Cas no 183622-36-8 (1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine)
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine is a versatile intermediate in organic synthesis, particularly valuable for pharmaceutical and biochemical research. The compound features a Boc-protected piperazine moiety, which enhances stability and facilitates selective deprotection under mild acidic conditions. The presence of both a carboxylic acid and a nitro group on the phenyl ring offers multiple reactive sites for further functionalization, making it suitable for coupling reactions, amide formation, or reduction to amino derivatives. Its well-defined structure and high purity ensure reproducibility in synthetic applications. This compound is particularly useful in the development of bioactive molecules, such as kinase inhibitors or receptor modulators, due to its balanced reactivity and compatibility with diverse reaction conditions.
183622-36-8 structure
Product Name:1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine
CAS No:183622-36-8
MF:C16H21N3O6
MW:351.354444265366
MDL:MFCD09878788
CID:114157
PubChem ID:11792233
Update Time:2025-07-02
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine Chemical and Physical Properties
Names and Identifiers
-
- 5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-nitrobenzoic acid
- 1-N-BOC-4-(3-CARBOXY-4-NITROPHENYL)PIPERAZINE
- 1-Piperazinecarboxylicacid, 4-(3-carboxy-4-nitrophenyl)-, 1-(1,1-dimethylethyl) ester
- 5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-2-nitrobenzoic acid
- 4-(3-CARBOXY-4-NITRO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- 5-(4-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-1-Piperazinyl)-2-Nitrobenzoic Acid
- 5-[(4-tert-butoxycarbonyl)-piperazin-1-yl]-2-nitrobenzoic acid
- AB54004
- DTXSID90472939
- MD-0048
- 1-Piperazinecarboxylic acid, 4-(3-carboxy-4-nitrophenyl)-, 1-(1,1-dimethylethyl) ester
- 183622-36-8
- 5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-nitrobenzoicacid
- 5-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-2-nitrobenzoic acid
- CS-0171796
- AKOS022172429
- SCHEMBL5863471
- SY239656
- MFCD09878788
- 5-(4-Boc-1-piperazinyl)-2-nitrobenzoic Acid
- 5-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]-2-NITROBENZOIC ACID
- 1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine
-
- MDL： MFCD09878788
- Inchi： 1S/C16H21N3O6/c1-16(2,3)25-15(22)18-8-6-17(7-9-18)11-4-5-13(19(23)24)12(10-11)14(20)21/h4-5,10H,6-9H2,1-3H3,(H,20,21)
- InChI Key： UURLRAAZXIBLIQ-UHFFFAOYSA-N
- SMILES： O(C(C)(C)C)C(N1CCN(C2C=CC(=C(C(=O)O)C=2)[N+](=O)[O-])CC1)=O
Computed Properties
- Exact Mass: 351.14300
- Monoisotopic Mass: 351.14303540g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 25
- Rotatable Bond Count: 6
- Complexity: 519
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.1
- Topological Polar Surface Area: 116?2
Experimental Properties
- Color/Form: Pale-yellow to Yellow-brown Liquid
- Density: 1.329
- Boiling Point: 555.6°Cat760mmHg
- Flash Point: 289.8°C
- Refractive Index: 1.583
- PSA: 115.90000
- LogP: 2.87620
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine Security Information
- Signal Word：Warning
- Hazard Statement： H302;H315;H319;H335
- Warning Statement： P261;P280;P301+P312;P302+P352;P305+P351+P338
- Storage Condition：Room temperature
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine Customs Data
- HS CODE：2933599090
- Customs Data：
China Customs Code:
2933599090Overview:
2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| AstaTech | 56440-1/G |
1-N-BOC-4-(3-CARBOXY-4-NITROPHENYL)PIPERAZINE |
183622-36-8 | 97% | 1g |
$45 | 2023-09-17 | |
| AstaTech | 56440-5/G |
1-N-BOC-4-(3-CARBOXY-4-NITROPHENYL)PIPERAZINE |
183622-36-8 | 97% | 5g |
$159 | 2023-09-17 | |
| AstaTech | 56440-10/G |
1-N-BOC-4-(3-CARBOXY-4-NITROPHENYL)PIPERAZINE |
183622-36-8 | 97% | 10/G |
$902 | 2022-06-01 | |
| Alichem | A139004599-5g |
1-N-Boc-4-(3-carboxy-4-nitrophenyl)piperazine |
183622-36-8 | 95% | 5g |
$292.05 | 2023-09-02 | |
| Fluorochem | 048501-1g |
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine |
183622-36-8 | 95% | 1g |
￡152.00 | 2022-03-01 | |
| Fluorochem | 048501-5g |
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine |
183622-36-8 | 95% | 5g |
￡657.00 | 2022-03-01 | |
| Fluorochem | 048501-10g |
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine |
183622-36-8 | 95% | 10g |
￡1015.00 | 2022-03-01 | |
| TRC | B701118-50mg |
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine |
183622-36-8 | 50mg |
$ 50.00 | 2022-06-06 | ||
| TRC | B701118-100mg |
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine |
183622-36-8 | 100mg |
$ 65.00 | 2022-06-06 | ||
| TRC | B701118-500mg |
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine |
183622-36-8 | 500mg |
$ 160.00 | 2022-06-06 |
1-N-Boc-4-(3-Carboxy-4-nitrophenyl)piperazine Related Literature
-
Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
-
Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
-
Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
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