• 1. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 2. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 3. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 4. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 5. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzimidazoles Benzimidazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzimidazoles

Comprehensive Overview of 4-Fluoro-2-methyl-1H-1,3-benzodiazole (CAS No. 18645-89-1): Properties, Applications, and Industry Insights

4-Fluoro-2-methyl-1H-1,3-benzodiazole (CAS No. 18645-89-1) is a fluorinated heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural properties. The presence of both a fluoro substituent and a methyl group on the benzodiazole ring enhances its reactivity and bioavailability, making it a valuable intermediate in synthetic chemistry. Researchers and industry professionals frequently search for terms like "4-Fluoro-2-methyl-1H-1,3-benzodiazole synthesis", "CAS 18645-89-1 applications", and "benzodiazole derivatives in drug discovery", reflecting the compound's growing relevance.

The molecular structure of 4-Fluoro-2-methyl-1H-1,3-benzodiazole features a fused benzene and diazole ring system, which contributes to its stability and versatility. This scaffold is particularly attractive for designing small-molecule inhibitors and fluorescent probes, aligning with current trends in precision medicine and diagnostic imaging. Recent studies highlight its potential in modulating enzyme activity and protein-protein interactions, addressing common search queries such as "how does fluorination affect benzodiazole reactivity?" and "role of benzodiazoles in cancer therapy".

From an industrial perspective, CAS 18645-89-1 is often utilized in the development of high-performance materials and specialty chemicals. Its electron-withdrawing fluoro group improves thermal stability, making it suitable for applications in organic electronics and catalysis. Manufacturers increasingly seek information on "scalable synthesis of fluorinated benzodiazoles" and "green chemistry approaches for 18645-89-1", emphasizing the demand for sustainable production methods.

Analytical characterization of 4-Fluoro-2-methyl-1H-1,3-benzodiazole typically involves advanced techniques such as NMR spectroscopy, HPLC-MS, and X-ray crystallography. These methods confirm the compound's purity and structural integrity, critical for regulatory compliance in pharmaceutical formulations. Popular technical questions include "NMR peaks for 4-Fluoro-2-methyl-1H-1,3-benzodiazole" and "HPLC separation conditions for CAS 18645-89-1", underscoring the need for detailed analytical protocols.

Emerging applications of this compound extend to bioconjugation and proteomics research, where its benzodiazole core serves as a linker for biomolecule labeling. This aligns with the rising interest in "click chemistry compatible fluorophores" and "site-specific protein modification"—topics frequently explored in academic forums and patent literature. The compound's adaptability to photoaffinity labeling further expands its utility in target identification studies.

In summary, 4-Fluoro-2-methyl-1H-1,3-benzodiazole (CAS No. 18645-89-1) represents a multifaceted building block with broad implications across life sciences and material engineering. Its synergy with contemporary research themes—such as fragment-based drug design and functionalized heterocycles—positions it as a compound of enduring scientific and commercial interest.

• 118469-15-1(5-Fluoro-2-methyl-1H-benzodimidazole)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)