• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408
• 3. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 4. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 5. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551

Professional Introduction to Tert-butyl 4-(hydroxymethyl)-3-methylpiperidine-1-carboxylate (CAS No. 1824290-29-0)

Tert-butyl 4-(hydroxymethyl)-3-methylpiperidine-1-carboxylate, with the CAS number 1824290-29-0, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and drug development. This compound belongs to the piperidine class of heterocyclic amines, characterized by its unique structural and chemical properties. The presence of both hydroxymethyl and tert-butyl substituents on the piperidine ring imparts distinct reactivity and functionality, making it a valuable intermediate in the synthesis of various bioactive molecules.

The tert-butyl group, a tertiary alkyl group, enhances the compound's stability and lipophilicity, which are crucial factors in drug design for improving membrane permeability and metabolic stability. On the other hand, the hydroxymethyl group introduces hydrophilic characteristics, facilitating interactions with biological targets. This balance of hydrophobic and hydrophilic properties makes Tert-butyl 4-(hydroxymethyl)-3-methylpiperidine-1-carboxylate a versatile building block in medicinal chemistry.

In recent years, there has been growing interest in piperidine derivatives due to their broad spectrum of biological activities. Piperidine-based compounds have been reported to exhibit pharmacological effects ranging from antiviral and anti-inflammatory to anticancer properties. The specific arrangement of functional groups on the piperidine ring can significantly influence the compound's binding affinity and selectivity towards target enzymes or receptors. For instance, modifications at the 4-position, such as the introduction of a hydroxymethyl group, have been shown to enhance binding interactions with certain protein targets.

Recent studies have highlighted the potential of Tert-butyl 4-(hydroxymethyl)-3-methylpiperidine-1-carboxylate as a key intermediate in the synthesis of novel therapeutic agents. Researchers have leveraged its structural features to develop inhibitors targeting various disease pathways. For example, derivatives of this compound have been explored as potential kinase inhibitors, which are critical in treating cancers and inflammatory diseases. The tert-butyl group's steric bulk helps in optimizing binding interactions, while the hydroxymethyl group can participate in hydrogen bonding or other non-covalent interactions with biological targets.

The pharmaceutical industry has been particularly interested in developing small molecule inhibitors that can modulate enzyme activity with high selectivity. Piperidine derivatives, including Tert-butyl 4-(hydroxymethyl)-3-methylpiperidine-1-carboxylate, offer a promising scaffold for such inhibitors due to their ability to mimic natural substrates or allosteric sites on enzymes. The synthesis of these compounds often involves multi-step organic reactions that require precise control over reaction conditions to achieve high yields and purity.

In addition to its role in drug development, Tert-butyl 4-(hydroxymethyl)-3-methylpiperidine-1-carboxylate has found applications in materials science and agrochemicals. Its unique chemical properties make it suitable for synthesizing complex molecules that exhibit specific functionalities. For instance, researchers have utilized this compound to develop novel polymers with enhanced thermal stability or biodegradability. These advancements underscore the compound's versatility beyond traditional pharmaceutical applications.

The future prospects of Tert-butyl 4-(hydroxymethyl)-3-methylpiperidine-1-carboxylate are promising, with ongoing research exploring new synthetic pathways and applications. Advances in computational chemistry and high-throughput screening techniques are expected to accelerate the discovery of novel derivatives with improved pharmacological profiles. Collaborative efforts between academia and industry will be crucial in translating these findings into tangible therapeutic solutions for various diseases.

In conclusion, Tert-butyl 4-(hydroxymethyl)-3-methylpiperidine-1-carboxylate (CAS No. 1824290-29-0) is a multifaceted compound with significant potential in pharmaceutical research and industrial applications. Its unique structural features and reactivity make it an invaluable tool for synthesizing bioactive molecules targeting diverse disease pathways. As research continues to uncover new applications for this compound, its importance in advancing drug development and material science is likely to grow even further.

• 374795-35-4(tert-Butyl 3-(2-hydroxyethyl)-3-(hydroxymethyl)piperidine-1-carboxylate)
• 1706455-11-9(tert-butyl 1-(hydroxymethyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate)
• 2679935-07-8(tert-butyl (1R,5S,7s)-7-(hydroxymethyl)-3-azabicyclo3.3.1nonane-3-carboxylate)
• 140695-84-7(tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate)
• 140695-85-8(tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate)
• 1956437-11-8(tert-butyl (3S)-3-(hydroxymethyl)-3-methyl-piperidine-1-carboxylate)
• 116574-71-1(Tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate)
• 2228910-64-1(Tert-butyl 3-(4-hydroxy-3,3-dimethylbutyl)piperidine-1-carboxylate)
• 2228612-34-6(tert-butyl 4-1-(hydroxymethyl)cyclopropyl-3-methylpiperidine-1-carboxylate)
• 637301-16-7(1-Boc-3-azabicyclo[3.2.1]octane-8-Methanol)