Cas no 18437-78-0 (Tris(4-fluorophenyl)phosphine)

Tris(4-fluorophenyl)phosphine is an organophosphorus compound featuring three 4-fluorophenyl groups bonded to a central phosphorus atom. Its electron-withdrawing fluorine substituents enhance the phosphine's stability and influence its reactivity, making it a valuable ligand in transition metal catalysis. The compound is particularly useful in cross-coupling reactions, such as Suzuki-Miyaura and Heck couplings, where it facilitates efficient bond formation under mild conditions. Its air-stable nature and compatibility with various solvents further contribute to its utility in synthetic organic chemistry. Additionally, the fluorine atoms can be leveraged for further functionalization, broadening its applications in pharmaceutical and materials science research.

Tris(4-fluorophenyl)phosphine structure

Product Name:Tris(4-fluorophenyl)phosphine

CAS No:18437-78-0

MF:C₁₈H₁₂F₃P

MW:316.256855964661

MDL:MFCD00013553

CID:87954

PubChem ID:160871182

Update Time:2025-11-02

Tris(4-fluorophenyl)phosphine Chemical and Physical Properties

Names and Identifiers

- Tris(4-fluorophenyl)phosphine
- Phosphine, tris(p-fluorophenyl)-
- TRIS(P-FLUOROPHENYL)PHOSPHINE
- TRI(4-FLUOROPHENYL)PHOSPHINE
- tris(4-fluorophenyl)phosphane
- Tri-(p-fluorophenyl)phosphine
- Tris(4-fluorophenyl)
- Tris(4-Flurophenyl)Phosphine
- Tris(4-fluorophenyl)phosphine98%
- Tris(4-fluorophenyl)phosphine 98%
- Tris(p-fluorophenyl)phosphine,99%
- 18437-78-0
- FT-0637697
- tri-(4-Fluorophenyl)phosphine
- EN300-6746815
- A812866
- SCHEMBL196718
- F17176
- NSC-158458
- J-011818
- tris (p-fluorophenyl)phosphine
- tris-(4-fluoro-phenyl)-phosphane
- Tris(4-fluorophenyl)phosphine, 98%
- MFCD00013553
- HY-W008707
- Phosphine, tris(4-fluorophenyl)-
- AKOS004909006
- DTXSID80171565
- CS-W009423
- AS-59713
- NSC 158458
- C18H12F3P
- p(4-fc6h4)3
- BCP21966
- SY048540
- T2900
- NSC158458
- DB-044530
- DTXCID7094056
- 627-663-4
- MDL： MFCD00013553
- Inchi： 1S/C18H12F3P/c19-13-1-7-16(8-2-13)22(17-9-3-14(20)4-10-17)18-11-5-15(21)6-12-18/h1-12H
- InChI Key： GEPJPYNDFSOARB-UHFFFAOYSA-N
- SMILES： P(C1C=CC(=CC=1)F)(C1C=CC(=CC=1)F)C1C=CC(=CC=1)F
- BRN： 919838

Computed Properties

Exact Mass: 316.06300
Monoisotopic Mass: 316.063
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 0
Heavy Atom Count: 22
Rotatable Bond Count: 3
Complexity: 275
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: 4.9
Topological Polar Surface Area: 0A^2

Experimental Properties

Color/Form: Uncertain
Density: 1.1320
Melting Point: 79.0 to 83.0 deg-C
Boiling Point: 160°C/0.1mmHg(lit.)
Flash Point: 166.4±26.5 °C
Refractive Index: 1.558
Water Partition Coefficient: Insoluble in water.
PSA: 13.59000
LogP: 3.86210
Sensitiveness: Air Sensitive
Solubility: Uncertain
Vapor Pressure: No data available

Tris(4-fluorophenyl)phosphine Security Information

Symbol:
Prompt：warning
Signal Word：Warning
Hazard Statement： H315,H319,H335
Warning Statement： P261,P305+P351+P338
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Hazard Category Code： 36/37/38
Safety Instruction： S26-S36
Hazardous Material Identification：
Safety Term：S26-36
Risk Phrases：R36/37/38
HazardClass：IRRITANT
Storage Condition：Argon filled storage

Tris(4-fluorophenyl)phosphine Customs Data

HS CODE：2903999090
Customs Data：

China Customs Code:
2903999090

Overview:

2903999090 Other aromatic halogenated derivatives. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

Declaration elements:

Product Name, component content, use to

Summary:

2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Tris(4-fluorophenyl)phosphine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Fluorochem	007752-1g	Tris(4-fluorophenyl)phosphine	18437-78-0	98%	1g	￡10.00	2022-03-01
Fluorochem	007752-5g	Tris(4-fluorophenyl)phosphine	18437-78-0	98%	5g	￡24.00	2022-03-01
Fluorochem	007752-10g	Tris(4-fluorophenyl)phosphine	18437-78-0	98%	10g	￡40.00	2022-03-01
Fluorochem	007752-25g	Tris(4-fluorophenyl)phosphine	18437-78-0	98%	25g	￡80.00	2022-03-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	T115596-25g	Tris(4-fluorophenyl)phosphine	18437-78-0	98%	25g	￥308.90	2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	T115596-1g	Tris(4-fluorophenyl)phosphine	18437-78-0	98%	1g	￥29.90	2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	T115596-100g	Tris(4-fluorophenyl)phosphine	18437-78-0	98%	100g	￥1029.90	2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	T115596-5g	Tris(4-fluorophenyl)phosphine	18437-78-0	98%	5g	￥72.90	2023-09-01
Chemenu	CM250657-100g	Tris(4-fluorophenyl)phosphine	18437-78-0	97%	100g	$281	2021-08-04
Alichem	A019118965-100g	Tris(4-fluorophenyl)phosphine	18437-78-0	97%	100g	$297.00	2023-09-02

