Cas no 1823731-36-7 (2,6-Dichloro-5-methylpyrimidin-4-ol)

2,6-Dichloro-5-methylpyrimidin-4-ol is a halogenated pyrimidine derivative with significant utility in organic synthesis and pharmaceutical intermediates. Its structure, featuring reactive chloro substituents at the 2- and 6-positions and a hydroxyl group at the 4-position, enables versatile functionalization, making it valuable for constructing complex heterocyclic compounds. The methyl group at the 5-position enhances stability and influences electronic properties, facilitating selective modifications. This compound is particularly useful in nucleoside chemistry and agrochemical applications due to its ability to serve as a scaffold for further derivatization. High purity and consistent reactivity ensure reliable performance in research and industrial processes.
2,6-Dichloro-5-methylpyrimidin-4-ol structure
1823731-36-7 structure
Product Name:2,6-Dichloro-5-methylpyrimidin-4-ol
CAS No:1823731-36-7
MF:C5H4Cl2N2O
MW:179.004058837891
MDL:MFCD21603988
CID:5684012
PubChem ID:136326586
Update Time:2025-10-29

2,6-Dichloro-5-methylpyrimidin-4-ol Chemical and Physical Properties

Names and Identifiers

    • EN300-25387071
    • 1823731-36-7
    • 2,6-Dichloro-5-methylpyrimidin-4-ol
    • 4(1H)-Pyrimidinone, 2,6-dichloro-5-methyl-
    • MDL: MFCD21603988
    • Inchi: 1S/C5H4Cl2N2O/c1-2-3(6)8-5(7)9-4(2)10/h1H3,(H,8,9,10)
    • InChI Key: YMVOICQMYQEPBW-UHFFFAOYSA-N
    • SMILES: ClC1=C(C)C(NC(=N1)Cl)=O

Computed Properties

  • Exact Mass: 177.9700681g/mol
  • Monoisotopic Mass: 177.9700681g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 0
  • Complexity: 244
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.5
  • Topological Polar Surface Area: 41.5?2

Experimental Properties

  • Density: 1?+-.0.1 g/cm3(Predicted)
  • Boiling Point: 234.8±50.0 °C(Predicted)
  • pka: 4.42±0.50(Predicted)

2,6-Dichloro-5-methylpyrimidin-4-ol Pricemore >>

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2,6-Dichloro-5-methylpyrimidin-4-ol Related Literature

Additional information on 2,6-Dichloro-5-methylpyrimidin-4-ol

Introduction to CAS No. 1823731-36-7: 2,6-Dichloro-5-methylpyrimidin-4-ol

The compound with CAS No. 1823731-36-7, commonly referred to as 2,6-Dichloro-5-methylpyrimidin-4-ol, is a significant organic molecule in the field of chemistry and pharmacology. This compound belongs to the pyrimidine family, which is a heterocyclic aromatic system with two nitrogen atoms at positions 1 and 3. The long-tail keyword for this compound is "synthesis of 2,6-Dichloro-5-methylpyrimidin-4-ol", which has been extensively studied in recent years due to its potential applications in drug discovery and material science.

2,6-Dichloro-5-methylpyrimidin-4-ol is characterized by its unique structure, featuring chlorine atoms at positions 2 and 6, a methyl group at position 5, and a hydroxyl group at position 4. This arrangement imparts specific chemical properties that make it valuable in various research domains. Recent studies have highlighted its role as an intermediate in the synthesis of bioactive compounds, particularly in the development of antiviral and anticancer agents.

The synthesis of 2,6-Dichloro-5-methylpyrimidin-4-ol involves a series of intricate chemical reactions. Researchers have employed methods such as nucleophilic substitution, condensation reactions, and oxidation processes to achieve this compound efficiently. One notable approach involves the use of chlorinated precursors and selective oxidation techniques to introduce the hydroxyl group at position 4. These methods have been optimized in recent years to improve yield and purity, making them more suitable for large-scale production.

One of the most exciting developments in the study of 2,6-Dichloro-5-methylpyrimidin-4-ol is its application in drug design. Scientists have explored its ability to act as a scaffold for constructing bioactive molecules with potential therapeutic benefits. For instance, derivatives of this compound have shown promise in inhibiting viral replication mechanisms, making them candidates for antiviral therapies. Additionally, research has demonstrated its potential as an anticancer agent due to its ability to target specific cellular pathways involved in tumor growth.

In terms of chemical properties, 2,6-Dichloro-5-methylpyrimidin-4 ol exhibits high stability under standard conditions but can undergo transformations under specific reaction conditions. Its solubility in various solvents has been extensively studied, which is crucial for its application in pharmaceutical formulations. Recent studies have also focused on understanding its interaction with biological systems, particularly its pharmacokinetics and toxicity profiles.

The demand for "synthesis of 2,6-Dichloro -5-methylpyrimidin -4 -ol" has surged due to its increasing relevance in both academic and industrial settings. Researchers are continually exploring novel synthetic routes that are environmentally friendly and cost-effective. Green chemistry approaches, such as using microwave-assisted synthesis or catalytic systems with minimal environmental impact, have gained traction in recent years.

Moreover, the structural versatility of 2 ,6 -Dichloro -5 -methyl pyrim idin -4 -ol has made it a valuable tool in material science applications. Its ability to form stable complexes with metal ions has led to investigations into its potential use in catalysis and sensor development. Recent breakthroughs include the use of this compound as a ligand in metalloorganic frameworks (MOFs), which are promising materials for gas storage and separation technologies.

In conclusion , CAS No . 1823731 -36 -7: 2 ,6 -Dichlor o -5 -methyl pyrim idin -4 ol stands out as a versatile compound with diverse applications across multiple disciplines . Its synthesis , properties , and potential uses continue to be explored actively , driven by advancements in chemical research . As new findings emerge , this compound is poised to play an even more significant role in shaping future innovations in medicine , materials science , and beyond .

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