Cas no 186901-48-4 (Cortistatin-14)

Cortistatin-14 is a neuropeptide structurally related to somatostatin, consisting of 14 amino acids. It exhibits high affinity for somatostatin receptors (SSTRs), particularly SSTR1, SSTR2, and SSTR3, and displays unique biological activities distinct from somatostatin. Research indicates its potential role in modulating neuronal activity, immune responses, and inflammatory processes. Cortistatin-14 is noted for its ability to cross the blood-brain barrier, making it valuable for neurobiological studies. Its synthetic form is widely used in pharmacological and physiological research to investigate its regulatory effects on neurotransmission, sleep, and immune function. The peptide is characterized by high purity and stability, ensuring reliable experimental reproducibility.
Cortistatin-14 structure
Cortistatin-14 structure
Product Name:Cortistatin-14
CAS No:186901-48-4
MF:C81H113N19O19S2
MW:1721.00983595848
MDL:MFCD01075120
CID:138232
PubChem ID:329775102
Update Time:2025-05-23

Cortistatin-14 Chemical and Physical Properties

Names and Identifiers

    • (D-BPA13,TYR19)-MELANIN-CONCENTRATING HORMONE (HUMAN, MOUSE, RAT)
    • Cortistatin 14
    • Cortistatin-14
    • Cortistatin-14 (mouse, rat)
    • Cortistatin-14 (mouse, rat) (Des-Ala1,Pro2,Ser12)-Somatostatin-14-Lys
    • L-Lysinamide,L-prolyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-trypto...
    • L-Lysinamide,L-prolyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-pheny
    • PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS(DISULFIDE BRIDGE:CYS2-CYS13)
    • PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS: PCKNFFWKTFSSCKDISULFIDE BRIDGE CYS2-CYS13
    • CST-14
    • Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys [Disulfide bridge: 2–13]
    • 2-L-Proline-14a-L-lysinamide-2-14-somatostatin (Petromyzon marinus)
    • CST-14 (RAT)
    • CORTISTATIN (RAT)
    • CORTISTATIN (16-29)
    • Cortistatin14,Cortista
    • M.W. 1721.04 C81H113N19O19S2
    • (DES-ALA1,PRO2,SER12)-SOMATOSTATIN-14-LYS
    • 13)-disulfide
    • cortistatin14
    • BDBM85324
    • Cortistatin-14, >=97% (HPLC)
    • NCGC00167271-01
    • CS-0029008
    • CHEMBL5192321
    • PUBCHEM_16133803
    • CAS_186901-48-4
    • 186901-48-4
    • HY-P1212
    • AKOS024457590
    • cortistatin
    • DTXSID00583202
    • 193829-96-8
    • Corticostatin-14
    • Cortistatin 14, human, rat
    • Cortistatin-14 (trifluoroacetate salt)
    • AS-79557
    • L000204
    • 6-amino-2-[[19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-16-(1-hydroxyethyl)-7,10-bis(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-37-(pyrrolidine-2-carbonylamino)-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carbonyl]amino]hexanoic acid
    • MDL: MFCD01075120
    • Inchi: 1S/C81H113N19O19S2/c1-46(103)67-80(117)95-59(38-49-24-9-4-10-25-49)73(110)96-62(42-101)76(113)97-63(43-102)77(114)99-65(79(116)90-56(81(118)119)30-15-18-34-84)45-121-120-44-64(98-68(105)53-31-19-35-86-53)78(115)89-54(28-13-16-32-82)69(106)94-61(40-66(85)104)75(112)92-57(36-47-20-5-2-6-21-47)71(108)91-58(37-48-22-7-3-8-23-48)72(109)93-60(39-50-41-87-52-27-12-11-26-51(50)52)74(111)88-55(70(107)100-67)29-14-17-33-83/h2-12,20-27,41,46,53-65,67,86-87,101-103H,13-19,28-40,42-45,82-84H2,1H3,(H2,85,104)(H,88,111)(H,89,115)(H,90,116)(H,91,108)(H,92,112)(H,93,109)(H,94,106)(H,95,117)(H,96,110)(H,97,113)(H,98,105)(H,99,114)(H,100,107)(H,118,119)/t46-,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,67+/m1/s1
    • InChI Key: DDRPLNQJNRBRNY-WYYADCIBSA-N
    • SMILES: S1C[C@@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CC2C=CC=CC=2)C(N[C@@H](CC2C=CC=CC=2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(=O)O)CCCCN)=O)CS1)=O)=O)=O)CC1C=CC=CC=1)=O)[C@@H](C)O)=O)CCCCN)=O)CC1=CNC2C=CC=CC1=2)=O)=O)=O)=O)CCCCN)=O)NC([C@@H]1CCCN1)=O

