• 1. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 2. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 3. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 4. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 5. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles

Comprehensive Overview of 6-Bromo-1-(tert-butyldimethylsilyl)indole (CAS No. 184637-11-4)

6-Bromo-1-(tert-butyldimethylsilyl)indole (CAS No. 184637-11-4) is a highly versatile heterocyclic compound widely utilized in pharmaceutical research, organic synthesis, and material science. This silyl-protected indole derivative has garnered significant attention due to its unique chemical properties, making it a valuable intermediate in the development of bioactive molecules and advanced materials. Researchers and industry professionals frequently search for terms like "6-Bromo-1-TBS indole synthesis," "CAS 184637-11-4 applications," and "TBS-protected indole derivatives," reflecting its growing relevance in modern chemistry.

The compound's structure features a bromine substituent at the 6-position of the indole ring, coupled with a tert-butyldimethylsilyl (TBS) protecting group at the 1-position. This combination enhances its stability and reactivity, enabling precise functionalization in multi-step synthetic routes. Recent trends in green chemistry and sustainable synthesis have spurred interest in optimizing its preparation methods, with queries such as "eco-friendly synthesis of 6-Bromo-1-TBS indole" gaining traction. Its role in cross-coupling reactions, particularly in palladium-catalyzed transformations, further underscores its importance in constructing complex molecular architectures.

In pharmaceutical applications, 6-Bromo-1-(tert-butyldimethylsilyl)indole serves as a key precursor for drug discovery projects targeting central nervous system (CNS) disorders and anticancer agents. The bromoindole scaffold is a privileged structure in medicinal chemistry, often explored for its kinase inhibition and receptor modulation potential. Online searches frequently include phrases like "6-Bromo-1-TBS indole in drug development" and "CAS 184637-11-4 biological activity," highlighting its interdisciplinary appeal. Additionally, its compatibility with high-throughput screening platforms aligns with the demand for fragment-based drug design strategies.

From a commercial perspective, the compound's availability and purity are critical for reproducibility in research. Suppliers often emphasize HPLC-grade 6-Bromo-1-(tert-butyldimethylsilyl)indole to meet stringent quality standards, addressing common search queries like "buy 6-Bromo-1-TBS indole high purity." Analytical techniques such as NMR spectroscopy and mass spectrometry are routinely employed to verify its structural integrity, ensuring reliable performance in sensitive applications. The compound's storage conditions (e.g., inert atmosphere, low temperature) are also frequently discussed topics among end-users.

Emerging applications in material science further expand the utility of CAS No. 184637-11-4. Its incorporation into organic semiconductors and luminescent materials has been explored, driven by the indole core's electron-rich nature. Searches related to "6-Bromo-1-TBS indole in OLEDs" or "conductive polymers from bromoindoles" reflect this niche yet growing interest. The compound's adaptability to click chemistry protocols also positions it as a building block for functionalized surfaces and nanostructured materials.

In summary, 6-Bromo-1-(tert-butyldimethylsilyl)indole (CAS No. 184637-11-4) represents a cornerstone in contemporary chemical research. Its multifaceted roles—from enabling precision synthesis to advancing therapeutic innovation—resonate with diverse scientific communities. By addressing trending search terms like "6-Bromo-1-TBS indole safety data" and "scalable production methods," this overview bridges technical depth with practical insights, catering to both novice and expert audiences in the field.

• 148249-36-9(3-Bromo-1-(triisopropylsilyl)indole)
• 412048-45-4(4-Chloro-N-(tert-butyldimethylsilyl)indole)
• 412048-44-3(4-Bromo-1-(triisopropylsilyl)-1H-indole)
• 331432-91-8(1H-Indole,5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-)
• 123191-00-4(1H-Indole,1-[tris(1-methylethyl)silyl]-)
• 128564-66-9(5-bromo-1-[tris(propan-2-yl)silyl]-1H-indole)
• 918148-84-2(2-Bromo-1-[tri(propan-2-yl)silyl]-1H-indole)
• 193694-04-1(4-Bromo-1-(tert-butyldimethylsilyl)indole)
• 153942-69-9(1H-Indole, 3-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-)
• 184636-93-9(1H-Indole, 3,6-dibromo-1-[(1,1-dimethylethyl)dimethylsilyl]-)