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Comprehensive Guide to 4,4-Difluoro-5-methylazepane hydrochloride (CAS No. 1823931-22-1): Properties, Applications, and Market Insights

4,4-Difluoro-5-methylazepane hydrochloride (CAS No. 1823931-22-1) is a fluorinated organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural properties. This compound belongs to the class of azepane derivatives, which are known for their versatility in drug discovery and material science. The presence of fluorine atoms in its structure enhances its metabolic stability and bioavailability, making it a valuable intermediate in the synthesis of bioactive molecules.

The chemical formula of 4,4-Difluoro-5-methylazepane hydrochloride is C₇H₁₄ClF₂N, and its molecular weight is approximately 193.64 g/mol. The compound features a seven-membered azepane ring substituted with two fluorine atoms at the 4-position and a methyl group at the 5-position. The hydrochloride salt form improves its solubility in aqueous solutions, facilitating its use in various laboratory and industrial applications.

One of the most frequently asked questions about 4,4-Difluoro-5-methylazepane hydrochloride is its role in medicinal chemistry. Researchers are particularly interested in its potential as a building block for central nervous system (CNS) drugs, given the azepane scaffold's prevalence in neuroactive compounds. The fluorine substituents can influence the compound's binding affinity to biological targets, a topic that aligns with current trends in fluorinated drug design.

In addition to pharmaceutical applications, 4,4-Difluoro-5-methylazepane hydrochloride is also explored in material science. Its fluorinated structure contributes to the development of specialty polymers and coatings with enhanced thermal and chemical resistance. This aligns with the growing demand for high-performance materials in industries such as aerospace and electronics.

The synthesis of 4,4-Difluoro-5-methylazepane hydrochloride typically involves multi-step organic reactions, including fluorination and ring-closure strategies. Researchers often search for efficient synthetic routes to this compound, as optimizing its production is critical for cost-effective scaling. Recent advancements in flow chemistry and catalysis have provided new opportunities for improving its synthesis.

From a market perspective, the demand for 4,4-Difluoro-5-methylazepane hydrochloride is driven by its applications in drug discovery and material innovation. Companies specializing in custom synthesis and contract research are increasingly offering this compound to meet the needs of academic and industrial laboratories. Its pricing and availability are influenced by factors such as raw material costs and regulatory requirements.

Safety and handling of 4,4-Difluoro-5-methylazepane hydrochloride are also common concerns among users. While it is not classified as a hazardous material, proper laboratory practices, such as the use of personal protective equipment (PPE) and adequate ventilation, are recommended. Researchers often inquire about its storage conditions and stability, which are crucial for maintaining its integrity over time.

In summary, 4,4-Difluoro-5-methylazepane hydrochloride (CAS No. 1823931-22-1) is a promising compound with diverse applications in pharmaceuticals and materials science. Its fluorinated azepane structure offers unique advantages for drug design and material development, making it a subject of ongoing research. As the scientific community continues to explore its potential, this compound is likely to remain a key player in innovative chemical solutions.

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