments.

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