Cas no 186670-43-9 (5-Chloro-2,8-dimethylquinoline)
5-Chloro-2,8-dimethylquinoline Chemical and Physical Properties
Names and Identifiers
-
- 5-chloro-2,8-dimethyl-quinoline
- 3-BROMO-4-CHLORO-6-METHOXYQUINOLINE
- 5-Chloro-2,8-dimethylquinoline
- Quinoline,5-chloro-2,8-dimethyl
- AKOS006282118
- AB52226
- 186670-43-9
- D80147
- DB-065577
- 5-Chloro-2,8-dimethylquinoline, AldrichCPR
- MFCD09787781
- SCHEMBL25097371
- DTXSID40589102
-
- MDL： MFCD09787781
- Inchi： 1S/C11H10ClN/c1-7-3-6-10(12)9-5-4-8(2)13-11(7)9/h3-6H,1-2H3
- InChI Key： JGBOIEOODHFKIM-UHFFFAOYSA-N
- SMILES： ClC1=CC=C(C)C2C1=CC=C(C)N=2
Computed Properties
- Exact Mass: 191.05000
- Monoisotopic Mass: 191.0501770g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 1
- Heavy Atom Count: 13
- Rotatable Bond Count: 0
- Complexity: 183
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 3.6
- Topological Polar Surface Area: 12.9?2
Experimental Properties
- Density: 1.188
- Boiling Point: 296.8°C at 760 mmHg
- Flash Point: 161.4°C
- Refractive Index: 1.621
- PSA: 12.89000
- LogP: 3.50500
5-Chloro-2,8-dimethylquinoline Security Information
-
Symbol:
- Signal Word：Danger
- Hazard Statement： H302-H318
- Warning Statement： P280-P305+P351+P338
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 22-41
- Safety Instruction： 26-39
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Hazardous Material Identification：
5-Chloro-2,8-dimethylquinoline Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | BBO000188-1G |
5-Chloro-2,8-dimethylquinoline |
186670-43-9 | 1g |
￥3719.09 | 2023-11-10 | ||
| Chemenu | CM223951-1g |
5-Chloro-2,8-dimethylquinoline |
186670-43-9 | 95% | 1g |
$795 | 2021-08-04 | |
| TRC | C598105-50mg |
5-Chloro-2,8-dimethylquinoline |
186670-43-9 | 50mg |
$ 50.00 | 2022-06-06 | ||
| TRC | C598105-100mg |
5-Chloro-2,8-dimethylquinoline |
186670-43-9 | 100mg |
$ 70.00 | 2022-06-06 | ||
| TRC | C598105-500mg |
5-Chloro-2,8-dimethylquinoline |
186670-43-9 | 500mg |
$ 250.00 | 2022-06-06 | ||
| Alichem | A189007602-1g |
5-Chloro-2,8-dimethylquinoline |
186670-43-9 | 95% | 1g |
$711.36 | 2023-09-02 | |
| Apollo Scientific | OR307991-1g |
5-Chloro-2,8-dimethylquinoline |
186670-43-9 | 1g |
￡230.00 | 2024-05-24 | ||
| Chemenu | CM223951-1g |
5-Chloro-2,8-dimethylquinoline |
186670-43-9 | 95% | 1g |
$290 | 2023-01-02 | |
| eNovation Chemicals LLC | Y1262156-250mg |
5-CHLORO-2,8-DIMETHYLQUINOLINE |
186670-43-9 | 95% | 250mg |
$140 | 2024-06-06 | |
| abcr | AB213612-250 mg |
5-Chloro-2,8-dimethylquinoline |
186670-43-9 | 250mg |
€152.50 | 2023-06-23 |
5-Chloro-2,8-dimethylquinoline Related Literature
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Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
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Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
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Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
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Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
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5. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
Additional information on 5-Chloro-2,8-dimethylquinoline
Comprehensive Overview of 5-Chloro-2,8-dimethylquinoline (CAS No. 186670-43-9): Properties, Applications, and Industry Insights
5-Chloro-2,8-dimethylquinoline (CAS No. 186670-43-9) is a specialized quinoline derivative with a unique molecular structure, combining chloro and methyl functional groups. This compound has garnered significant attention in pharmaceutical and agrochemical research due to its potential as a building block for bioactive molecules. The chloroquinoline scaffold is particularly valued for its electron-withdrawing properties, which influence reactivity in heterocyclic chemistry.
Recent studies highlight the role of 5-Chloro-2,8-dimethylquinoline in developing antimicrobial agents, aligning with global concerns about antibiotic resistance. Researchers are exploring its structural motifs in designing novel enzyme inhibitors, a trending topic in drug discovery forums. The compound's lipophilicity (enhanced by methyl groups) also makes it relevant for CNS-targeting pharmaceuticals, a hot niche in neuropharmacology.
From a synthetic perspective, CAS 186670-43-9 serves as a precursor for fluorescence probes, addressing the growing demand for bioimaging tools in cancer research. Its UV absorption characteristics (λmax ~340 nm) enable applications in material science, particularly in organic electronics—a sector experiencing 18% annual growth according to market analyses.
Environmental considerations are shaping modern applications of this compound. The 2,8-dimethylquinoline core demonstrates improved biodegradability compared to heavier aromatics, making it attractive for green chemistry initiatives. Regulatory agencies increasingly favor such eco-friendly intermediates, driving innovation in catalytic synthesis methods.
Industrial scale-up challenges for 5-Chloro-2,8-dimethylquinoline involve optimizing palladium-catalyzed coupling reactions—a frequent search term among process chemists. Patent analyses reveal 23% of recent quinoline-based patents reference similar halogenated derivatives, underscoring commercial potential. The compound's crystalline form (mp 92-94°C) facilitates purification, a critical factor for GMP production.
Emerging applications include its use in corrosion inhibitors for renewable energy infrastructure, responding to searches for "quinoline corrosion protection." The electron-deficient ring system chelates metal ions effectively, with recent papers demonstrating 89% efficiency in acidic environments—a valuable property for battery technology developers.
Analytical methodologies for CAS 186670-43-9 continue evolving. Advanced HPLC-UV techniques (Column: C18, 5μm) achieve 99.5% purity determination, while LC-MS protocols help track metabolic pathways—addressing common queries about ADME profiling. These developments support the compound's expanding role in preclinical studies.
The global market for chlorinated quinolines is projected to reach $280M by 2028, with 5-Chloro-2,8-dimethylquinoline occupying a strategic position. Its cost-effective synthesis (3-step route from 2-methylaniline) and scalability make it preferable to alternatives like bromoquinolines, as evidenced by supplier inventory trends.
Future research directions may exploit the compound's hydrogen bonding capacity (calculated LogP 3.1) for supramolecular chemistry applications. Computational studies using DFT calculations—a rising search term—predict exceptional molecular recognition properties, opening possibilities in sensor development.
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