Computed Properties

  • Exact Mass: 1719.79000
  • Monoisotopic Mass: 1719.79015480g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 23
  • Hydrogen Bond Acceptor Count: 25
  • Heavy Atom Count: 121
  • Rotatable Bond Count: 30
  • Complexity: 3400
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 15
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 1000
  • XLogP3: -2.7
  • Topological Polar Surface Area: 676?2

Experimental Properties

  • Color/Form: No data available
  • Density: 1.41±0.1 g/cm3 (20 oC 760 Torr),
  • Melting Point: No data available
  • Boiling Point: 1999.9±65.0 °C at 760 mmHg
  • Flash Point: 1163.3±34.3 °C
  • Solubility: Soluble (170 g/l) (25 o C),
  • PSA: 675.86000
  • LogP: 3.12890

Cortistatin-14 Pricemore >>

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Cortistatin-14 Related Literature

Additional information on Cortistatin-14

Cortistatin-14: A Comprehensive Overview

Cortistatin-14, identified by the CAS number 186901-48-4, is a compound of significant interest in the fields of chemistry and pharmacology. This compound has garnered attention due to its unique properties and potential applications in various scientific domains. Recent advancements in research have shed light on its structural characteristics, biological activities, and therapeutic potentials, making it a subject of extensive study.

The chemical structure of Cortistatin-14 is characterized by a complex arrangement of atoms, which contributes to its distinctive properties. Researchers have employed advanced spectroscopic techniques to elucidate its molecular architecture, revealing insights into its functional groups and spatial arrangement. These findings have been instrumental in understanding how Cortistatin-14 interacts with biological systems, paving the way for its application in drug development.

One of the most promising aspects of Cortistatin-14 is its potential as a therapeutic agent. Recent studies have demonstrated its ability to modulate key cellular pathways involved in disease progression. For instance, investigations into its anti-inflammatory and antioxidant properties have highlighted its potential in treating conditions such as neurodegenerative diseases and cardiovascular disorders. Furthermore, preclinical trials have shown that Cortistatin-14 exhibits selective cytotoxicity against cancer cells, making it a candidate for anticancer therapies.

The synthesis of Cortistatin-14 has also been a focal point of research. Scientists have developed innovative synthetic routes that enhance the efficiency and scalability of production processes. These advancements are crucial for transitioning from laboratory-scale synthesis to industrial manufacturing, ensuring that Cortistatin-14 can be made available for broader applications.

In addition to its therapeutic potential, Cortistatin-14 has shown promise in diagnostic applications. Researchers have explored its use as a contrast agent in imaging techniques, leveraging its unique chemical properties to improve diagnostic accuracy. This dual role as both a therapeutic and diagnostic agent underscores the versatility of Cortistatin-14 in the medical field.

Recent breakthroughs in computational chemistry have further enhanced our understanding of Cortistatin-14 strong>. Advanced modeling techniques have enabled researchers to predict its interactions with biological targets with unprecedented accuracy. These computational tools are invaluable for optimizing drug design and predicting potential side effects, thereby accelerating the development process.

The environmental impact of Cortistatin-14 strong> is another area of growing interest. As concerns about chemical pollution increase, researchers are investigating the biodegradation pathways of this compound to ensure its safe use and disposal. Preliminary findings suggest that under certain conditions, Cortistatin-14 strong> can undergo efficient biodegradation, reducing its environmental footprint.

In conclusion, Cortistatin-14 strong>, with its CAS number 186901-48-4, represents a cutting-edge compound with vast potential across multiple scientific disciplines. Its unique chemical properties, coupled with recent research advancements, position it as a key player in future medical and technological innovations.

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