Tris(4-fluorophenyl)phosphine Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:18437-78-0)三（4-氟苯基）膦

Order Number:LE1730147

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:35

Price ($):discuss personally

Email:[email protected]

Tris(4-fluorophenyl)phosphine Related Literature

1. A bimetallic Ag15Cu12(S-c-C6H11)18(CH3COO)3 nanocluster featuring an irregular Ag12 kernel

Zhenzhen Lin,Ting Zhang,Cao Fang,Shan Jin,Chang Xu,Daqiao Hu,Manzhou Zhu Dalton Trans. 2023 52 971
2. Remarkable effect of tris(4-fluorophenyl)phosphine oxide on the stabilization of chiral lanthanum complex catalysts. A new and practical protocol for the highly enantioselective epoxidation of conjugated enones

Rie Kino,Kazuhiro Daikai,Toshio Kawanami,Hiroshi Furuno,Junji Inanaga Org. Biomol. Chem. 2004 2 1822
3. Enantioselective intramolecular C–H amination of aliphatic azides by dual ruthenium and phosphine catalysis

Jie Qin,Zijun Zhou,Tianjiao Cui,Marcel Hemming,Eric Meggers Chem. Sci. 2019 10 3202
4. Effect of methyl and halogen substituents on the transmembrane movement of lipophilic ions

Tatyana I. Rokitskaya,Victor B. Luzhkov,Galina A. Korshunova,Vadim N. Tashlitsky,Yuri N. Antonenko Phys. Chem. Chem. Phys. 2019 21 23355
5. Cocrystallization-driven stabilization of metastable nanoclusters: a case study of Pd1Au9

Honglei Shen,Xiao Wei,Chao Xu,Shan Jin,Shuxin Wang,Xi Kang,Manzhou Zhu Nanoscale 2021 13 7694

Related Categories

Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylphosphines and derivatives

Additional information on Tris(4-fluorophenyl)phosphine

Comprehensive Guide to Tris(4-fluorophenyl)phosphine (CAS No. 18437-78-0): Properties, Applications, and Market Insights

Tris(4-fluorophenyl)phosphine (CAS No. 18437-78-0) is a specialized organophosphorus compound widely used in catalysis, material science, and pharmaceutical research. With the growing demand for fluorinated compounds in high-tech industries, this chemical has gained significant attention due to its unique electronic properties and stability. Below, we explore its chemical structure, key applications, and emerging trends in scientific research.

The molecular formula of Tris(4-fluorophenyl)phosphine is C₁₈H₁₂F₃P, featuring three 4-fluorophenyl groups bonded to a central phosphorus atom. This structure enhances its electron-withdrawing capabilities, making it valuable in cross-coupling reactions such as the Suzuki-Miyaura and Heck reactions. Researchers frequently search for "fluorinated phosphine ligands" or "18437-78-0 applications," reflecting its importance in modern synthetic chemistry.

One of the most notable uses of Tris(4-fluorophenyl)phosphine is in OLED (Organic Light-Emitting Diode) technology. As the demand for flexible displays and energy-efficient lighting grows, this compound serves as a critical electron-transport material. Its thermal stability and compatibility with thin-film deposition processes make it ideal for next-generation optoelectronic devices.

In pharmaceutical synthesis, Tris(4-fluorophenyl)phosphine acts as a ligand for palladium catalysts, enabling efficient C-C bond formation. This is particularly relevant for drug discovery, where "phosphine ligands in medicinal chemistry" is a trending search query. The compound’s fluorine substituents also improve solubility in organic solvents, simplifying purification steps.

Market trends indicate rising interest in sustainable catalysis, with Tris(4-fluorophenyl)phosphine being explored for green chemistry applications. Recent studies highlight its role in recyclable catalytic systems, aligning with global efforts to reduce chemical waste. Keywords like "eco-friendly phosphine ligands" and "18437-78-0 price" are frequently searched, reflecting commercial and environmental concerns.

Handling and storage recommendations for Tris(4-fluorophenyl)phosphine emphasize protection from moisture and oxygen to prevent degradation. While not classified as hazardous, proper glovebox techniques are advised for sensitive applications. Industry professionals often inquire about "stable fluorinated phosphines" or "CAS 18437-78-0 suppliers," underscoring its niche but vital role in R&D.

In summary, Tris(4-fluorophenyl)phosphine (CAS No. 18437-78-0) bridges multiple cutting-edge fields, from organic electronics to drug development. Its versatility and compatibility with green chemistry principles position it as a compound of enduring relevance. For researchers and suppliers, staying updated on its synthetic protocols and market availability is essential to leverage its full potential.

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